Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilisers

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

MANIC DEPRESSIVE ILLNESS

1984 • 3,013 citations

Subgenual prefrontal cortex abnormalities in mood disorders

1997 • 2,646 citations

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

Psychopharmacology: The Third Generation of Progress.

1988 • 1,973 citations

Emergent Properties of Networks of Biological Signaling Pathways

1999 • 1,696 citations

Manic-depressive illness

1991 • 1,538 citations

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

1999 • 1,450 citations

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

1996 • 1,299 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

A functional anatomical study of unipolar depression

1992 • 1,266 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

The cellular neurobiology of depression

2001 • 1,169 citations

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

1996 • 1,156 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Neural and developmental actions of lithium: A unifying hypothesis

1989 • 1,005 citations

Protein kinase C

1991 • 914 citations

Localized proton spectroscopy using stimulated echoes

1987 • 814 citations

Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells

2000 • 810 citations

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid Leukemia

1993 • 760 citations

Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system.

1995 • 685 citations

Intricate Regulation of Tyrosine Hydroxylase Activity and Gene Expression

1996 • 673 citations

Neuronal plasticity and survival in mood disorders

2000 • 658 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 • 630 citations

Activation of the Wnt Signaling Pathway: A Molecular Mechanism for Lithium Action

1997 • 627 citations

Complexity in Biological Signaling Systems

1999 • 614 citations

BCL-2 GENE FAMILY IN THE NERVOUS SYSTEM

1997 • 596 citations

The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS

1999 • 495 citations

Role of phosphoinositides in transmembrane signaling.

1990 • 491 citations

Initiation and adaptation: a paradigm for understanding psychotropic drug action

1996 • 489 citations

Advances in second messenger and phosphoprotein research

1992 • 481 citations

The Mood‐Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase‐3

2000 • 434 citations

Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor

1993 • 425 citations

The mechanism of protein kinase C activation

1989 • 423 citations

Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N -methyl- <scp>d</scp> -aspartate receptor-mediated calcium influx

1998 • 422 citations

Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2’s neurotrophic effects?

2000 • 398 citations

The functional neuroanatomy of mood disorders

1997 • 388 citations

Anti-bipolar therapy: mechanism of action of lithium

1999 • 372 citations

Control of transcription factors by signal transduction pathways: the beginning of the end

1992 • 360 citations

Signal sorting and amplification through G protein-coupled receptors

1989 • 338 citations

Neuroplasticity and cellular resilience in mood disorders

2000 • 332 citations

Signal Transduction Pathways

1995 • 328 citations

Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?

1999 • 312 citations

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1996 • 311 citations

Molecular machines integrate coincident synaptic signals

1993 • 310 citations

Reduced Brain Inositol in Lithium-treated Rats

1971 • 309 citations

A current view of tamoxifen for the treatment and prevention of breast cancer

1993 • 297 citations

WNT-7a Induces Axonal Remodeling and Increases Synapsin I Levels in Cerebellar Neurons

1997 • 273 citations

A locus for bipolar affective disorder on chromosome 4p

1996 • 272 citations

Inositol Lipids and Signal Transduction in the Nervous System: An Update

1992 • 260 citations

Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23

1996 • 260 citations

Meta-analyses of Studies of Ventricular Enlargement and Cortical Sulcal Prominence in Mood Disorders

1995 • 255 citations

Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness

1999 • 247 citations

Cellular phosphorylation of tau by GSK-3β influences tau binding to microtubules and microtubule organisation

1996 • 242 citations

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor.

1993 • 229 citations

The role of G proteins in transmembrane signalling

1990 • 228 citations

Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences

1991 • 223 citations

Signaling: cellular insights into the pathophysiology of bipolar disorder

2000 • 212 citations

A manic depressive history

1996 • 211 citations

Substance P and the Neurokinins: Novel Peptide Neurotransmitters in Psychopharmacology

1999 • 208 citations

Mood Stabilizer Combinations: A Review of Safety and Efficacy

1998 • 202 citations

Lithium and brain signal transduction systems

1994 • 200 citations

Altered platelet protein kinase C activity in bipolar affective disorder, manic episode

1993 • 197 citations

Intrinsic Transcriptional Activation-Inhibition Domains of the Polyomavirus Enhancer Binding Protein 2/Core Binding Factor α Subunit Revealed in the Presence of the β Subunit

1998 • 197 citations

Temporal Dissociation Between Lithium-Induced Changes in Frontal Lobe myo-Inositol and Clinical Response in Manic-Depressive Illness

1999 • 191 citations

The AML1/ETO fusion protein activates transcription of BCL-2

1996 • 191 citations

Lithium Increases Transcription Factor Binding to AP‐1 and Cyclic AMP‐Responsive Element in Cultured Neurons and Rat Brain

1997 • 178 citations

Chronic Sodium Valproate Selectively Decreases Protein Kinase C α and ε In Vitro

1994 • 173 citations

A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish

1996 • 173 citations

G proteins: implications for psychiatry

1992 • 172 citations

Enhanced protein kinase C activity and translocation in bipolar affective disorder brains

1996 • 166 citations

Lithium Decreases Membrane‐Associated Protein Kinase C in Hippocampus: Selectivity for the α Isozyme

1993 • 161 citations

Does Lithium Treatment Still Work?

