AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals

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1998 • 14,674 citations

Multiple sequence alignment with hierarchical clustering

1988 • 5,250 citations

RNAi

2000 • 2,596 citations

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans.

1990 • 2,386 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

1998 • 1,121 citations

Arabidopsis SGS2 and SGS3 Genes Are Required for Posttranscriptional Gene Silencing and Natural Virus Resistance

2000 • 1,082 citations

Suppression of gene silencing: A general strategy used by diverse DNA and RNA viruses of plants

1999 • 1,038 citations

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

1990 • 962 citations

A viral suppressor of gene silencing in plants

1998 • 897 citations

Targeted mRNA degradation by double-stranded RNA in vitro

1999 • 845 citations

Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions

1997 • 777 citations

Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences

1992 • 773 citations

mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD

1999 • 745 citations

Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance.

1993 • 734 citations

Systemic Spread of Sequence-Specific Transgene RNA Degradation in Plants Is Initiated by Localized Introduction of Ectopic Promoterless DNA

1998 • 694 citations

AGO1 defines a novel locus of Arabidopsis controlling leaf development

1998 • 657 citations

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

1999 • 653 citations

Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana

2000 • 647 citations

RNA-triggered gene silencing

1999 • 623 citations

EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans

2000 • 546 citations

How and Why Do Plants Inactivate Homologous (Trans)genes?

1995 • 518 citations

Transgene‐induced gene silencing in plants

1998 • 490 citations

The PINHEAD/ZWILLE gene acts pleiotropically in Arabidopsis development and has overlapping functions with the ARGONAUTE1 gene

1999 • 469 citations

RNA–DNA Interactions and DNA Methylation in Post-Transcriptional Gene Silencing

1999 • 452 citations

Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes

2000 • 435 citations

Double-Stranded RNA as a Template for Gene Silencing

2000 • 421 citations

The interface of sigma with core RNA polymerase is extensive, conserved, and functionally specialized

1999 • 419 citations

Role of the ZWILLE gene in the regulation of central shoot meristem cell fate during Arabidopsis embryogenesis

1998 • 378 citations

Suppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes.

1996 • 375 citations

Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation.

1996 • 373 citations

Listening to the silent genes: transgene silencing, gene regulation and pathogen control

1999 • 367 citations

RNA interference: genetic wand and genetic watchdog

2000 • 309 citations

Isolation of quelling-defective ( qde ) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa

1997 • 307 citations

Posttranscriptional silencing of reporter transgenes in tobacco correlates with DNA methylation.

1994 • 284 citations

RNA as a target and an initiator of post-transcriptional gene silencing in trangenic plants

1996 • 284 citations

Induction of a Highly Specific Antiviral State in Transgenic Plants: Implications for Regulation of Gene Expression and Virus Resistance

1993 • 262 citations

Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase

1999 • 252 citations

Gene silencing in worms and fungi

2000 • 251 citations

RNAi and double-strand RNA

1999 • 242 citations

Post-transcriptional gene silencing in plants

1997 • 241 citations

Arabidopsis Mutants Impaired in Cosuppression

1998 • 238 citations

De novomethylation and co-suppression induced by a cytoplasmically replicating plant RNA virus

1998 • 195 citations

Infection of Tobacco orArabidopsisPlants by CMV Counteracts Systemic Post-transcriptional Silencing of Nonviral (Trans)Genes

1998 • 178 citations

A transgene with repeated DNA causes high frequency, post‐transcriptional suppression of ACC‐oxidase gene expression in tomato

1998 • 132 citations

Suppression of Virus Accumulation in Transgenic Plants Exhibiting Silencing of Nuclear Genes

1996 • 128 citations

Molecular cloning and characterization of a rabbit eIF2C protein

1998 • 69 citations

Conservation of transgene-induced post-transcriptional gene silencing in plants and fungi

1997 • 69 citations

Silencing of a beta-1,3-glucanase transgene is overcome during seed formation.

1997 • 29 citations

Renewing an old view of chloroplasts

1997 • 25 citations