RNA-based silencing strategies in plants

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

RNAi

2000 • 2,596 citations

Phytochromes and light signal perception by plants—an emerging synthesis

2000 • 1,351 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

1998 • 1,121 citations

Arabidopsis SGS2 and SGS3 Genes Are Required for Posttranscriptional Gene Silencing and Natural Virus Resistance

2000 • 1,082 citations

Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana

1998 • 1,073 citations

An RNA-Dependent RNA Polymerase Gene in Arabidopsis Is Required for Posttranscriptional Gene Silencing Mediated by a Transgene but Not by a Virus

2000 • 1,061 citations

Suppression of gene silencing: A general strategy used by diverse DNA and RNA viruses of plants

1999 • 1,038 citations

Total silencing by intron-spliced hairpin RNAs

2000 • 968 citations

RNA-directed de novo methylation of genomic sequences in plants

1994 • 929 citations

A viral suppressor of gene silencing in plants

1998 • 897 citations

Transcriptional silencing and promoter methylation triggered by double-stranded RNA

2000 • 866 citations

mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD

1999 • 745 citations

A Viral Movement Protein Prevents Spread of the Gene Silencing Signal in Nicotiana benthamiana

2000 • 677 citations

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

1999 • 653 citations

Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana

2000 • 647 citations

AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals

2000 • 555 citations

EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans

2000 • 546 citations

RNA–DNA Interactions and DNA Methylation in Post-Transcriptional Gene Silencing

1999 • 452 citations

Double-Stranded RNA as a Template for Gene Silencing

2000 • 421 citations

Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation.

1996 • 373 citations

Virus-encoded suppressor of posttranscriptional gene silencing targets a maintenance step in the silencing pathway

2000 • 363 citations

Post-transcriptional gene silencing across kingdoms

2000 • 353 citations

A Calmodulin-Related Protein That Suppresses Posttranscriptional Gene Silencing in Plants

2000 • 351 citations

Silencing of Retrotransposons in Arabidopsis and Reactivation by the ddm1 Mutation

2000 • 312 citations

HC-Pro Suppression of Transgene Silencing Eliminates the Small RNAs but Not Transgene Methylation or the Mobile Signal

2001 • 310 citations

RNA interference: genetic wand and genetic watchdog

2000 • 309 citations

(T<scp>RANS</scp>)G<scp>ENE</scp> S<scp>ILENCING IN</scp> P<scp>LANTS</scp>: How Many Mechanisms?

2000 • 304 citations

Transgene silencing by the host genome defense: implications for the evolution of epigenetic control mechanisms in plants and vertebrates.

2000 • 286 citations

RNA-directed DNA methylation.

2000 • 258 citations

Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase

1999 • 252 citations

Gene silencing in worms and fungi

2000 • 251 citations

A single copy of a virus‐derived transgene encoding hairpin RNA gives immunity to barley yellow dwarf virus

2000 • 247 citations

Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos

2000 • 239 citations

DNA methylation and chromatin structure affect transcriptional and post-transcriptional transgene silencing in Arabidopsis

2000 • 238 citations

Arabidopsis Mutants Impaired in Cosuppression

1998 • 238 citations

Suppression of post-transcriptional gene silencing by a plant viral protein localized in the nucleus

2000 • 232 citations

Production of aberrant promoter transcripts contributes to methylation and silencing of unlinked homologous promoters in trans

1999 • 228 citations

De novomethylation and co-suppression induced by a cytoplasmically replicating plant RNA virus

1998 • 195 citations

Potato Virus X Amplicons in Arabidopsis Mediate Genetic and Epigenetic Gene Silencing

2000 • 186 citations

Heavy de novo methylation at symmetrical and non-symmetrical sites is a hallmark of RNA-directed DNA methylation

1999 • 178 citations

High-efficiency silencing of a beta-glucuronidase gene in rice is correlated with repetitive transgene structure but is independent of DNA methylation.

2000 • 152 citations

A Link Between RNA Interference and Nonsense-Mediated Decay in Caenorhabditis elegans

2000 • 145 citations

A DNA target of 30 bp is sufficient for RNA-directed DNA methylation

2000 • 115 citations

The silence of the genes

2000 • 114 citations

Systemic silencing signal(s).

2000 • 95 citations

Distinct features of post‐transcriptional gene silencing by antisense transgenes in single copy and inverted T‐DNA repeat loci

2000 • 89 citations

Making noise about silence: repression of repeated genes in animals

2000 • 79 citations

Drug‐induced hypomethylation of a posttranscriptionally silenced transgene locus of tobacco leads to partial release of silencing

2000 • 59 citations

RNA silencing

2000 • 52 citations

Diversity of homology-dependent gene silencing strategies in fungi

2000 • 45 citations

Plant viral suppressors of post‐transcriptional silencing do not suppress transcriptional silencing

2000 • 37 citations

Cross‐talk between posttranscriptionally silenced neomycin phosphotransferase II transgenes

2000 • 29 citations

Both sense and antisense RNAs are targets for the sense transgene-induced posttranscriptional silencing mechanism

2000 • 28 citations

Developmentally and transgene regulated nuclear processing of primary transcripts of chalcone synthase A in petunia

2000 • 27 citations