2000 • 161 citations

The effect of long‐term lithium treatment on the mortality of patients with manic‐depressive and schizoaffective illness*

1992 • 156 citations

Clinical and Radiographic Response in a Minority of Patients with Recurrent Malignant Gliomas Treated with High-Dose Tamoxifen

1993 • 152 citations

Lithium decreases turnover of arachidonate in several brain phospholipids

1996 • 150 citations

Second messenger systems and psychoactive drug action: focus on the phosphoinositide system and lithium

1989 • 142 citations

Neurotransmitter Receptors and Phosphoinositide Turnover

1989 • 133 citations

[20] Analysis of altered gene expression by differential display

1995 • 130 citations

Abnormalities in protein kinase C signaling and the pathophysiology of bipolar disorder

1999 • 125 citations

Antidepressant treatments in the 21st century

1998 • 124 citations

Mood stabilizers in the prevention of recurrent affective disorders: a meta‐analysis

1999 • 123 citations

Chronic lithium administration alters a prominent PKC substrate in rat hippocampus

1992 • 121 citations

Abnormalities in G protein-coupled signal transduction pathways in human disease.

1993 • 118 citations

A Linkage Study of Bipolar Illness

1997 • 118 citations

Potentiation by lithium of CMP-phosphatidate formation in carbachol-stimulated rat cerebral-cortical slices and its reversal by myo-inositol

1989 • 115 citations

Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus.

1995 • 111 citations

Time and frequency domain analysis of NMR data compared: An application to 1D ¹H spectra of lipoproteins

1994 • 109 citations

Biochemical, behavioral, and clinical studies of the role of inositol in lithium treatment and depression

1993 • 105 citations

Valproate robustly enhances AP-1 mediated gene expression

1999 • 103 citations

Application of time‐domain fitting in the quantification of in vivo¹H spectroscopic imaging data sets

1992 • 101 citations

Modulation of Protein Kinase C Isozymes and Substrates by Lithium: The Role of Myo-inositol

1996 • 94 citations

Designing Small-Molecule Switches for Protein-Protein Interactions

2000 • 91 citations

Molecular Mechanisms Underlying Mood Stabilization in Manic-Depressive Illness: The Phenotype Challenge

1999 • 90 citations

G protein-coupled receptor structure and function: The impact of disease-causing mutations

1995 • 83 citations

A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish

1998 • 83 citations

Increase in AP-1 Transcription Factor DNA Binding Activity by Valproic Acid

1997 • 82 citations

Local Origin of Fibroblasts deduced from Sarcomas induced in Chimaeras by Implants of Pliable Disks

1971 • 82 citations

Lithium inhibition of protein kinase C activation-induced serotonin release

1989 • 81 citations

G Proteins, Receptors, and Disease

1998 • 72 citations

Lithium Activates the c‐Jun NH₂‐Terminal Kinases In Vitro and in the CNS In Vivo

1999 • 69 citations

Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells: a property of protein kinase C-mediated mood stabilizers.

1998 • 69 citations

Lithium stimulates gene expression through the AP-1 transcription factor pathway

1998 • 69 citations

Lithium Increases Tyrosine Hydroxylase Levels Both In Vivo and In Vitro

1998 • 64 citations

Bipolar Disorder: Biological Models and Their Clinical Application

1997 • 62 citations

Effects of lithium on second messenger systems in the brain.

1992 • 56 citations

A Risk-Benefit Assessment of Tamoxifen Therapy

1993 • 55 citations

Molecular genetics of diabetes mellitus

1995 • 52 citations

G protein mutations in human disease

1993 • 45 citations

Lithium therapy and suicide risk.

1999 • 45 citations

Desensitization of muscarinic stimulated hippocampal cell firing is related to phosphoinositide hydrolysis and inhibited by lithium.

1990 • 45 citations

Evidence that a proconvulsant action of lithium is mediated by inhibition of myo-inositol phosphatase in mouse brain

1991 • 44 citations

Do animal models have a place in the genetic analysis of quantitative human behavioural traits?

1996 • 42 citations

Intracerebroventricularmyo-inositol antagonizes lithium-induced suppression of rearing behaviour in rats

1990 • 39 citations

Phosphoinositide Metabolism and Hormone Action

1989 • 37 citations

Circadian variation in rat brain AP-1 DNA binding activity after cholinergic stimulation: modulation by lithium

1995 • 34 citations

Lithium Attenuates Nerve Growth Factor–Induced Activation of AP-1 DNA Binding Activity in PC12 Cells

1997 • 30 citations

Mood genes: hunting for origins of mania and depression

1999 • 26 citations

Bipolar Medications: Mechanisms of Action

2000 • 26 citations

Antidegenerative effects of Mg(2+)-valproate in cultured cerebellar neurons.

1995 • 26 citations

AP-1 and NF-κ B stimulated by carbachol in human neuroblastoma SH-SY5Y cells are differentially sensitive to inhibition by lithium

1997 • 23 citations

Signal Transduction Abnormalities in Bipolar Affective Disorder

2000 • 23 citations

The genetics of hypertension

1995 • 21 citations

Signal Transduction Abnormalities in Bipolar Affective Disorder

2003 • 18 citations

Disruption of phosphoinositide signalling by lithium

1992 • 17 citations

Bipolar Medications: Mechanisms of Action

2001 • 12 citations

Cerebral Signal Transduction

2000 • 7 citations