P-Glycoproteins and Multidrug Resistance

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.

1994 • 777 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

1994 • 635 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

P‐glycoprotein: multidrug‐resistance and a superfamily of membrane‐associated transport proteins

1989 • 512 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

1988 • 417 citations

The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

1987 • 384 citations

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression

1993 • 372 citations

Alternating Non-Cross-Resistant Combination Chemotherapy or MOPP in Stage IV Hodgkin's Disease

1986 • 370 citations

Isolation and characterization of a novel ribonucleoprotein particle: large structures contain a single species of small RNA.

1986 • 333 citations

Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity

1976 • 314 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein.

1993 • 297 citations

Structure and expression of the human MDR (P-glycoprotein) gene family.

1989 • 296 citations

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

1987 • 289 citations

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

1992 • 288 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis.

1991 • 261 citations

Identification of a sister gene to P-glycoprotein.

1995 • 236 citations

Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).

1987 • 229 citations

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26

1988 • 223 citations

Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance.

1992 • 221 citations

Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex

1993 • 214 citations

P-glycoprotein expression in human plasma cell myeloma: correlation with prior chemotherapy

1993 • 207 citations

Prediction of Doxorubicin Resistance In Vitro in Myeloma, Lymphoma, and Breast Cancer by P-Glycoprotein Staining

1989 • 202 citations

Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies.

1994 • 196 citations

Vaults. III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry.

1991 • 185 citations

Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia

1995 • 182 citations

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

1987 • 179 citations

Uptake and retention of daunomycin by mouse leukemic cells as factors in drug response.

1968 • 171 citations

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

1987 • 147 citations

P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines.

1989 • 144 citations

Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

1993 • 138 citations

Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia

1989 • 135 citations

Enhanced expression of the human multidrug resistance 1 gene in response to UV light irradiation.

1993 • 135 citations

Expression complementary DNA library transfer establishes mrp as a multidrug resistance gene.

1994 • 124 citations

The core promoter region of the P-glycoprotein gene is sufficient to confer differential responsiveness to wild-type and mutant p53.

1993 • 120 citations

Multidrug resistance in lymphomas.

1994 • 115 citations

Expression of the multidrug resistance-associated protein (MRP) in acute leukaemia.

1994 • 103 citations

Cloning and sequence analysis of the promoter region of the MRP gene of HL60 cells isolated for resistance to adriamycin.

1994 • 101 citations

Ribozyme-mediated reversal of the multidrug-resistant phenotype.

1994 • 93 citations

Phase I pharmacokinetic study of cyclosporin A combined with doxorubicin.

1993 • 91 citations

Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme

1994 • 86 citations

Clinical modulation of multidrug resistance in multiple myeloma: effect of cyclosporine on resistant tumor cells.

1994 • 83 citations

The Anatomic Basis of the Blood-Brain Barrier

1989 • 83 citations

Membrane topology of the N-terminal half of the hamster P-glycoprotein molecule

1993 • 82 citations

Expression of a Human Complementary DNA for the Multidrug Resistance Gene in Murine Hematopoietic Precursor Cells With the Use of Retroviral Gene Transfer

1990 • 80 citations

Modulation by verapamil of vincristine pharmacokinetics and toxicity in mice bearing human tumor xenografts

1989 • 78 citations

Phosphorylation of the Multidrug Resistance Encoded Protein P190

1995 • 56 citations

cDNA cloning and disruption of the major vault protein alpha gene (mvpA) in Dictyostelium discoideum

1993 • 47 citations

High expression of the multidrug resistance‐associated protein (MRP) in chronic and prolymphocytic leukaemia

1994 • 46 citations

Characteristics of Multidrug Resistance in Human Tumor Cells

1991 • 40 citations

An in vivo model of human multidrug-resistant multiple myeloma in SCID mice.

1993 • 35 citations

The inability of the mouse mdr2 gene to confer multidrug resistance is linked to reduced drug binding to the protein.

1994 • 34 citations

Pseudomonas Exotoxin Conjugated to Monoclonal Antibody MRK16 Specifically Kills Multidrug Resistant Cells in Cultured Renal Carcinomas and In Mdr-Transgenic Mice

1993 • 24 citations

Mdr1P-glycoprotein expression in natural killer (NK) cells enriched from peripheral or umbilical cord blood

1993 • 23 citations

Molecular and Cytogenetic Analysis of Multidrug Resistance-Associated Gene Amplification in Chinese Hamster, Mouse Sarcoma, and Human Neuroblastoma Cells

1991 • 15 citations

Circumvention of drug resistance with calcium channel blockers and monoclonal antibodies

1989 • 14 citations

The addition of cyclosporin A (CsA) results in markedly elevated tissue levels of doxorubicin (DOX) in the SCID mouse

1994 • 2 citations