Does Lithium Treatment Still Work?

One hundred years of schizophrenia: a meta-analysis of the outcome literature

1994 • 750 citations

PROPHYLACTIC LITHIUM: DOUBLE BLIND DISCONTINUATION IN MANIC-DEPRESSIVE AND RECURRENT-DEPRESSIVE DISORDERS

1970 • 500 citations

Rapid Cycling in Manic-Depressives Induced by Tricyclic Antidepressants

1979 • 405 citations

PROPHYLACTIC LITHIUM IN AFFECTIVE DISORDERS

1971 • 363 citations

Outcome in Manic Disorders

1990 • 357 citations

Lithium versus carbamazepine in the maintenance treatment of bipolar disorders – a randomised study

1997 • 260 citations

Relapse following discontinuation of lithium maintenance therapy in adolescents with bipolar I illness: a naturalistic study

1990 • 216 citations

Lithium Maintenance Treatment of Depression and Mania in Bipolar I and Bipolar II Disorders

1998 • 183 citations

Lithium Treatment and Risk of Suicidal Behavior in Bipolar Disorder Patients

1998 • 176 citations

A plea for integrity of the bipolar disorder concept

2000 • 164 citations

Multisite data reanalysis of the validity of rapid cycling as a course modifier for bipolar disorder in DSM-IV

1994 • 158 citations

Rapid cyclers, temperament, and antidepressants

1983 • 158 citations

Prophylactic Lithium: A Double-Blind Trial in Recurrent Affective Disorders

1970 • 156 citations

Does lithium reduce the mortality of recurrent mood disorders?

1991 • 152 citations

Effect of Lithium Maintenance on. Suicidal Behavior in Major Mood Disorders^a

1997 • 144 citations

A controlled evaluation of lithium prophylaxis in affective disorders

1972 • 143 citations

Discontinuing lithium maintenance treatment in bipolar disorders: risks and implications

1999 • 140 citations

Lithium Prophylaxis in Recurrent Affective Illness

1994 • 135 citations

PROPHYLACTIC LITHIUM IN RECURRENT AFFECTIVE DISORDERS

1972 • 133 citations

Does maintenance lithium therapy prevent recurrences of mania under ordinary clinical conditions?

1986 • 104 citations

Lithium Revisited

1995 • 95 citations

Effects of the Rate of Discontinuing Lithium Maintenance Treatment in Bipolar Disorders

1996 • 92 citations

Efficacy of Lithium Prophylaxis in Clinical Practice

1989 • 91 citations

RAPID RECURRENCE OF MANIA FOLLOWING ABRUPT DISCONTINUATION OF LITHIUM

1988 • 88 citations

Nonresponse to reinstituted lithium prophylaxis in previously responsive bipolar patients: prevalence and predictors

1995 • 74 citations

Current Therapeutic Profile of Lithium

1997 • 72 citations

Minimum Plasma Lithium Levels Required for Effective Prophylaxis in DSM III Bipolar Disorder: A Prospective Study

1986 • 65 citations

The long term prophylaxis of affective disorders.

1995 • 63 citations

Abrupt lithium discontinuation in manic‐depressive patients

1982 • 56 citations

Rapid recurrence of mania following lithium withdrawal.

1980 • 48 citations

Lithium Monotherapy: Miracle, Myth and Misunderstanding

1994 • 41 citations

Studies on the Course of Recurrent Endogenous Affective Disorders

1970 • 41 citations

Drug-Induced Switching in Bipolar Disorder

1997 • 40 citations

Lithium Withdrawal Triggers Psychosis

1982 • 37 citations

Experimental Withdrawal of Lithium in Recovered Manic-Depressive Patients: A Report of Five Cases

1971 • 37 citations

Recurrence of affective illness after withdrawal of long‐term lithium treatment

1983 • 31 citations

How Effective is Lithium in the Prevention of Relapse in Bipolar Disorder? A Prospective Naturalistic Follow-Up Study

1998 • 30 citations

The effectiveness of lithium prophylaxis in bipolar and unipolar depressions and schizo-affective disorders

1986 • 30 citations

Treatment of bipolar disorder: how far have we come?

1994 • 28 citations

Withdrawal Symptoms from Lithium

1983 • 23 citations

III. A DOUBLE BLIND STUDY OF THE PROPHYLACTIC EFFECT OF LITHIUM IN MANIC‐DEPRESSIVE DISEASE

1977 • 14 citations

Shifts in hospital diagnostic frequencies: bipolar disorder subtypes, 1981–1993

1997 • 10 citations

A pilot study of managed lithium discontinuation.

1988 • 9 citations

Lithium discontinuation in bipolar illness: a double-blind prospective controlled study

1984 • 8 citations