Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

2000 • 3,258 citations

Axonal damage in acute multiple sclerosis lesions

1997 • 1,543 citations

Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?

1999 • 1,011 citations

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

1999 • 999 citations

Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

2000 • 918 citations

Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis

2000 • 907 citations

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

1999 • 881 citations

McAlpine's Multiple Sclerosis

2006 • 768 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

Monocyte/macrophage differentiation in early multiple sclerosis lesions

1995 • 513 citations

A quantitative analysis of oligodendrocytes in multiple sclerosis lesions

1999 • 445 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives

1997 • 365 citations

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

1996 • 362 citations

Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study

1999 • 345 citations

The neuropathology of multiple sclerosis.

2000 • 332 citations

Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis

1983 • 287 citations

Axonal Pathology in Multiple Sclerosis. A Historical Note

1999 • 193 citations

TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease

2000 • 186 citations

Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS

1998 • 179 citations

Mechanism of Calcium Entry during Axon Injury and Degeneration

1997 • 161 citations

Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein

1999 • 152 citations

Oligodendroglial precursor cell susceptibility to hypoxia is related to poor ability to cope with reactive oxygen species

1995 • 123 citations

Distribution of papovavirus, myelin‐associated glycoprotein, and myelin basic protein in progressive multifocal leukoencephalopathy lesions

1982 • 122 citations

Proinflammatory and Antiinflammatory Cytokines in Multiple Sclerosis and Central Nervous System Acquired Immunodeficiency Syndrome

1992 • 120 citations

Evidence for a “dying‐back” gliopathy in demyelinating disease

1981 • 113 citations

Selective Degeneration of Oligodendrocytes Mediated by Reactive Oxygen Species

1990 • 104 citations

Macrophages in CNS remyelination: friend or foe?

1998 • 78 citations

Virus-Induced Demyelination in Mice: “Dying Back” of Oligodendrocytes

1985 • 70 citations

The genetics of multiple sclerosis. A review

1999 • 70 citations

Multiple sclerosis

1980 • 55 citations

Temporary Axonal Conduction Block and Axonal Loss in Inflammatory Neurological Disease: A Potential Role for Nitric Oxide?

1999 • 40 citations

Bacterial vaccines for the treatment of multiple sclerosis and other autoimmune diseases

2000 • 31 citations

Magnetisation transfer imaging in multiple sclerosis.

2000 • 22 citations