Multiple Sclerosis as a By-Product of the Failure to Sustain Protective Autoimmunity: A Paradigm Shift

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis

2000 • 907 citations

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

1999 • 881 citations

Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats

1998 • 794 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis

2001 • 650 citations

Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy

2001 • 630 citations

Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: evidence of a hyper- and subsequent hypometabolic state

1991 • 571 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

Immunological Aspects of Experimental Allergic Encephalomyelitis and Multiple Sclerosis

1995 • 381 citations

Passive or Active Immunization with Myelin Basic Protein Promotes Recovery from Spinal Cord Contusion

2000 • 368 citations

Protective Autoimmunity Is a Physiological Response to CNS Trauma

2001 • 349 citations

Innate and adaptive immune responses can be beneficial for CNS repair

1999 • 336 citations

CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations

2000 • 334 citations

T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies

2000 • 312 citations

Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: Implications for glaucoma

2001 • 293 citations

Transplantation of activated macrophages overcomes central nervous system regrowth failure

1996 • 281 citations

HIV neuropathy: Insights in the pathology of HIV peripheral nerve disease

2001 • 247 citations

Diffuse prolonged depression of cerebral oxidative metabolism following concussive brain injury in the rat: a cytochrome oxidase histochemistry study

1991 • 241 citations

Neuronal Survival after CNS Insult Is Determined by a Genetically Encoded Autoimmune Response

2001 • 231 citations

The third function of the thymus

2000 • 213 citations

Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease

2001 • 205 citations

TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease

2000 • 186 citations

Calcium-dependent glutamate release concomitant with massive potassium flux during cerebral ischemia in vivo

1991 • 172 citations

Experimental neurobiology of central nervous system trauma.

1993 • 167 citations

Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries

2001 • 164 citations

Differential T cell response in central and peripheral nerve injury: connection with immune privilege

1999 • 157 citations

Intrathymic Expression of Genes Involved in Organ Specific Autoimmune Disease

1998 • 155 citations

Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment

2001 • 137 citations

Diffusion anisotropy MRI for quantitative assessment of recovery in injured rat spinal cord

2001 • 137 citations

Distribution of papovavirus, myelin‐associated glycoprotein, and myelin basic protein in progressive multifocal leukoencephalopathy lesions

1982 • 122 citations

Peripheral nerve‐stimulated macrophages simulate a peripheral nerve‐like regenerative response in rat transected optic nerve

1998 • 113 citations

Mechanisms of damage to myelin and oligodendrocytes and their relevance to disease

1999 • 110 citations

Immunological update on multiple sclerosis

2001 • 108 citations

Peripheral nerve-stimulated macrophages simulate a peripheral nerve-like regenerative response in rat transected optic nerve

1998 • 99 citations

The development of Cop 1 (Copaxone®), and innovative drug for the treatment of multiple sclerosis: personal reflections

1996 • 94 citations

Autoimmune T cells retard the loss of function in injured rat optic nerves

2000 • 93 citations

Potential Repair of Rat Spinal Cord Injuries Using Stimulated Homologous Macrophages

1999 • 90 citations

Neonatal Dexamethasone Treatment Increases Susceptibility to Experimental Autoimmune Disease in Adult Rats

2000 • 90 citations

Accumulation of passively transferred primed T cells independently of their antigen specificity following central nervous system trauma

1998 • 90 citations

Restricted inflammatory reaction in the CNS: a key impediment to axonal regeneration?

1998 • 76 citations

The remedy may lie in ourselves: prospects for immune cell therapy in central nervous system protection and repair

1999 • 72 citations

Control of Autoimmunity by Regulatory T Cells

2001 • 70 citations

Myelin protein expression in lymphoid tissues: implications for peripheral tolerance

1998 • 64 citations

High-dose methylprednisolone may do more harm for spinal cord injury

2000 • 61 citations

Relationship between extracellular neurotransmitter amino acids and energy metabolism during cerebral ischemia in rats monitored by microdialysis and in vivo magnetic resonance spectroscopy

1993 • 59 citations

Renal Diseases Associated with Human Immunodeficiency Virus Infection: Epidemiology, Clinical Course, and Management

2001 • 59 citations

Comparison of Single and Combination Drug Treatment Strategies in Experimental Brain Trauma

1993 • 58 citations

Axonal damage induced by cerebrospinal fluid from patients with relapsing-remitting multiple sclerosis

2000 • 56 citations

Increased post-traumatic survival of neurons in IL-6-knockout mice on a background of EAE susceptibility

2001 • 56 citations

Immune‐related mechanisms participating in resistance and susceptibility to glutamate toxicity

2002 • 52 citations

Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse

1995 • 48 citations

Multiple Sclerosis and Central Nervous System Demyelination

1999 • 44 citations

Mast cells and multiple sclerosis: a quantitative analysis

2001 • 44 citations

Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance

2001 • 38 citations

A Common Immunoregulatory Locus Controls Susceptibility to Actively Induced Experimental Allergic Encephalomyelitis and Experimental Allergic Orchitis in BALB/c Mice

1998 • 37 citations

Bcl‐2 expressing T lymphocytes in multiple sclerosis lesions

1998 • 34 citations

GM1 reduces injury-induced metabolic deficits and degeneration in the rat optic nerve.

1992 • 32 citations

Dynamics of serum IgM autoreactive repertoires following immunization: strain specificity, inheritance and association with autoimmune disease susceptibility

1998 • 28 citations

Link between optic nerve regrowth failure and macrophage stimulation in mammals

1999 • 26 citations

The pathogenesis of multiple sclerosis: a commentary

2000 • 25 citations

Mechanisms of tissue injury in multiple sclerosis: opportunities for neuroprotective therapy

2000 • 25 citations

Depletion of T Lymphocytes with Immunotoxin Retards the Progress of Experimental Allergic Encephalomyelitis in Rhesus Monkeys

1997 • 22 citations

Severe Immunodeficiency Has Opposite Effects on Neuronal Survival in Glutamate-Susceptible and -Resistant Mice: Adverse Effect of B Cells

2002 • 20 citations

T-cell-mediated control of autoimmunity.

2001 • 14 citations

Skin Diseases Associated with HIV Infection

2001 • 2 citations

Plaques, T cells and beyond: report on an international meeting on the immunological basis of multiple sclerosis held at the University of Chieti, Italy

1999 • 2 citations