Molecular genetics of diabetes mellitus

Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

1989 • 3,458 citations

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

1992 • 3,255 citations

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

1988 • 2,463 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies

1990 • 2,006 citations

The insulin signaling system.

1994 • 1,733 citations

A second-generation linkage map of the human genome

1992 • 1,721 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness

1992 • 1,103 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Familial Hyperglycemia Due to Mutations in Glucokinase -- Definition of a Subtype of Diabetes Mellitus

1993 • 737 citations

A Molecular Basis for MHC Class II—Associated Autoimmunity

1988 • 707 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Concordance for Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland

1992 • 635 citations

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

1992 • 620 citations

Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

1992 • 612 citations

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

1992 • 610 citations

A Subtype of Diabetes Mellitus Associated with a Mutation of Mitochondrial DNA

1994 • 557 citations

Assessing the role of HLA-linked and unlinked determinants of disease.

1987 • 548 citations

A genetic map of the mouse with 4,006 simple sequence length polymorphisms

1994 • 543 citations

Birthweight and adult health outcomes in a biethnic population in the USA

1994 • 526 citations

Concordance for Type 2 (non-insulin-dependent) diabetes mellitus in male twins

1987 • 519 citations

The Murine Autoimmune Diabetes Model: NOD and Related Strains

1992 • 498 citations

Genetic analysis of autoimmune type 1 diabetes mellitus in mice

1991 • 494 citations

Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites

1990 • 475 citations

A Difference Between the Inheritance of Classical Juvenile-onset and Maturity-onset Type Diabetes of Young People

1975 • 439 citations

The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

1986 • 424 citations

Linkage of type 2 diabetes to the glucokinase gene

1992 • 386 citations

Differences in Risk of Insulin-Dependent Diabetes in Offspring of Diabetic Mothers and Diabetic Fathers

1984 • 386 citations

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

1991 • 378 citations

Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus.

1988 • 371 citations

A Comprehensive Genetic Linkage Map of the Human Genome

1992 • 355 citations

Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus

1993 • 333 citations

Chromosome–specific microsatellite sets for fluorescence–based, semi–automated genome mapping

1994 • 304 citations

Insulin prophylaxis in individuals at high risk of type 1 diabetes

1993 • 303 citations

Rad: a Member of the Ras Family Overexpressed in Muscle of Type II Diabetic Humans

1993 • 301 citations

Polygenic control of autoimmune diabetes in nonobese diabetic mice

1993 • 298 citations

Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.

1994 • 294 citations

Mutations in the Insulin Receptor Gene

1992 • 294 citations

Three Recessive Loci Required for Insulin-Dependent Diabetes in Nonobese Diabetic Mice

1987 • 293 citations

Mapping Genes in Diabetes: Genetic Epidemiological Perspective

1990 • 290 citations

Application of automated DNA sizing technology for genotyping microsatellite loci

1992 • 279 citations

Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q.

1991 • 277 citations

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR

1993 • 271 citations

Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping

1989 • 238 citations

Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse.

1987 • 222 citations

The New Elements of Insulin Signaling: Insulin Receptor Substrate-1 and Proteins With SH2 Domains

1993 • 221 citations

Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.

1992 • 221 citations

The significance of the concordance rate for Type 1 (insulin-dependent) diabetes in identical twins

1988 • 220 citations

A Comprehensive Genetic Linkage Map of the Human Genome

1992 • 213 citations

Maternally inherited diabetes and deafness is a distinct subtype of diabetes and associates with a single point mutation in the mitochondrial tRNA Leu(UUR) gene

1994 • 207 citations

A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus

1984 • 205 citations

Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.

1993 • 202 citations

A Unified Hypothesis for the Complex Genetics of HLA Associations With IDDM

1990 • 190 citations

Diabetes mellitus due to viruses ? some recent developments

1993 • 189 citations

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

1993 • 186 citations

Association between Polymorphism of the Glycogen Synthase Gene and Non-Insulin-Dependent Diabetes Mellitus

1993 • 179 citations

Prevention or delay of Type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide

1991 • 176 citations

Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1

1991 • 171 citations

New perspectives on pancreatic islet glucokinase

1984 • 165 citations

Lack of Immune Responsiveness to Bovine Serum Albumin in Insulin-Dependent Diabetes

1993 • 163 citations

Persistent MHV (mouse hepatitis virus) infection reduces the incidence of diabetes mellitus in non-obese diabetic mice

1991 • 147 citations

Early Introduction of Dairy Products Associated with Increased Risk of IDDM in Finnish Children

1993 • 146 citations

The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome

1991 • 143 citations

Insulin gene region–encoded susceptibility to type 1 diabetes is not restricted to HLA–DR4–positive individuals

1992 • 138 citations

Islet cell autoantigens in insulin-dependent diabetes.

