Signal sorting and amplification through G protein-coupled receptors

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

The GTP-binding protein, Go9 regulates neuronal calcium channels

1987 • 910 citations

G _olf : an Olfactory Neuron Specific-G Protein Involved in Odorant Signal Transduction

1989 • 863 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

1987 • 751 citations

cDNA eloping of bovine substance-K receptor through oocyte expression system

1987 • 748 citations

Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure

1989 • 745 citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).

1988 • 674 citations

Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

1988 • 669 citations

Selective Amplification And Cloning Of Four New Members Of The G Protein-coupled Receptor Family

1989 • 647 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins

1985 • 626 citations

Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.

1982 • 618 citations

The role of guanosine 5′-triphosphate in polypeptide chain elongation

1978 • 559 citations

A G Protein Directly Regulates Mammalian Cardiac Calcium Channels

1987 • 551 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

The regulatory component of adenylate cyclase. Purification and properties.

1981 • 505 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein

1989 • 491 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site.

1985 • 457 citations

Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments.

1979 • 448 citations

Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G _k

1987 • 441 citations

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

1989 • 438 citations

The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway

1987 • 431 citations

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.

1988 • 400 citations

An M2 Muscarinic Receptor Subtype Coupled to Both Adenylyl Cyclase and Phosphoinositide Turnover

1987 • 398 citations

Identification of residues required for ligand binding to the beta-adrenergic receptor.

1987 • 398 citations

Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the gamma phosphate of GTP.

1987 • 383 citations

Isolation and characterization of the human Gs alpha gene.

1988 • 379 citations

Human cDNA clones for four species of G alpha s signal transduction protein.

1986 • 370 citations

Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.

1987 • 359 citations

Structural features required for ligand binding to the beta-adrenergic receptor.

1987 • 358 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition.

1984 • 345 citations

Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.

1987 • 344 citations

Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

1982 • 336 citations

ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.

1984 • 327 citations

Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

1987 • 318 citations

Role of Cyclic Amp in Cell Function

1970 • 317 citations

Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins.

1985 • 314 citations

The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits

1988 • 306 citations

Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel

1989 • 299 citations

Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization

1985 • 284 citations

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.

1988 • 273 citations

G protein multiplicity in eukaryotic signal transduction systems

1988 • 267 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes.

1984 • 265 citations

A single amino acid substitution in rhodopsin (lysine 248—-leucine) prevents activation of transducin.

1988 • 260 citations

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

1987 • 259 citations

Purification of the catalyst of adenylate cyclase.

1986 • 259 citations

Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell

1989 • 259 citations

The purified alpha subunits of Go and Gi from bovine brain require beta gamma for association with phospholipid vesicles.

1986 • 253 citations

Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin.

1988 • 251 citations

Identification of receptor contact site involved in receptor–G protein coupling

1987 • 249 citations

The opsin family of proteins

1986 • 245 citations

The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit.

1983 • 237 citations

Newly Identified Brain Potassium Channels Gated by the Guanine Nucleotide Binding Protein G _o

1988 • 236 citations

Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by beta-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesicles.

1986 • 225 citations

Selective coupling with K+ currents of muscarinic acetylcholine receptor subtypes in NG108-15 cells

1988 • 216 citations

Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin.

1984 • 214 citations

Millisecond activation of transducin in the cyclic nucleotide cascade of vision

1984 • 211 citations

Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit.

1988 • 207 citations

Reconstitution of catecholamine-stimulated adenylate cyclase activity using three purified proteins.

1985 • 206 citations

Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues.

1988 • 205 citations

Family of G protein α chains: amphipathic analysis and predicted structure of functional domains

1986 • 197 citations

Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning.

1987 • 185 citations

Differential G protein—mediated coupling of neurotransmitter receptors to Ca2+ channels in rat dorsal root ganglion neurons in vitro

1989 • 180 citations

Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling

1988 • 167 citations

Molecular distinction between muscarinic acetylcholine receptor subtypes

1987 • 162 citations

Regulation of insulin-stimulated glucose transport in the isolated rat adipocyte. cAMP-independent effects of lipolytic and antilipolytic agents.

1987 • 158 citations

Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles.

