The glamour and gloom of glycogen synthase kinase-3

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

The multifaceted roles of glycogen synthase kinase 3β in cellular signaling

2001 • 1,408 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

2000 • 1,365 citations

GSK3 takes centre stage more than 20 years after its discovery

2001 • 1,298 citations

GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

2003 • 1,145 citations

Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

1998 • 1,049 citations

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

2000 • 867 citations

Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity

2003 • 823 citations

A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation

2001 • 679 citations

Crystal Structure of Glycogen Synthase Kinase 3β

2001 • 636 citations

Molecular Targets of Lithium Action

2001 • 507 citations

Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo

2003 • 498 citations

Glycogen Synthase Kinase-3β

2002 • 435 citations

Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility

2002 • 404 citations

Glycogen synthase kinase 3: an emerging therapeutic target

2002 • 399 citations

Proteolysis of the Hedgehog Signaling Effector Cubitus interruptus Requires Phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1

2002 • 381 citations

Anti-bipolar therapy: mechanism of action of lithium

1999 • 372 citations

Synthetic small molecules that control stem cell fate

2003 • 365 citations

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

2001 • 361 citations

Spatial learning deficit in transgenic mice that conditionally over‐express GSK‐3β in the brain but do not form tau filaments

2002 • 360 citations

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

2000 • 344 citations

Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation

2002 • 328 citations

Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3‐kinase activation

2003 • 324 citations

Glycogen Synthase Kinase-3β Phosphorylates Protein Tau and Rescues the Axonopathy in the Central Nervous System of Human Four-repeat Tau Transgenic Mice

2000 • 313 citations

A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma–associated herpesvirus latency

2003 • 307 citations

Inhibition of GSK-3β leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium

1998 • 307 citations

Glycogen Synthase Kinase-3β Facilitates Staurosporine- and Heat Shock-induced Apoptosis

2000 • 305 citations

Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport

2003 • 300 citations

Identification of a link between the tumour suppressor APC and the kinesin superfamily

2002 • 300 citations

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

2002 • 294 citations

Direct, activating interaction between glycogen synthase kinase-3β and p53 after DNA damage

2002 • 258 citations

Central Role of Glycogen Synthase Kinase-3β in Endoplasmic Reticulum Stress-induced Caspase-3 Activation

2002 • 258 citations

Glycogen Synthase Kinase-3β (GSK3β) Binds to and Promotes the Actions of p53

2003 • 253 citations

Neuroprotective effects of lithium in cultured cells and animal models of diseases

2002 • 249 citations

An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling

2002 • 246 citations

Glycogen Synthase Kinase 3β Phosphorylates Tau at Both Primed and Unprimed Sites

2002 • 243 citations

Inhibition of protein kinase B/Akt

2002 • 241 citations

Glycogen synthase kinase‐3β, mood stabilizers, and neuroprotection

2002 • 241 citations

Role of glycogen synthase kinase-3 in TNF-α-induced NF-κB activation and apoptosis in hepatocytes

2002 • 229 citations

Stabilization of β-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth

2003 • 220 citations

Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

2001 • 215 citations

Proapoptotic Stimuli Induce Nuclear Accumulation of Glycogen Synthase Kinase-3β

2001 • 209 citations

Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3β

2002 • 203 citations

Glycogen synthase kinase-3β is highly activated in nuclei and mitochondria

2003 • 193 citations

Inhibition of Glycogen Synthase Kinase 3 Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle

2002 • 191 citations

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.

1999 • 189 citations

Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration

2002 • 188 citations

Glycogen Synthase Kinase-3β Inhibitors Prevent Cellular Polyglutamine Toxicity Caused by the Huntington’s Disease Mutation

2002 • 187 citations

The active form of glycogen synthase kinase-3? is associated with granulovacuolar degeneration in neurons in Alzheimer's disease

2002 • 171 citations

Valproate Regulates GSK-3-Mediated Axonal Remodeling and Synapsin I Clustering in Developing Neurons

2002 • 166 citations

Role of Translation Initiation Factor 2B in Control of Cell Survival by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Signaling Pathway

2002 • 164 citations

Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100

2002 • 163 citations

Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling Pathway

1999 • 156 citations

Glycogen Synthase Kinase-3β Regulates NF-κB1/p105 Stability

2003 • 156 citations

Role of glycogen synthase kinase-3 in cancer: Regulation by Wnts and other signaling pathways

2002 • 144 citations

A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment

2003 • 143 citations

Lithium Blocks the c-Jun Stress Response and Protects Neurons via Its Action on Glycogen Synthase Kinase 3

2003 • 143 citations

Insulin Mimetic Action of Synthetic Phosphorylated Peptide Inhibitors of Glycogen Synthase Kinase-3

2003 • 142 citations

Enhanced Glycogen Synthase Kinase-3β Activity Mediates Hypoxia-induced Apoptosis of Vascular Smooth Muscle Cells and Is Prevented by Glucose Transport and Metabolism

2002 • 138 citations

GSK-3 and the neurodevelopmental hypothesis of schizophrenia

2002 • 125 citations

A-Kinase Anchoring Protein AKAP220 Binds to Glycogen Synthase Kinase-3β (GSK-3β) and Mediates Protein Kinase A-dependent Inhibition of GSK-3β

2002 • 125 citations

Regulation of Angiogenesis by Glycogen Synthase Kinase-3β

2002 • 120 citations

Modulation of muscle insulin resistance by selective inhibition of GSK-3 in Zucker diabetic fatty rats

2003 • 108 citations

Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3

2003 • 102 citations

The Regulation of Glycogen Synthase Kinase-3 Nuclear Export by Frat/GBP

2002 • 89 citations

Glycogen Synthase Kinase 3β Is a Natural Activator of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase Kinase 1 (MEKK1)

2003 • 81 citations

Regulation of neuronal cytoskeleton by lysophosphatidic acid: role of GSK-3

2002 • 80 citations

Tau, where are we now?

2002 • 76 citations

Use of lithium and SB‐415286 to explore the role of glycogen synthase kinase‐3 in the regulation of glucose transport and glycogen synthase

2003 • 61 citations

Lithium Sensitizes Tumor Cells in an NF-κB-independent Way to Caspase Activation and Apoptosis Induced by Tumor Necrosis Factor (TNF)

2001 • 37 citations

Presenilin 1 Regulates β-Catenin-mediated Transcription in a Glycogen Synthase Kinase-3-independent Fashion

2001 • 35 citations

Deleted Work

1955 • 0 citations