Wnt Signaling to β-Catenin Involves Two Interactive Components

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Molecular cloning and expression of glycogen synthase kinase-3/factor A.

1990 • 1,329 citations

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

1996 • 1,299 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Neural and developmental actions of lithium: A unifying hypothesis

1989 • 1,005 citations

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1998 • 998 citations

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1993 • 997 citations

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro

1999 • 914 citations

Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase.

1980 • 896 citations

Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling

1993 • 877 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

Cadherin-catenin complex: Protein interactions and their implications for cadherin function

1996 • 806 citations

Glycogen Synthase Kinase‐3 from Rabbit Skeletal Muscle

1980 • 750 citations

Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin

1997 • 702 citations

The oncogenic activation of β-catenin

1999 • 655 citations

The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

1999 • 650 citations

Activation of the Wnt Signaling Pathway: A Molecular Mechanism for Lithium Action

1997 • 627 citations

A common human skin tumour is caused by activating mutations in β-catenin

1999 • 608 citations

Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation

1994 • 578 citations

Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.

1995 • 545 citations

Regulation of LEF-1/TCF transcription factors by Wnt and other signals

1999 • 537 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

1995 • 492 citations

Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

1998 • 489 citations

β-Catenin mutations in cell lines established from human colorectal cancers

1997 • 483 citations

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

1994 • 476 citations

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in aG-protein-dependent manner

1999 • 476 citations

The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin

1999 • 432 citations

wingless signaling acts through zeste-white 3, the drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate

1992 • 425 citations

wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo

1994 • 423 citations

Transformation by Wnt family proteins correlates with regulation of beta-catenin.

1997 • 412 citations

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

1993 • 399 citations

Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

1996 • 396 citations

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

1998 • 395 citations

Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.

1992 • 394 citations

Wnt-1 Regulates Free Pools of Catenins and Stabilizes APC-Catenin Complexes

1996 • 337 citations

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

1995 • 321 citations

Signal transduction from multiple Ras effectors

1997 • 308 citations

Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription

1998 • 302 citations

Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level

1998 • 294 citations

PDK1, one of the missing links in insulin signal transduction?¹

1997 • 246 citations

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

1995 • 233 citations

Further evidence that the inhibition of glycogen synthase kinase‐3β by IGF‐1 is mediated by PDK1/PKB‐induced phosphorylation of Ser‐9 and not by dephosphorylation of Tyr‐216

1997 • 232 citations

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways

1997 • 223 citations

Glycogen synthase kinase 3 regulates cell fate in dictyostelium

1995 • 221 citations

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1994 • 204 citations

Deletion of an Amino-Terminal Sequence Stabilizes β-Catenin In Vivo and Promotes Hyperphosphorylation of the Adenomatous Polyposis Coli Tumor Suppressor Protein

1996 • 186 citations

Overexpression of Protein Kinase C βII Induces Colonic Hyperproliferation and Increased Sensitivity to Colon Carcinogenesis

1999 • 182 citations

Separation and Characterisation of Glycogen Synthase Kinase 3,Glycogen Synthase Kinase 4 and Glycogen Synthase Kinase 5 from Rabbit Skeletal Muscle

1982 • 175 citations

The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31‐8220) are potent inhibitors of glycogen synthase kinase‐3 activity

1999 • 140 citations

The Mouse Wnt-1 Gene Can Act Via a Paracrine Mechanism in Transformation of Mammary Epithelial Cells

1992 • 138 citations

Ras‐related proteins in signal transduction and growth control

1995 • 115 citations

The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells.

1992 • 109 citations

Regulation and functions of the glycogen synthase kinase-3 subfamily.

1994 • 103 citations

Identification of the phosphorylated region responsible for the permissive activation of protein kinase C

1993 • 88 citations

A Soluble Form of Wnt-1 Protein with Mitogenic Activity on Mammary Epithelial Cells

1995 • 83 citations

Inhibition of glycogen synthase kinase 3β activity regulates proliferation of cultured cerebellar granule cells

1998 • 71 citations

?Insulin-like? effects of lithium ion on isolated rat adipocytes II. Specific activation of glycogen synthase

1983 • 49 citations

The legacy of lithium effects on development

1998 • 35 citations

Lithium respecifiescyclic ‐AMP‐lnduced cell‐type specific gene expression in Dictyostelium

1988 • 34 citations

Grafting of triggering site onto lymphocytes; distribution of grafted dinitrophenyl groups on cell surface glycoproteins and glycolipids

1983 • 14 citations