Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

[18] Hybridization of denatured RNA transferred or dotted to nitrocellulose paper

1983 • 1,112 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

Bacterial Endotoxins and Host Immune Responses

1980 • 629 citations

T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

1982 • 445 citations

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1986 • 344 citations

IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide.

1988 • 308 citations

The CBA/N Mouse Strain: An Experimental Model Illustration the Influence of the X-Chromosome on Immunity

1982 • 305 citations

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.

1988 • 285 citations

Mitogen- and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching

1988 • 277 citations

B lymphocyte differentiation induced by lipopolysaccharide. I. Generation of cells synthesizing four major immunoglobulin classes.

1975 • 250 citations

The role of IL-5 in IgA B cell differentiation.

1988 • 240 citations

Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5.

1987 • 236 citations

Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.

1986 • 220 citations

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.

1988 • 208 citations

Immunoglobulin class switching

1984 • 208 citations

Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma.

1989 • 172 citations

Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.

1982 • 157 citations

B cell stimulatory factor-1 (interleukin 4) prepares resting murine B cells to secrete IgG1 upon subsequent stimulation with bacterial lipopolysaccharide.

1987 • 154 citations

Reversibility of muscle differentiation in the absence of commitment: Analysis of a myogenic cell line temperature-sensitive for commitment

1983 • 154 citations

Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor.

1982 • 140 citations

B Lymphocyte Differentiation Induced by Lipopolysaccharide

1975 • 138 citations

Structure and expression of germ line immunoglobulin gamma 2b transcripts.

1988 • 136 citations

Rapid induction of transcription of unrearranged S gamma 1 switch regions in activated murine B cells by interleukin 4.

1989 • 134 citations

Interleukin 4 instructs uncommitted B lymphocytes to switch to IgG_l and IgE

1988 • 119 citations

Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts.

1986 • 95 citations

Directed Ig class switch recombination in activated murine B cells.

1987 • 94 citations

Clonal analysis of B cells induced to secrete IgG by T cell-derived lymphokine(s).

1984 • 87 citations

DNA sequence of the murine gamma 1 switch segment reveals novel structural elements.

1986 • 86 citations

Independent immunoglobulin class-switch events occurring in a single myeloma cell line.

1985 • 81 citations

Regulation of Ig Class Secretion by Soluble Products of Certain T‐Cell Lines

1984 • 81 citations

Interleukin 4 (IgG₁ induction factor): a multifunctional lymphokine acting also on T cells

1987 • 75 citations

Cloning of mouse immunoglobulin epsilon gene and its location within the heavy chain gene cluster.

1981 • 70 citations

Partial biochemical characterization of IgG₁‐inducing factor

1985 • 69 citations

Secretion of IgG₁ induction factor by T cell clones and hybridomas

1985 • 68 citations

Structural analysis of the murine IgG3 constant region gene.

1984 • 64 citations

Nucleotide sequence and properties of the murine γ3 immunoglobulin heavy chain gene switch region: implications for successive C_γgene switching

1982 • 60 citations

Control of Immunoglobulin Class Switch Recombination

1986 • 60 citations

Deletion of Cmu genes in mouse B lymphocytes upon stimulation with LPS.

1983 • 60 citations

Surface Ig Isotypes on Cells Responding to Lipopolysaccharide by IgM and IgG Secretion

1979 • 56 citations

Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes.

1990 • 51 citations

Influence of RU 41.740, a glycoprotein extract from Klebsiella pneumoniae, on the murine immune system. I. T-independent polyclonal B cell activation.

1984 • 44 citations

Unequal sister chromatid exchange. A mechanism affecting Ig gene arrangement and expression.

1985 • 40 citations

Sequence analysis of cloned cDNA encoding part of an immunoglobulin heavy chain

1979 • 39 citations

The immunoglobulin heavy chain switch: structural features of gamma 1 recombinant switch regions.

1987 • 29 citations

Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice: natural killer cell activity in cultured spleen leukocytes concomitant with T-cell-dependent immune interferon production

1980 • 24 citations

IgG1 Induction Factor

1987 • 7 citations