Myelin protein expression in lymphoid tissues: implications for peripheral tolerance

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

Experimental Autoimmune Encephalomyelitis Induction in Genetically B Cell–deficient Mice

1996 • 665 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype

1989 • 390 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.

1993 • 277 citations

A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease.

1996 • 270 citations

Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.

1994 • 237 citations

CD40 and Its Ligand in Host Defense

1996 • 236 citations

Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression.

1995 • 222 citations

Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain.

1993 • 218 citations

The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems.

1993 • 194 citations

A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.

1991 • 165 citations

Effector T lymphocyte line cells migrate to the thymus and persist there

1982 • 165 citations

Diversity and plasticity of self recognition during the development of multiple sclerosis.

1997 • 164 citations

The Role of B7-1/B7-2:CD28/CLTA-4 Pathways in the Prevention of Anergy, Induction of Productive Immunity and Down-Regulation of the Immune Response

1996 • 161 citations

Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells.

1995 • 150 citations

T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE). Functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells

1983 • 145 citations

A T Helper Cell 2 (Th2) Immune Response against Non-self Antigens Modifies the Cytokine Profile of Autoimmune T Cells and Protects against Experimental Allergic Encephalomyelitis

1997 • 136 citations

Requirement for CD8⁺Cells in T Cell Receptor Peptide-Induced Clonal Unresponsiveness

1993 • 122 citations

Activation requirements for CD4+ T cells differing in CD45R expression.

1992 • 107 citations

Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo.

1993 • 104 citations

Antigen-specific therapy of experimental allergic encephalomyelitis by soluble class II major histocompatibility complex-peptide complexes.

1991 • 103 citations

The major myelin protein genes are expressed in the human thymus

1996 • 100 citations

Development of Reactivity to New Myelin Antigens during Chronic Relapsing Autoimmune Demyelination

1993 • 98 citations

Ia expression in chronic relapsing experimental allergic encephalomyelitis induced by long-term cultured T cell lines in mice.

1986 • 78 citations

T cell co-stimulation and in vivo tolerance

1993 • 77 citations

The Shaping of the Brain–Specific T Lymphocyte Repertoire in the Thymus

1996 • 66 citations

Protective influences on experimental autoimmune encephalomyelitis by MHC class I and class II alleles.

1994 • 62 citations

Thymic expression of myelin basic protein (MBP). Activation of MBP-specific T cells by thymic cells in the absence of exogenous MBP.

1996 • 59 citations

Expression of the myelin proteolipid protein gene in the human fetal thymus

1996 • 59 citations

A New Family of Transcripts of the Myelin Basic Protein Gene: Expression in Brain and in Immune System

1993 • 57 citations

Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse

1995 • 48 citations

Myelin protein expression is increased in lymph nodes of mice with relapsing experimental autoimmune encephalomyelitis.

1997 • 45 citations

Adoptive transfer of murine chronic-relapsing autoimmune encephalomyelitis

1987 • 44 citations

A Novel Transcript Overlapping the Myelin Basic Protein Gene

1992 • 43 citations

Expression of a Novel Transcript of the Myelin Basic Protein Gene

1990 • 43 citations

Epitope spreading occurs in active but not passive EAE induced by myelin basic protein

1996 • 30 citations

Treatment of chronic relapsing experimental allergic encephalomyelitis with the intravenous administration of splenocytes coupled to encephalitogenic peptide 91–103 of myelin basic protein

1991 • 29 citations

The use of monoclonal antibodies for treatment of autoimmune disease

1990 • 27 citations

CD40 and Its Ligand in Autoimmimity

1997 • 22 citations

Reinduction of Experimental Autoimmune Encephalomyelitis in Mice

1995 • 20 citations

Myelin Basic Protein‐Related Proteins in Mouse Brain and Immune Tissues

1998 • 17 citations

Frequency of MBP and MBP peptide‐reactive T cells in the HPRT mutant T‐cell population of MS patients

1996 • 16 citations

Human T lymphocytes specific for the immunodominant 83-99 epitope of myelin basic protein: Recognition of golli MBP HOG 7

1996 • 16 citations

Identification of new human myelin basic protein transcripts in the immune and central nervous systems

1994 • 13 citations

Strain-related differences in the ability of T lymphocytes to recognize proteins encoded by the golli-myelin basic protein gene

1996 • 13 citations

Macrophages express glial markers

1988 • 11 citations