Regulatory T cell development in the absence of functional Foxp3

Bioconductor: open software development for computational biology and bioinformatics.

2004 • 11,755 citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

2006 • 1,496 citations

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006 • 1,135 citations

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

1996 • 1,124 citations

Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death

2004 • 972 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

2000 • 909 citations

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

2005 • 870 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

2006 • 773 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation

2001 • 551 citations

Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells

2005 • 525 citations

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

2006 • 523 citations

Activated CD4+CD25+ T cells selectively kill B lymphocytes

2006 • 484 citations

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation

2006 • 463 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis

2006 • 359 citations

Bonzo/CXCR6 expression defines type 1–polarized T-cell subsets with extralymphoid tissue homing potential

2001 • 352 citations

X-linked lymphoreticular disease in the scurfy (sf) mutant mouse.

1991 • 339 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

Activation events during thymic selection.

1992 • 326 citations

Origin and T Cell Receptor Diversity of Foxp3+CD4+CD25+ T Cells

2006 • 316 citations

Recent developments in the transcriptional regulation of cytolytic effector cells

2004 • 286 citations

Analysis of FOXP3 Reveals Multiple Domains Required for Its Function as a Transcriptional Repressor

2006 • 267 citations

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

2005 • 266 citations

Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression

2002 • 253 citations

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells

2004 • 238 citations

Regulatory T Cells Dynamically Control the Primary Immune Response to Foreign Antigen

2007 • 235 citations

Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice

2005 • 217 citations

The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome.

1990 • 195 citations

Structure of the Forkhead Domain of FOXP2 Bound to DNA

2006 • 191 citations

Defective T cell activation and autoimmune disorder in Stra13-deficient mice

2001 • 167 citations

A potential role for CD69 in thymocyte emigration

2002 • 144 citations

Indexation as a Novel Mechanism of Lymphocyte Homeostasis: The Number of CD4+CD25+ Regulatory T Cells Is Indexed to the Number of IL-2-Producing Cells

2006 • 135 citations

Administration of anti‐interleukin‐2 receptor α antibody in vivo induces localized autoimmune disease

1996 • 101 citations

Foxp3 ⁺ CD25 ⁺ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

2006 • 94 citations

Orphan nuclear receptors in T lymphocyte development

2002 • 62 citations

Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7

2006 • 42 citations