HC-Pro Suppression of Transgene Silencing Eliminates the Small RNAs but Not Transgene Methylation or the Mobile Signal

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

RNAi

2000 • 2,596 citations

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans.

1990 • 2,386 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

Epigenetics: Regulation Through Repression

1999 • 1,215 citations

Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression.

1990 • 1,182 citations

Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

1998 • 1,121 citations

Arabidopsis SGS2 and SGS3 Genes Are Required for Posttranscriptional Gene Silencing and Natural Virus Resistance

2000 • 1,082 citations

Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana

1998 • 1,073 citations

An RNA-Dependent RNA Polymerase Gene in Arabidopsis Is Required for Posttranscriptional Gene Silencing Mediated by a Transgene but Not by a Virus

2000 • 1,061 citations

Suppression of gene silencing: A general strategy used by diverse DNA and RNA viruses of plants

1999 • 1,038 citations

A viral suppressor of gene silencing in plants

1998 • 897 citations

A Counterdefensive Strategy of Plant Viruses

1998 • 815 citations

Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions

1997 • 777 citations

mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD

1999 • 745 citations

Systemic Spread of Sequence-Specific Transgene RNA Degradation in Plants Is Initiated by Localized Introduction of Ectopic Promoterless DNA

1998 • 694 citations

A Viral Movement Protein Prevents Spread of the Gene Silencing Signal in Nicotiana benthamiana

2000 • 677 citations

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

1999 • 653 citations

RNA-triggered gene silencing

1999 • 623 citations

AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals

2000 • 555 citations

EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans

2000 • 546 citations

Transgene‐induced gene silencing in plants

1998 • 490 citations

RNA–DNA Interactions and DNA Methylation in Post-Transcriptional Gene Silencing

1999 • 452 citations

Double-Stranded RNA as a Template for Gene Silencing

2000 • 421 citations

The interface of sigma with core RNA polymerase is extensive, conserved, and functionally specialized

1999 • 419 citations

Suppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes.

1996 • 375 citations

Listening to the silent genes: transgene silencing, gene regulation and pathogen control

1999 • 367 citations

Virus-encoded suppressor of posttranscriptional gene silencing targets a maintenance step in the silencing pathway

2000 • 363 citations

A Calmodulin-Related Protein That Suppresses Posttranscriptional Gene Silencing in Plants

2000 • 351 citations

Expression of single copies of a strongly expressed 35S transgene can be silenced post‐transcriptionally

1996 • 291 citations

Expression of a truncated tomato polygalacturonase gene inhibits expression of the endogenous gene in transgenic plants

1990 • 280 citations

Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase

1999 • 252 citations

Gene silencing in worms and fungi

2000 • 251 citations

Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression

1998 • 235 citations

Replication of potato virus X RNA is altered in coinfections with potato virus Y

1991 • 228 citations

An RNA-Based Information Superhighway in Plants

1998 • 225 citations

A model for RNA-mediated gene silencing in higher plants.

1998 • 213 citations

RNA-based silencing strategies in plants

2001 • 212 citations

5′ Proximal potyviral sequences mediate potato virus X/potyviral synergistic disease in transgenic tobacco

1995 • 196 citations

Heavy de novo methylation at symmetrical and non-symmetrical sites is a hallmark of RNA-directed DNA methylation

1999 • 178 citations

Infection of Tobacco orArabidopsisPlants by CMV Counteracts Systemic Post-transcriptional Silencing of Nonviral (Trans)Genes

1998 • 178 citations

Paramutation, an allelic interaction, is associated with a stable and heritable reduction of transcription of the maize b regulatory gene.

1993 • 155 citations

A Link Between RNA Interference and Nonsense-Mediated Decay in Caenorhabditis elegans

2000 • 145 citations

Mutations in the Region Encoding the Central Domain of Helper Component-Proteinase (HC-Pro) Eliminate Potato Virus X/Potyviral Synergism

1997 • 132 citations

Expression of potyviral polyproteins in transgenic plants reveals three proteolytic activities required for complete processing.

1990 • 129 citations

Transgenes are dispensable for the RNA degradation step of cosuppression

1998 • 120 citations

RNA viruses as inducers, suppressors and targets of post-transcriptional gene silencing.

2000 • 119 citations

RNA Interference

2000 • 101 citations

Dissecting the Mechanisms of Posttranscriptional Gene Silencing

1999 • 94 citations

A tobacco matrix attachment region reduces the loss of transgene expression in the progeny of transgenic tobacco plants

1999 • 74 citations

RNA silencing

2000 • 52 citations

Expression of lipid body protein gene during maize seed development. Spatial, temporal, and hormonal regulation.

1988 • 45 citations