Signaling: cellular insights into the pathophysiology of bipolar disorder

J Neuropsychiatry Clin Neurosci

1992 • 3,756 citations

MANIC DEPRESSIVE ILLNESS

1984 • 3,013 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Subgenual prefrontal cortex abnormalities in mood disorders

1997 • 2,646 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

Emergent Properties of Networks of Biological Signaling Pathways

1999 • 1,696 citations

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

1999 • 1,450 citations

Social Zeitgebers and Biological Rhythms

1988 • 663 citations

Complexity in Biological Signaling Systems

1999 • 614 citations

Enhancement of Hippocampal Neurogenesis by Lithium

2000 • 613 citations

Manic-Depressive Illness

1991 • 573 citations

Neurobiology of Mental Illness

2011 • 532 citations

NEUROBIOLOGY OF MOOD DISORDERS

2017 • 466 citations

Can antidepressants cause mania and worsen the course of affective illness?

1987 • 408 citations

Anti-bipolar therapy: mechanism of action of lithium

1999 • 372 citations

Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic–depressive illness

2000 • 352 citations

Neurobiology of Mental Illness.

2000 • 344 citations

Circadian rhythms in psychiatry

1984 • 317 citations

Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?

1999 • 312 citations

Molecular machines integrate coincident synaptic signals

1993 • 310 citations

Molecular Clock Genes in Man and Lower Animals Possible Implications for Circadian Abnormalities in Depression

2000 • 268 citations

Neurobiology of Mood Disorders

1985 • 255 citations

Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness

1999 • 247 citations

Are Schizophrenic and Bipolar Disorders Related? A Review of Family and Molecular Studies

2019 • 245 citations

Chronic Cocaine Treatment Decreases Levels of the G Protein Subunits G_iα and G_oα in Discrete Regions of Rat Brain

1990 • 230 citations

Lithium and brain signal transduction systems

1994 • 200 citations

Altered platelet protein kinase C activity in bipolar affective disorder, manic episode

1993 • 197 citations

Chronic Antidepressant Administration Alters the Subcellular Distribution of Cyclic AMP‐Dependent Protein Kinase in Rat Frontal Cortex

1989 • 196 citations

Temporal Dissociation Between Lithium-Induced Changes in Frontal Lobe myo-Inositol and Clinical Response in Manic-Depressive Illness

1999 • 191 citations

Lithium Increases Transcription Factor Binding to AP‐1 and Cyclic AMP‐Responsive Element in Cultured Neurons and Rat Brain

1997 • 178 citations

G proteins: implications for psychiatry

1992 • 172 citations

Enhanced protein kinase C activity and translocation in bipolar affective disorder brains

1996 • 166 citations

Cerebral Cortex G_sα Protein Levels and Forskolin‐Stimulated Cyclic AMP Formation Are Increased in Bipolar Affective Disorder

1993 • 159 citations

Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices.

1998 • 151 citations

High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder

1997 • 145 citations

Effects of lithium in vitro and ex vivo on components of the adenylate cyclase system in membranes from the cerebral cortex of the rat

1987 • 144 citations

The American Psychiatric Press Textbook of Psychopharmacology

1995 • 142 citations

Receptor‐Mediated Activation of G Proteins Is Increased in Postmortem Brains of Bipolar Affective Disorder Subjects

1996 • 128 citations

A two-dimensional threshold model of seasonal bipolar affective disorder.

1987 • 125 citations

Molecular endocrinology : basic concepts and clinical correlations

1995 • 123 citations

Second Messenger‐Regulated Protein Kinases in the Brain

2000 • 122 citations

Chronic lithium administration alters a prominent PKC substrate in rat hippocampus

1992 • 121 citations

A Naturally Occurring Amino Acid Substitution of the Human Serotonin 5‐HT_2A Receptor Influences Amplitude and Timing of Intracellular Calcium Mobilization

1997 • 113 citations

Regulation of Signal Transduction Pathways and Gene Expression by Mood Stabilizers and Antidepressants

1999 • 108 citations

Reduced [³H]Cyclic AMP Binding in Postmortem Brain from Subjects with Bipolar Affective Disorder

1997 • 107 citations

Chronic lithium regulates the expression of adenylate cyclase and Gi-protein alpha subunit in rat cerebral cortex.

