RNAi

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Initiation of translation in prokaryotes and eukaryotes

1999 • 1,379 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

The Molecular Basis of Antibiotic Action

1981 • 1,237 citations

Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

1998 • 1,121 citations

Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway

1998 • 1,116 citations

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1995 • 1,099 citations

Targeted mRNA degradation by double-stranded RNA in vitro

1999 • 845 citations

mut-7 of C. elegans, Required for Transposon Silencing and RNA Interference, Is a Homolog of Werner Syndrome Helicase and RNaseD

1999 • 745 citations

Specific interference with gene function by double-stranded RNA in early mouse development

1999 • 719 citations

Double-stranded RNA induces mRNA degradation inTrypanosomabrucei

1998 • 705 citations

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

1999 • 653 citations

Fast forward genetics based on virus-induced gene silencing

1999 • 630 citations

RNA-triggered gene silencing

1999 • 623 citations

RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans

1998 • 561 citations

EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans

2000 • 546 citations

Double-stranded RNA specifically disrupts gene expression during planarian regeneration

1999 • 537 citations

Transgene‐induced gene silencing in plants

1998 • 490 citations

Translational control

1991 • 464 citations

Gene Silencing without DNA: RNA-Mediated Cross-Protection between Viruses

1999 • 444 citations

[3] Use of in Vitro32P labeling in the sequence analysis of nonradioactive tRNAs

1979 • 442 citations

The interface of sigma with core RNA polymerase is extensive, conserved, and functionally specialized

1999 • 419 citations

Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation.

1996 • 373 citations

Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonic somatic muscle formation

1999 • 332 citations

Isolation of quelling-defective ( qde ) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa

1997 • 307 citations

Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase

1999 • 252 citations

Isolation of an RNA-Directed RNA Polymerase–Specific cDNA Clone from Tomato

1998 • 251 citations

RNAi and double-strand RNA

1999 • 242 citations

Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression

1998 • 235 citations

2 The Pathway and Mechanism of Eukaryotic Protein Synthesis

1996 • 225 citations

Double–Stranded RNA Induces Specific Developmental Defects in Zebrafish Embryos

1999 • 205 citations

Silencing of Developmental Genes in Hydra

1999 • 204 citations

RNA editing and hypermutation by adenosine deamination

1997 • 186 citations

RNA-directed RNA polymerase from tomato leaves. II. Catalytic in vitro properties

1993 • 152 citations

Translational control of dosage compensation in Drosophila by Sex-lethal: cooperative silencing via the 5' and 3' UTRs of msl-2 mRNA is independent of the poly(A) tail

1999 • 128 citations

Activation of the Meiotic Divisions inDrosophilaOocytes

1997 • 122 citations

Mechanism, Specificity and General Properties of the Yeast Enzyme Catalysing the Formation of Inosine 34 in the Anticodon of Transfer RNA

1996 • 110 citations

RNA-directed RNA polymerase from tomato leaves. I. Purification and physical properties

1993 • 107 citations

Dissecting the Mechanisms of Posttranscriptional Gene Silencing

1999 • 94 citations

Enhancers of glp-1, a gene required for cell-signaling in Caenorhabditis elegans, define a set of genes required for germline development.

1995 • 86 citations

Genetics: A touch of elegance with RNAi

1999 • 75 citations

Isolation of an RNA-Directed RNA Polymerase-Specific cDNA Clone from Tomato

1998 • 55 citations

Gene silencing: Shrinking the black box of RNAi

2000 • 53 citations