The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.

1990 • 900 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

1992 • 632 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

Nucleotide sequence of a full-length cDNA for mousecytosketetal β-actin raRNA

1986 • 556 citations

A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation.

1993 • 480 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65

1991 • 410 citations

Distinct Mechanisms for Regulation of the Interleukin-8 Gene Involve Synergism and Cooperativity between C/EBP and NF-κB

1993 • 400 citations

Activation of Interleukin-6 Gene Expression through the NF-κB Transcription Factor

1990 • 379 citations

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

1995 • 351 citations

Immunology of Leishmaniasis

1993 • 337 citations

Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes.

1993 • 304 citations

Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation

1994 • 275 citations

Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B.

1993 • 254 citations

Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines.

1993 • 253 citations

Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter.

1993 • 242 citations

Regulation of Tumor Necrosis Factor Alpha Transcription in Macrophages: Involvement of Four κΒ-Like Motifs and of Constitutive and Inducible Forms of NF-κB

1990 • 230 citations

Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages.

1991 • 226 citations

An HMG-like protein that can switch a transcriptional activator to a repressor

1994 • 220 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

Cyclic AMP-independent ATF family members interact with NF-kappa B and function in the activation of the E-selectin promoter in response to cytokines.

1993 • 191 citations

The inhibitory ankyrin and activator Rel proteins

1992 • 185 citations

Activation of mouse macrophages for tumor cell killing. I. Quantitative analysis of interactions between lymphokine and lipopolysaccharide.

1981 • 172 citations

Functional heterogeneity of CD4+ T cells in leishmaniasis

1989 • 171 citations

A simple sensitive bioassay for interleukin-1 which is unresponsive to 103 U/ml of interleukin-2

1987 • 170 citations

The macrophage

1995 • 169 citations

Immunology of leishmaniasis

1992 • 162 citations

Isolation and characterization of infective and non-infective clones of Leishmania tropica

1983 • 151 citations

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.

1996 • 147 citations

Dorsal—ventral embryonic pattern genes of Drosophila

1987 • 128 citations

Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation.

1994 • 125 citations

Cytokine-induced neutrophil chemoattractant mediates neutrophilic alveolitis in rats: association with nuclear factor kappa B activation.

1994 • 107 citations

Molecular Cloning and Characterization of a Novel Rel/NF-χB Family Member Displaying Structural and Functional Homology to NF-χB p50/p105

1992 • 102 citations

The subunit composition of NF-kappa B complexes changes during B-cell development.

1994 • 93 citations

Frequency analysis of lymphokine-secreting CD4+ and CD8+ T cells activated in a graft-versus-host reaction.

1990 • 90 citations

Leishmania-macrophage interactions: multiple receptors, multiple ligands and diverse cellular responses

1993 • 82 citations

Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro

1995 • 78 citations

Immunological regulation and control of experimental leishmaniasis.

1986 • 76 citations

Interleukin-4 but not gamma interferon production correlates with the severity of murine cutaneous leishmaniasis

1993 • 75 citations

The biology of the monocyte system.

1989 • 74 citations

A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 kappa B-related motifs whose activities are repressed in lymphoid cells.

1992 • 71 citations

MURINE CUTANEOUS LEISHMANIASIS: RESISTANCE IN RECONSTITUTED NUDE MICE AND SEVERAL F₁HYBRIDS INFECTED WITH LEISHMANIA TROPICA MAJOR

1983 • 62 citations

Effector functions of activated macrophages against parasites

1993 • 59 citations

Detection of c-rel-related transcripts in mouse hematopoietic tissues, fractionated lymphocyte populations, and cell lines.

1987 • 46 citations

The murine c-rel proto-oncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli.

1990 • 36 citations

Molecular analysis of dorsal-ventral polarity in Drosophila

1988 • 34 citations

Expression of the c-rel and c-myc proto-oncogenes in avian tissues.

1989 • 23 citations

Receptor Insertion into Factor-Dependent Murine Cell Lines to Develop Specific Bioassays for Murine G-CSF and M-CSF and Human GM-CSF

1994 • 19 citations

The inhibitory ankyrin and activator Rel proteins

1992 • 18 citations

Detection of c-rel-Related Transcripts in Mouse Hematopoietic Tissues, Fractionated Lymphocyte Populations, and Cell Lines

1987 • 10 citations

Immunology of leishmaniasis

1992 • 7 citations

Cited By (0)

No citing papers found in database