Mechanisms of tissue injury in multiple sclerosis: opportunities for neuroprotective therapy

Caspases: Enemies Within

1998 • 6,923 citations

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis

1996 • 741 citations

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

1997 • 558 citations

Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.

1998 • 514 citations

Axonal damage correlates with disability in patients with relapsing- remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study

1998 • 499 citations

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

1996 • 362 citations

Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain.

1996 • 283 citations

Immunopathology of multiple sclerosis: Report on an international meeting held at the Institute of Neurology of the University of Vienna

1998 • 240 citations

Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury

1995 • 180 citations

TNF-α transgenic and knockout models of CNS inflammation and degeneration

1997 • 164 citations

MHC Class I-Restricted Lysis of Human Oligodendrocytes by Myelin Basic Protein Peptide-Specific CD8 T Lymphocytes

1998 • 162 citations

Increased severity of experimental autoimmune encephalomyelitis, chronic macrophage/microglial reactivity, and demyelination in transgenic mice producing tumor necrosis factor‐α in the central nervous system

1997 • 142 citations

The Norton Lecture: a review of the oligodendrocyte in the multiple sclerosis lesion1Presented at the Albert Einstein College of Medicine, Bronx, NY, on February 3, 1997 in honor of the retirement of Dr. William T. Norton, a pioneer neurochemist in the myelin/oligodendrocyte arena.1

1997 • 140 citations

Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis

1997 • 137 citations

p75 Neurotrophin Receptor Expression on Adult Human Oligodendrocytes: Signaling without Cell Death in Response to NGF

1998 • 126 citations

Interferon-γ Modulates Human Oligodendrocyte Susceptibility To Fas-Mediated Apoptosis

2000 • 111 citations

Ciliary neurotrophic factor selectively protects human oligodendrocytes from tumor necrosis factor-mediated injury

1996 • 95 citations

Fas expression on human fetal astrocytes without susceptibility to fas-mediated cytotoxicity

1998 • 79 citations

Expression of Tumor Necrosis Factor α (TNFα) and Interleukin 6 (IL-6) mRNA in Adult Human Astrocytes

1996 • 75 citations

Culture of Glial Cells from Human Brain Biopsies

1997 • 70 citations

Astrocytes and catalase prevent the toxicity of catecholamines to oligodendrocytes

1994 • 69 citations

A novel population of CD4+CD56+ myelin-reactive T cells lyses target cells expressing CD56/neural cell adhesion molecule.

1996 • 64 citations

Mechanism of γδ T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosis

1998 • 58 citations

Non-MHC-Restricted Cell-Mediated Lysis of Human Oligodendrocytes In Vitro: Relation with CD56 Expression

1998 • 58 citations

Oligodendrocyte lysis by CD4⁺ T cells independent of tumor necrosis factor

1994 • 57 citations

p53 Induction by Tumor Necrosis Factor‐α and Involvement of p53 in Cell Death of Human Oligodendrocytes

1999 • 55 citations