1984 • 158 citations

A G Protein γ Subunit Shares Homology with ras Proteins

1989 • 153 citations

Propylbenzilylcholine Mustard Labels an Acidic Residue in Transmembrane Helix 3 of the Muscarinic Receptor

1989 • 146 citations

Guanine nucleotide‐controlled interactions between components of adenylate cyclase

1979 • 144 citations

GTPase activity of the stimulatory GTP-binding regulatory protein of adenylate cyclase, Gs. Accumulation and turnover of enzyme-nucleotide intermediates.

1985 • 143 citations

Constitutive mutants in the yeast pheromone response: Ordered function of the gene products

1989 • 143 citations

Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel.

1988 • 141 citations

G protein .beta..gamma. subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of .alpha. subunits by pertussis toxin but differential interactions with Gs.alpha.

1989 • 139 citations

The catecholamine binding site of the beta-adrenergic receptor is formed by juxtaposed membrane-spanning domains.

1988 • 121 citations

A second form of the beta subunit of signal-transducing G proteins.

1987 • 118 citations

Catalytic unit of adenlyate cyclase: purification and identification by affinity crosslinking.

1985 • 115 citations

G protein-effector coupling: binding of rod phosphodiesterase inhibitory subunit to transducin

1989 • 104 citations

Adenylate cyclase from bovine brain cortex: purification and characterization of the catalytic unit.

1985 • 103 citations

Activation of retinal rod cyclic GMP‐phosphodiesterase by transducin: Characterization of the complex formed by phosphodiesterase inhibitor and transducin α‐subunit

1986 • 102 citations

Inhibition of 3-O-methylglucose transport in human erythrocytes by forskolin.

1985 • 97 citations

Molecular Mechanisms of Coupling in Hormone Receptor‐Adenylate Cyclase Systems

1982 • 95 citations

Inhibition of magnesium uptake by beta-adrenergic agonists and prostaglandin E1 is not mediated by cyclic AMP.

1980 • 94 citations

The hydrophobic tryptic core of the beta-adrenergic receptor retains Gs regulatory activity in response to agonists and thiols.

1987 • 87 citations

Molecular model of the G protein alpha subunit based on the crystal structure of the HRAS protein.

1989 • 82 citations

The regulatory GTPase cycle of turkey erythrocyte adenylate cyclase.

1977 • 78 citations

Functional differences in the .beta..gamma. complexes of transducin and the inhibitory guanine nucleotide regulatory protein

1987 • 76 citations

Occurrence of a hormone-sensitive inhibitory coupling component of the adenylate cyclase in S49 lymphoma cyc- variants.

1983 • 72 citations

Chemical cross-linking of bovine retinal transducin and cGMP phosphodiesterase.

1988 • 71 citations

Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.

1986 • 70 citations

Alpha-subunit of Gs directly activates cardiac calcium channels in lipid bilayers

1988 • 70 citations

Inhibition of adenylate cyclase.

1985 • 65 citations

Isolation of homologous and heterologous complexes between catalytic and regulatory components of adenylate cyclase by forskolin—Speharose

1983 • 47 citations

The actions of hormones on the adenyl cyclase system.

1970 • 42 citations

Alteration in the protein components of catecholamine-sensitive adenylate cyclase during maturation of rat reticulocytes.

1981 • 41 citations

Electrophysiological characterization of cloned m1 muscarinic receptors expressed in A9 L cells.

1988 • 39 citations

Properties of beta-adrenergic receptors of cultured mammalian cells. Interaction of receptors with a guanine nucleotide-binding protein in membranes prepared from L6 myoblasts and from wild-type and cyc- S49 lymphoma cells.

1985 • 24 citations

Role of the β-Adrenergic Receptor in the Regulation of Adenylate Cyclase

1984 • 20 citations

Chapter 11 G Protein-Coupled Receptors: Structure and Function of Signal-Transducing Proteins

1990 • 9 citations

Interactions of β-adrenergic receptors with a membrane protein other than the stimulatory guanine nucleotide-binding protein

1987 • 9 citations

Molecular model of the G protein subunit based on the crystal structure of the HRAS protein

1989 • 4 citations

Deleted Work

1955 • 0 citations