1993 • 136 citations

Apparent Epidemic of Insulin-Dependent Diabetes Mellitus in Midwestern Poland

1987 • 135 citations

Can We Really Predict IDDM?

1993 • 129 citations

Linkage of Chromosomal Markers on 4q With a Putative Gene Determining Maximal Insulin Action in Pima Indians

1993 • 127 citations

Insulin receptor substrate-1 variants in non-insulin-dependent diabetes.

1994 • 125 citations

Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.

1994 • 123 citations

Mitochondrial diabetes mellitus: Prevalence and clinical characterization of diabetes due to mitochondrial tRNALeU(UUR) gene mutation in Japanese patients

1994 • 120 citations

Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM).

1993 • 118 citations

A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people

1975 • 107 citations

Dose Effect of Cis- and Trans-Encoded HLA-DQαβ Heterodimers in IDDM Susceptibility

1992 • 105 citations

Linkage on Chromosome 3 of Autoimmune Diabetes and Defective Fc Receptor for IgG in NOD mice

1993 • 103 citations

Dose effect of cis- and trans-encoded HLA-DQ alpha beta heterodimers in IDDM susceptibility

1992 • 103 citations

Molecular Scanning of the Insulin Receptor Gene in Syndromes of Insulin Resistance

1994 • 101 citations

Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11

1985 • 100 citations

Identification of Glucokinase Mutations in Subjects With Gestational Diabetes Mellitus

1993 • 98 citations

Detection of Mutations in Insulin-Receptor Gene in NIDDM Patients by Analysis of Single-Stranded Conformation Polymorphisms

1991 • 95 citations

HLA and Insulin-Dependent Diabetes. A protective perspective

1992 • 94 citations

Major Gene Effect for Insulin Levels in Familial NIDDM Pedigrees

1992 • 86 citations

Localization of a Type I Diabetes Susceptibility Locus to the Variable Tandem Repeat Region Flanking the Insulin Gene

1993 • 86 citations

Mapping genes in diabetes. Genetic epidemiological perspective

1990 • 84 citations

Metabolic studies in unaffected co-twins of non-insulin-dependent diabetics.

1981 • 83 citations

Mitochondrial gene defects in patients with NIDDM

1994 • 81 citations

Insulin signalling: the role of insulin receptor substrate 1

1994 • 76 citations

A unified hypothesis for the complex genetics of HLA associations with IDDM

1990 • 74 citations

Mononucleotide repeats are an abundant source of length variants in mouse genomic DNA

1991 • 73 citations

Normal Insulin-Receptor cDNA Sequence in Pima Indians With NIDDM

1989 • 69 citations

Glucokinase Gene is Genetic Marker for NIDDM in American Blacks

1992 • 68 citations

Linkage Analysis and Molecular Scanning of Glucokinase Gene in NIDDM Families

1993 • 68 citations

Effect of nicotinamide therapy upon B-cell function in newly diagnosed Type 1 (insulin-dependent) diabetic patients

1989 • 67 citations

Genetic analysis of IDDM: Summary of GAW5 IDDM results

1989 • 64 citations

Molecular Scanning of Insulin-Responsive Glucose Transporter (GLUT4) Gene in NIDDM Subjects

1991 • 64 citations

Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children

1994 • 63 citations

Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians

1993 • 57 citations

NIDDM Associated With Mutation in Tyrosine Kinase Domain of Insulin Receptor Gene

1992 • 56 citations

High-resolution linkage mapping for susceptibility genes in human polygenic disease: insulin-dependent diabetes mellitus and chromosome 11q.

1991 • 55 citations

Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition.

