Control of Autoimmunity by Regulatory T Cells

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.

1985 • 721 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

1969 • 554 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

α/β–T Cell Receptor (TCR)+CD4−CD8− (NKT) Thymocytes Prevent Insulin-dependent Diabetes Mellitus in Nonobese Diabetic (NOD)/Lt Mice by the Influence of Interleukin (IL)-4 and/or IL-10

1998 • 473 citations

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

1998 • 447 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis

1998 • 299 citations

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity

1999 • 284 citations

T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice.

1989 • 257 citations

Organ‐specific Autoimmunity Induced by Lymphopenia

1996 • 194 citations

T Cell-Mediated Maintenance of Natural Self-Tolerance: its Breakdown as a Possible Cause of Various Autoimmune Diseases

1996 • 175 citations

Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase- reactive T cells

1999 • 129 citations

Self‐Ignorance in the Peripheral T‐Cell Pool

1993 • 124 citations

The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: the Function of the Thymus in the Generation of the Regulatory T Cell Subset

1996 • 121 citations

Thyroiditis in T cell-depleted rats. Influence of strain, radiation dose, adjuvants and antilymphocyte serum.

1975 • 118 citations

Immunologic and clinical studies on murine experimental autoimmune gastritis induced by neonatal thymectomy

1988 • 113 citations

Pathogenesis of post-thymectomy autoimmune gastritis. Identification of anti-H/K adenosine triphosphatase-reactive T cells.

1996 • 92 citations

Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression.

1994 • 65 citations

Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice

1998 • 36 citations

Induction of Diabetes in PVG/c Strain Rats by Manipulation of the Immune System

1990 • 28 citations