p27^KIP1 Blocks Cyclin E-Dependent Transactivation of Cyclin A Gene Expression

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex

1996 • 889 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Cyclins and cancer

1991 • 701 citations

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1990 • 660 citations

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.

1994 • 659 citations

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family

1991 • 656 citations

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

1994 • 543 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

1994 • 493 citations

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1991 • 475 citations

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

1992 • 449 citations

Cyclins and cyclin-dependent kinases: take your partners

1993 • 441 citations

Shared role of the pRB-related p130 and p107 proteins in limb development.

1996 • 424 citations

A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression

1993 • 399 citations

Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

1994 • 393 citations

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.

1995 • 363 citations

Cell cycle-specific association of E2F with the p130 E1A-binding protein.

1993 • 348 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression.

1995 • 324 citations

Differential modulation of cyclin gene expression by MYC.

1993 • 321 citations

A new component of the transcription factor DRTF1/E2F

1993 • 293 citations

Cyclin A is required in S phase in normal epithelial cells

1992 • 273 citations

Structure and cell cycle-regulated transcription of the human cyclin A gene.

1994 • 272 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

1995 • 253 citations

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1992 • 239 citations

Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.

1995 • 237 citations

Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation

1995 • 195 citations

Cyclin A is required for the onset of DNA replication in mammalian fibroblasts

1992 • 185 citations

Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein

1994 • 143 citations

The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.

1995 • 135 citations

Origins of G₁ arrest in senescent human fibroblasts

1995 • 134 citations

Inducible acceleration of G1 progression through tetracycline-regulated expression of human cyclin E.

1994 • 129 citations

Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.

1996 • 115 citations

Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1

1993 • 113 citations

Mitotic control

1991 • 104 citations

Overexpression of human cyclin A advances entry into S phase.

1995 • 87 citations

p21 Disrupts the Interaction between cdk2 and the E2F-p130 Complex

1996 • 86 citations

Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1.

1994 • 45 citations

Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107

1996 • 35 citations

Molecular pathology of the cell cycle in human cancer cells

1993 • 21 citations