The role of GSK3 in glucose homeostasis and the development of insulin resistance

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

2005 • 2,161 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

Inhibition of Adipogenesis by Wnt Signaling

2000 • 1,822 citations

The glamour and gloom of glycogen synthase kinase-3

2004 • 1,490 citations

The multifaceted roles of glycogen synthase kinase 3β in cellular signaling

2001 • 1,408 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

2000 • 1,365 citations

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

2001 • 1,351 citations

Molecular cloning and expression of glycogen synthase kinase-3/factor A.

1990 • 1,329 citations

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

2000 • 1,253 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

1990 • 1,226 citations

GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

2003 • 1,145 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

2004 • 979 citations

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

2000 • 867 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

1992 • 709 citations

A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation

2001 • 679 citations

Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

1999 • 666 citations

Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation.

1993 • 616 citations

Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation

1994 • 578 citations

New aspects of Wnt signaling pathways in higher vertebrates

2001 • 550 citations

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation

2000 • 529 citations

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

1999 • 521 citations

Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo

2003 • 498 citations

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

1994 • 476 citations

Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling

2000 • 418 citations

Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1

1999 • 409 citations

Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects.

1984 • 407 citations

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

1993 • 399 citations

Glycogen synthase kinase 3: an emerging therapeutic target

2002 • 399 citations

Glycogen Synthase Kinase-3β Is a Negative Regulator of Cardiomyocyte Hypertrophy

2000 • 390 citations

Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1

1996 • 381 citations

Regulation and localization of tyrosine²¹⁶phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration

2000 • 359 citations

Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3.

1987 • 357 citations

31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.

1992 • 324 citations

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1997 • 316 citations

Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus.

1995 • 316 citations

Judging a Protein by More Than Its Name: GSK-3

2001 • 281 citations

Biochemical interactions in the wnt pathway

2000 • 265 citations

Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

1999 • 251 citations

Role of glycogen synthase kinase-3 in TNF-α-induced NF-κB activation and apoptosis in hepatocytes

2002 • 229 citations

The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle.

1996 • 226 citations

Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo.

1994 • 224 citations

Wnt Signaling to β-Catenin Involves Two Interactive Components

2000 • 220 citations

Effects of a Novel Glycogen Synthase Kinase-3 Inhibitor on Insulin-Stimulated Glucose Metabolism in Zucker Diabetic Fatty (fa/fa) Rats

2002 • 218 citations

Control of glycogen deposition

2003 • 215 citations

Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

2001 • 215 citations

Multisite phosphorylation of glycogen synthase

1984 • 208 citations

The Role of Glycogen Synthase Kinase 3β in Insulin-stimulated Glucose Metabolism

1999 • 204 citations

Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch

1993 • 203 citations

Inhibition of Glycogen Synthase Kinase 3 Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle

2002 • 191 citations

Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

1999 • 190 citations

Phosphorylation of the Type‐II Regulatory Subunit of Cyclic‐AMP‐Dependent Protein Kinase by Glycogen Synthase Kinase 3 and Glycogen Synthase Kinase 5

1982 • 184 citations

Phosphorylation of C/EBPβ at a Consensus Extracellular Signal-Regulated Kinase/Glycogen Synthase Kinase 3 Site Is Required for the Induction of Adiponectin Gene Expression during the Differentiation of Mouse Fibroblasts into Adipocytes

2004 • 179 citations

Serine 332 Phosphorylation of Insulin Receptor Substrate-1 by Glycogen Synthase Kinase-3 Attenuates Insulin Signaling

2004 • 170 citations

Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification

2000 • 162 citations

Insulin Control of Glycogen Metabolism in Knockout Mice Lacking the Muscle-Specific Protein Phosphatase PP1G/R_GL

2001 • 154 citations

Glycogen Synthase Kinase 3β Negatively Regulates Both DNA-binding and Transcriptional Activities of Heat Shock Factor 1

2000 • 154 citations

Conditional Protein Alleles Using Knockin Mice and a Chemical Inducer of Dimerization

2003 • 131 citations

[48] cDNA cloning and properties of glycogen synthase kinase-3

1991 • 131 citations

Regulation of Glycogen Synthase Kinase 3β and Downstream Wnt Signaling by Axin

1999 • 122 citations

Regulation of Glycogen Synthesis by Amino Acids in Cultured Human Muscle Cells

2001 • 117 citations

Identification of multifunctional ATP-citrate lyase kinase as the α-isoform of glycogen synthase kinase-3

1992 • 113 citations

Glucose Storage Is a Major Determinant of in Vivo “Insulin Resistance” in Subjects with Normal Glucose Tolerance

1986 • 113 citations

Inhibition of Glycogen-synthase Kinase 3 Stimulates Glycogen Synthase and Glucose Transport by Distinct Mechanisms in 3T3-L1 Adipocytes

2000 • 109 citations

Regulatory Role of Glycogen Synthase Kinase 3 for Transcriptional Activity of ADD1/SREBP1c

2004 • 106 citations

Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3‐kinase

1997 • 101 citations

PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance

2003 • 96 citations

Phosphoserine as a recognition determinant for glycogen synthase kinase-3: Phosphorylation of a synthetic peptide based on the G-component of protein phosphatase-1

1988 • 95 citations

Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects.

1998 • 94 citations

Positive and Negative Regulatory Role of Insulin Receptor Substrate 1 and 2 (IRS-1 and IRS-2) Serine/Threonine Phosphorylation

2002 • 93 citations

Regulation of the Protein Kinase Activity of ShaggyZeste-white3 by Components of the Wingless Pathway in Drosophila Cells and Embryos

1999 • 88 citations

Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen

2000 • 82 citations

Missing Links in GSK3 Regulation

2001 • 59 citations

Normalization of Insulin Sensitivity With Lithium in Diabetic Rats

1989 • 55 citations

Schizosaccharomyces pombe skp1⁺ Encodes a Protein Kinase Related to Mammalian Glycogen Synthase Kinase 3 and Complements a cdc14 Cytokinesis Mutant

1996 • 54 citations

Effect of glycogen synthase overexpression on insulin-stimulated muscle glucose uptake and storage

2004 • 51 citations

Glycogen Synthase Kinase 3β Is a Negative Regulator of Growth Factor-induced Activation of the c-Jun N-terminal Kinase

2004 • 47 citations

Judging a Protein by More Than Its Name: GSK-3

2001 • 43 citations

ATP citrate-lyase and glycogen synthase kinase-3β in 3T3-L1 cells during differentiation into adipocytes

1994 • 36 citations

Targets for Signal-transducing Protein Kinases

1988 • 32 citations

Antidiabetic effects of lithium.

1982 • 25 citations

Normalization of insulin sensitivity with lithium in diabetic rats

1989 • 19 citations