1991 • 98 citations

The Mechanisms of Action of Lithium

1991 • 96 citations

A bimodal model of the mechanism of action of lithium

1999 • 95 citations

Lithium regulates PKC‐mediated intracellular cross‐talk and gene expression in the CNS in vivo

2000 • 92 citations

Contemporary Issues in Modeling Psychopathology

2000 • 92 citations

Molecular Mechanisms Underlying Mood Stabilization in Manic-Depressive Illness: The Phenotype Challenge

1999 • 90 citations

The American Psychiatric Press Textbook of Psychopharmacology

1998 • 90 citations

Attenuation of Cyclic AMP Production by Carbamazepine

1996 • 83 citations

Lithium and the brain: a psychopharmacological strategy to a molecular basis for manic depressive illness

1994 • 80 citations

Elevated basal and thapsigargin-stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay

1999 • 77 citations

Molecular Endocrinology

1994 • 74 citations

Chronic Lithium‐Induced Down‐Regulation of MARCKS in Immortalized Hippocampal Cells: Potentiation by Muscarinic Receptor Activation

1996 • 72 citations

G Proteins, Receptors, and Disease

1998 • 72 citations

Increased Cyclic AMP‐Dependent Protein Kinase Activity in Postmortem Brain from Patients with Bipolar Affective Disorder

1999 • 71 citations

Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells: a property of protein kinase C-mediated mood stabilizers.

1998 • 69 citations

Sensitization to psychostimulants and stress after injection of pertussis toxin into the A10 dopamine region.

1991 • 68 citations

In Vivo Evidence that Lithium Inactivates G_i Modulation of Adenylate Cyclase in Brain

1992 • 67 citations

The calcium second messenger system in bipolar disorders: data supporting new research directions

1992 • 66 citations

Abnormalities of cAMP signaling in affective disorders: implications for pathophysiology and treatment

2000 • 63 citations

Bipolar Disorder: Biological Models and Their Clinical Application

1997 • 62 citations

The effects of lithium in vitro and ex vivo on adenylate cyclase in brain are exerted by distinct mechanisms

1989 • 62 citations

Increased Gαq/11 immunoreactivity in postmortem occipital cortex from patients with bipolar affective disorder

1997 • 60 citations

Effects of lithium on second messenger systems in the brain.

1992 • 56 citations

Differential effect of lithium on fos protooncogene expression mediated by receptor and postreceptor activators of protein kinase C and cyclic adenosine monophosphate: Model for its antimanic action

1991 • 51 citations

β‐Adrenoceptor binding defects in cell lines from families with manic‐depressive disorder

1984 • 50 citations

Lithium and the cell : pharmacology and biochemistry

1991 • 50 citations

Effects of lithium on receptor-mediated activation of G proteins in rat brain cortical membranes

1999 • 50 citations

Cyclic AMP responsive element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cells

1999 • 46 citations

Abnormal G protein αs- and αi2-subunit mRNA expression in bipolar affective disorder

1998 • 45 citations

Long-lasting change in the membrane-associated protein kinase C activity in the hippocampal kindled rat

1991 • 39 citations

The cyclic AMP second messenger system in man: The effects of heredity, hormones, drugs, aluminum, age and disease on signal amplification

1986 • 35 citations

The phospholipase C/protein kinase C pathway is involved in cathepsin G-induced human platelet activation: comparison with thrombin

1996 • 31 citations

G-proteins : signal transduction and disease

1992 • 31 citations

Altered Rap1 endogenous phosphorylation and levels in platelets from patients with bipolar disorder

2000 • 30 citations

Lithium and the Cell

1986 • 29 citations

Bipolar Medications: Mechanisms of Action

2000 • 26 citations

American Psychiatric Press Textbook of Psychopharmacology, 2nd ed.

1998 • 26 citations

Increased adenylyl cyclase type 1 mRNA, but not adenylyl cyclase type 2 in the rat hippocampus following antidepressant treatment

2000 • 26 citations

Regulation of Endogenous ADP‐Ribosylation by Acute and Chronic Lithium in Rat Brain

1995 • 23 citations

Animal Models of Bipolar Disorder: From a Single Episode to Progressive Cycling Models

2000 • 22 citations

Signal Transduction by Platelet Adenylate Cyclase: Alterations in Depressed Patients May Reflect Impairment in the Coordinated Integration of Cellular Signals (Coincidence Detection) 11This work was presented in part at the Annual Meeting of the American Psychiatric Association, New York, NY, May 7, 1996.

1998 • 19 citations

Role of Receptor Coupling to Phosphoinositide Metabolism in the Therapeutic Action of Lithium

1987 • 19 citations

Region-Selective Effects of Long-Term Lithium and Carbamazepine Administration on Cyclic AMP Levels in Rat Brain

1999 • 17 citations

Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils

1996 • 15 citations

Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in platelets: a new approach

1995 • 15 citations

Lithium, But Not Carbamazepine, Potentiates Hyperactivity Induced by Intra-accumbens Cholera Toxin

1998 • 14 citations

Receptor coupling to G proteins: Interactions not affected by lithium

1991 • 13 citations

Mechanism of Action of Lithium: Comparison and Contrast with Carbamazepine

1991 • 13 citations

Mood stabilizers have differential effects on endogenous ADP ribosylation in C6 glioma cells

1996 • 9 citations

Mechanism of action of lithium

1988 • 6 citations

G Proteins, Receptors and Disease

1998 • 2 citations