Receptor-specific induction of NF-kappaB components in primary B cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

1992 • 731 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

The precursor of NF-κB p50 has IκB-like functions

1992 • 409 citations

RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.

1992 • 375 citations

Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

1994 • 358 citations

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.

1993 • 291 citations

Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation

1994 • 275 citations

IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family

1992 • 274 citations

Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB

1992 • 250 citations

Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation.

1992 • 245 citations

The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.

1992 • 234 citations

Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation

1993 • 225 citations

The rel-associated pp40 protein prevents DNA binding of Rel and NF-kappa B: relationship with I kappa B beta and regulation by phosphorylation.

1991 • 210 citations

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.

1995 • 201 citations

Induction of the transcription factors NF-кB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor

1995 • 192 citations

Autoregulation of the NF-kappa B transactivator RelA(p65) by multiple cytoplasmic inhibitors containing ankyrinmotifs.

1994 • 187 citations

The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B.

1993 • 155 citations

Signal Transducer and Activator of Transcription-3 (STAT3) Is Constitutively Activated in Normal, Self-renewing B-1 Cells but Only Inducibly Expressed in Conventional B Lymphocytes

1997 • 146 citations

Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation.

1994 • 125 citations

Oncogenic transformation by vrel requires an amino-terminal activation domain.

1990 • 123 citations

Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen.

1994 • 120 citations

Biochemistry of B Lymphocyte Activation

1993 • 120 citations

Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.

1994 • 114 citations

B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching.

1996 • 111 citations

NF-κB p100 (Lyt-10) is a Component of H2TF1 and can Function as an IκB-Like Molecule

1993 • 106 citations

Inducible nuclear expression of NF-kappa B in primary B cells stimulated through the surface Ig receptor.

1991 • 103 citations

Differential Transcriptional Activation in Vitro by NF- κB/Rel Proteins

1995 • 101 citations

Identification and analysis of all components of a gel retardation assay by combination with immunoblotting.

1993 • 94 citations

T cell-dependent induction of NF-kappa B in B cells.

1993 • 93 citations

Both N- and C-Terminal Domains of RelB Are Required for Full Transactivation: Role of the N-Terminal Leucine Zipper-Like Motif

1993 • 87 citations

Vascular smooth muscle cells express a constitutive NF-kappa B-like activity.

1994 • 76 citations

Receptor-specific induction of individual AP-1 components in B lymphocytes.

1995 • 72 citations

Role of CD40-CD40-ligand interaction in Ig-isotype switching

1993 • 69 citations

NF-kappa B precursor p100 inhibits nuclear translocation and DNA binding of NF-kappa B/rel-factors.

1993 • 68 citations

Antigen-receptor engagement in B cells induces nuclear expression of STAT5 and STAT6 proteins that bind and transactivate an IFN-gamma activation site.

1996 • 48 citations

CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB.

1996 • 47 citations

Structure and expression of mouse germline immunoglobulin γ3 heavy chain transcripts induced by the mitogen lipopolysaccharide

1991 • 22 citations

Overexpression of RelB in transgenic mice does not affect I kappa B alpha levels: differential regulation of RelA and RelB by the inhibitor protein.

1996 • 21 citations

Delayed tyrosine phosphorylation and nuclear expression of STAT1 following antigen receptor stimulation of B lymphocytes.

1996 • 19 citations

Activation of AP-1 in Primary B Lymphocytes by Surface Immunoglobulin Requires de Novo Jun-B Synthesis

1994 • 10 citations