1990 • 54 citations

HLA-DQB1 Alleles and Absence of Asp 57 as Susceptibility Factors of IDDM in Finland

1991 • 53 citations

Apparent epidemic of insulin-dependent diabetes mellitus in Midwestern Poland

1987 • 52 citations

A genetic marker at the glucokinase gene locus for Type 2 (non-insulin-dependent) diabetes mellitus in Mauritian Creoles

1992 • 50 citations

Six Mutations in the Glucokinase Gene Identified in MODY by Using a Nonradioactive Sensitive Screening Technique

1994 • 50 citations

Polymorphisms of GLUT2 and GLUT4 Genes: Use in Evaluation of Genetic Susceptibility to NIDDM in Blacks

1990 • 50 citations

Maternally inherited diabetes and deafness is a distinct subtype of diabetes and associates with a single point mutation in the mitochondrial tRNA(Leu(UUR)) gene

1994 • 48 citations

Human GLUT4/Muscle-Fat Glucose-Transporter Gene: Characterization and Genetic Variation

1992 • 48 citations

A Practical Approach to Identification of Susceptibility Genes for IDDM

1992 • 47 citations

Insulin Secretion in Adult Rats After Intrauterine Exposure to Mild Hyperglycemia During Late Gestation

1991 • 47 citations

Chromosome 4q Locus Associated With Insulin Resistance in Pima Indians: Studies in Three European NIDDM Populations

1994 • 46 citations

The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains

1993 • 46 citations

Linkage Analysis of Acute Insulin Secretion With GLUT2 and Glucokinase in Pima Indians and the Identification of a Missense Mutation in GLUT2

1994 • 43 citations

Molecular scanning of the insulin receptor gene in syndromes of insulin resistance

1994 • 40 citations

Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients

1994 • 40 citations

Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a welsh type 2 (non-insulin-dependent) diabetic population

1992 • 39 citations

Can we really predict IDDM?

1993 • 38 citations

Increasing prevalence of juvenile onset Type 1 (insulin-dependent) diabetes mellitus in Sardinia: the military service approach

1993 • 37 citations

Insulin and Glucose Levels and Prevalence of Glucose Intolerance in Pedigrees With Multiple Diabetic Siblings

1991 • 37 citations

Genetics of non-insulin dependent diabetes mellitus

1991 • 36 citations

Early introduction of dairy products associated with increased risk of IDDM in Finnish children. The Childhood in Diabetes in Finland Study Group

1993 • 36 citations

Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms

1991 • 35 citations

The incidence of male childhood Type 1 (insulin-dependent) diabetes mellitus is rising rapidly in The Netherlands

1992 • 35 citations

Increasing incidence of early onset Type 1 (insulin-dependent) diabetes mellitus: a study of Danish male birth cohorts

1992 • 34 citations

HLA and insulin-dependent diabetes. A protective perspective

1992 • 33 citations

Linkage analysis and molecular scanning of glucokinase gene in NIDDM families

1993 • 33 citations

Increasing Incidence of Type I Diabetes in The Netherlands: The second nationwide study among children under 20 years of age

1994 • 33 citations

Metabolic Alterations in Adulthood After Intrauterine Development in Mothers With Mild Diabetes

1991 • 33 citations

Linkage Analysis of Glucokinase Gene With NIDDM in Caucasian Pedigrees

1992 • 32 citations

Sequence Variations of the Glucokinase Gene in Japanese Subjects With NIDDM

1993 • 31 citations

Glucokinase gene is genetic marker for NIDDM in American blacks

1992 • 31 citations

Association between a restriction fragment length polymorphism at the liver/islet cell (GluT 2) glucose transporter and familial Type 2 (non-insulin-dependent) diabetes mellitus

1991 • 30 citations

Polymorphic Microsatellite Repeat Markers at the Glucokinase Gene Locus Are Positively Associated With NIDDM in Japanese

1993 • 30 citations

9 Diabetes secondary to genetic disorders

1992 • 29 citations

Simple tandem repeat DNA polymorphism in the human glycogen synthase gene is associated with NIDDM in Japanese subjects

1994 • 29 citations

Identification of glucokinase mutations in subjects with gestational diabetes mellitus

1993 • 28 citations

Normal insulin-receptor cDNA sequence in Pima Indians with NIDDM

1989 • 27 citations

The genetics of diabetes.

