Do animal models have a place in the genetic analysis of quantitative human behavioural traits?

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

Précis ofThe neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system

1982 • 4,511 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

The psychology of fear and stress

1988 • 3,188 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A

1993 • 1,620 citations

Tests for emotionality in rats and mice: A review

1973 • 1,561 citations

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat

1986 • 1,509 citations

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,336 citations

Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality.

1934 • 1,281 citations

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

1995 • 1,211 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

The Genetic Basis of Complex Human Behaviors

1994 • 1,028 citations

Comparison between the behavioural effects of septal and hippocampal lesions: A review

1983 • 666 citations

Convergent Domestication of Cereal Crops by Independent Mutations at Corresponding Genetic Loci

1995 • 607 citations

Positional cloning moves from perditional to traditional

1995 • 603 citations

Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase

1995 • 603 citations

cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase

1994 • 501 citations

A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity

1995 • 465 citations

A Simple Genetic Basis for a Complex Psychological Trait in Laboratory Mice

1995 • 447 citations

Genetic Animal Models of Alcohol and Drug Abuse

1994 • 435 citations

An international two–stage genome–wide search for schizophrenia susceptibility genes

1995 • 385 citations

Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene.

1994 • 378 citations

X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism.

1993 • 363 citations

Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect.

1995 • 347 citations

Selection for high rates and low rates of avoidance conditioning in the rat

1965 • 340 citations

Emotional behavior in the rat. III. The relationship between emotionality and ambulatory activity.

1936 • 322 citations

Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat

1996 • 300 citations

Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib–pair linkage analysis

1995 • 279 citations

Response to 30 generations of selection for open-field activity in laboratory mice

1978 • 264 citations

Locomotor activity, defecation score and corticosterone levels during an openfield exposure: A comparison among individually and group-housed rats, and genetically selected rat lines

1981 • 229 citations

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33

1995 • 211 citations

QTL mapping in rice

1995 • 194 citations

Correlative effects of psychogenetic selection: A study of the roman high and low avoidance strains of rats

1964 • 191 citations

Genes with triplet repeats: candidate mediators of neuropsychiatric disorders

1993 • 187 citations

Hereditary covariations of neuronal circuitry and behavior: Correlations between the proportions of hippocampal synaptic fields in the regio inferior and two-way avoidance in mice and rats

1983 • 178 citations

Chromosome 18 DNA markers and manic-depressive illness : evidence for a susceptibility gene

1994 • 169 citations

Genetic and ontogenetic determinants of adult behavior in the rat.

1963 • 133 citations

Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats

1993 • 127 citations

Taking stock of complex trait genetics in mice

1995 • 119 citations

Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM).

1993 • 118 citations

Mapping and manipulating quantitative traits in maize

1995 • 106 citations

Individual Hippocampal Mossy Fiber Distribution in Mice Correlates with Two-Way Avoidance Performance

1981 • 98 citations

The American soldier: Combat and its aftermath. (Studies in social psychology in World War II), Vol. 2

1949 • 91 citations

The role of subicular outputs in the development of the partial reinforcement extinction effect

1989 • 61 citations

The Effect on Avoidance Response Extinction in Rats of CS Continuation and Emotional Constitution

1963 • 34 citations

Selection for two-way avoidance deficit inhibits shock-induced fighting in the rat

1980 • 34 citations

The possible role of locus coeruleus noradrenergic activity in anxiety-panic.

1986 • 26 citations

Animal models for Clinical Psychopharmacology: Depression, Anxiety, Schizophrenia

1990 • 19 citations

Emotional correlates of selection for avoidance learning in rats

1980 • 8 citations