The Role of Glycogen Synthase Kinase 3β in Insulin-stimulated Glucose Metabolism

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

1996 • 1,299 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

1998 • 1,049 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Chapter 8 Use of Recombinant Adenovirus for Metabolic Engineering of Mammalian Cells

1994 • 571 citations

Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin

1995 • 395 citations

Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

1998 • 369 citations

Essential Role for Protein Kinase B (PKB) in Insulin-induced Glycogen Synthase Kinase 3 Inactivation

1998 • 365 citations

Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport

1998 • 336 citations

Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt

1998 • 318 citations

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1997 • 316 citations

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase‐3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

1998 • 298 citations

New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

1997 • 293 citations

Glycogen Synthase from Rabbit Skeletal Muscle; Effect of Insulin on the State of phosphorylation of the Seven Phosphoserine Residues in vivo

1983 • 292 citations

Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 Kinase

1993 • 277 citations

Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes*

1997 • 252 citations

Regulation of Protein Kinase B and Glycogen Synthase Kinase-3 by Insulin and β-Adrenergic Agonists in Rat Epididymal Fat Cells

1997 • 241 citations

4PS/Insulin Receptor Substrate (IRS)-2 Is the Alternative Substrate of the Insulin Receptor in IRS-1-deficient Mice

1995 • 231 citations

Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue

1997 • 217 citations

Glycogen synthase: A new activity ratio assay expressing a high sensitivity to the phosphorylation state

1979 • 176 citations

Activation of Mitogen-activated Protein Kinase and Phosphatidylinositol 3′-Kinase Is Not Sufficient for the Hormonal Stimulation of Glucose Uptake, Lipogenesis, or Glycogen Synthesis in 3T3-L1 Adipocytes

1995 • 148 citations

Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells.

1996 • 135 citations

The Insulin-Sensitive Glucose Transporter

1992 • 135 citations

The Activation of Glycogen Synthase by Insulin Switches from Kinase Inhibition to Phosphatase Activation during Adipogenesis in 3T3-L1 Cells

1998 • 124 citations

The relationship between the transport of glucose and cations across cell membranes in isolated tissues IV. The ‘insulin-like’ effect of Li+

1968 • 115 citations

Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1993 • 98 citations

Insulin action in cultured human myoblasts: contribution of different signalling pathways to regulation of glycogen synthesis

1996 • 91 citations

Platelet-derived Growth Factor Inhibits Insulin Stimulation of Insulin Receptor Substrate-1-associated Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes without Affecting Glucose Transport

1998 • 85 citations

Adenovirus-Mediated Overexpression of IRS-1 Interacting Domains Abolishes Insulin-Stimulated Mitogenesis without Affecting Glucose Transport in 3T3-L1 Adipocytes

1997 • 77 citations

Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1994 • 73 citations

A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake

1997 • 67 citations

Lithium Increases Susceptibility of Muscle Glucose Transport to Stimulation by Various Agents

1994 • 59 citations

Different Signaling Roles of SHPTP2 in Insulin-induced GLUT1 Expression and GLUT4 Translocation

1995 • 55 citations

Effects of lithium ions on glycogen synthase and phosphorylase in rat hepatocytes.

1986 • 49 citations

?Insulin-like? effects of lithium ion on isolated rat adipocytes II. Specific activation of glycogen synthase

1983 • 49 citations

A role for Raf-1 in the divergent signaling pathways mediating insulin-stimulated glucose transport

1994 • 48 citations

Insulin action in denervated skeletal muscle. Evidence that the reduced stimulation of glycogen synthesis does not involve decreased insulin binding.

1985 • 39 citations

ATP citrate-lyase and glycogen synthase kinase-3β in 3T3-L1 cells during differentiation into adipocytes

1994 • 36 citations

?Insulin-like? effects of lithium ion on isolated rat adipocytes I. Stimulation of glycogenesis beyond glucose transport

1983 • 35 citations

Characterization of the mitogen-activated protein kinase/90-kilodalton ribosomal protein S6 kinase signaling pathway in 3T3-L1 adipocytes and its role in insulin-stimulated glucose transport.

1994 • 33 citations

Cyclic nucleotide-independent protein kinase from rat liver. Purification and characterization of a multifunctional protein kinase.

1985 • 30 citations