1987 • 27 citations

A practical approach to identification of susceptibility genes for IDDM

1992 • 26 citations

The Emperor's New Genes: 1993 RD Lawrence Lecture

1994 • 26 citations

Search for a Third Susceptibility Gene for Maturity-Onset Diabetes of the Young: Studies With Eleven Candidate Genes

1994 • 25 citations

Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene

1993 • 24 citations

HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland

1991 • 23 citations

Chromosome 4q locus associated with insulin resistance in Pima Indians. Studies in three European NIDDM populations

1994 • 22 citations

Linkage analysis of acute insulin secretion with GLUT2 and glucokinase in Pima Indians and the identification of a missense mutation in GLUT2

1994 • 22 citations

Multiple restriction fragment length polymorphisms at the GLUT2 locus: GLUT2 haplotypes for genetic analysis of Type 2 (non-insulin-dependent) diabetes mellitus

1991 • 22 citations

Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.

1994 • 22 citations

Linkage analysis of maturity-onset diabetes of the young (MODY): genetic heterogeneity and nonpenetrance.

1992 • 21 citations

Linkage analysis of the glucokinase locus in familial Type 2 (non-insulin-dependent) diabetic pedigrees

1993 • 20 citations

Glucokinase Gene Polymorphisms: a Genetic Marker for Glucose Intolerance in a Cohort of Elderly Finnish Men

1994 • 20 citations

Linkage Analysis of Insulin-Receptor Gene in Familial NIDDM

1992 • 20 citations

Sequence variations of the glucokinase gene in Japanese subjects with NIDDM

1993 • 19 citations

Major gene effect for insulin levels in familial NIDDM pedigrees

1992 • 19 citations

Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique

1994 • 18 citations

Polymorphisms of GLUT2 and GLUT4 genes. Use in evaluation of genetic susceptibility to NIDDM in blacks

1990 • 18 citations

Interaction between T cell receptor beta chain and immunoglobulin heavy chain region genes in susceptibility to insulin-dependent diabetes mellitus.

1991 • 17 citations

Multigenic Basis for Type I Diabetes: Association of HRAS1 Polymorphism With HLA-DR3,DQw2/DR4,DQw8

1990 • 16 citations

Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation

1992 • 16 citations

Polymorphic microsatellite repeat markers at the glucokinase gene locus are positively associated with NIDDM in Japanese

1993 • 16 citations

HLA-DR and the 5′ insulin gene polymorphism in insulin-dependent diabetes

1991 • 15 citations

Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects

1991 • 15 citations

Linkage analysis of glucokinase gene with NIDDM in Caucasian pedigrees

1992 • 15 citations

Mouse or Man: Is GAD the cause of type I diabetes?

1994 • 14 citations

Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11

1991 • 14 citations

Insulin and glucose levels and prevalence of glucose intolerance in pedigrees with multiple diabetic siblings

1991 • 13 citations

Two microsatellite repeat polymorphisms flanking opposite ends of the human glucokinase gene: use in haplotype analysis of Welsh Caucasians with Type 2 (non-insulin-dependent) diabetes mellitus

1993 • 13 citations

Mouse microsatellites from a flow-sorted 4:6 Robertsonian chromosome

1992 • 12 citations

NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene

1992 • 11 citations

Search for a third susceptibility gene for maturity-onset diabetes of the young. Studies with eleven candidate genes

1994 • 10 citations

Linkage analysis of insulin-receptor gene in familial NIDDM

1992 • 10 citations

Mutations in the Glucokinase Gene are not a Major Cause of Late‐onset Type 2 (Non‐insulin‐dependent) Diabetes Mellitus in Japanese subjects

1994 • 9 citations

Insulin-Receptor cDNA Sequence in NIDDM Patient Homozygous for Insulin-Receptor Gene RFLP

1991 • 7 citations

Multigenic basis for type I diabetes. Association of HRAS1 polymorphism with HLA-DR3, DQw2/DR4, DQw8

1990 • 6 citations

Insulin-receptor cDNA sequence in NIDDM patient homozygous for insulin-receptor gene RFLP

1991 • 3 citations

Summary of Talk in Orlando Protection Against Insulin-Dependent Diabetes Mellitus

1993 • 2 citations