Turning Tumors into Vaccines: Co-opting the Innate Immune System

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

2010 • 14,016 citations

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

2012 • 11,574 citations

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

2012 • 7,361 citations

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

2012 • 7,135 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Myeloid-derived suppressor cells as regulators of the immune system

2009 • 6,165 citations

Oncology Meets Immunology: The Cancer-Immunity Cycle

2013 • 5,543 citations

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

2010 • 5,069 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

2011 • 4,304 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

2010 • 3,500 citations

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

2013 • 3,290 citations

Clonal evolution in cancer

2012 • 2,892 citations

NF-κB: linking inflammation and immunity to cancer development and progression

2005 • 2,878 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

5'-Triphosphate RNA Is the Ligand for RIG-I

2006 • 2,329 citations

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

2010 • 2,120 citations

RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

2006 • 2,116 citations

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

2012 • 1,925 citations

Cancer as an evolutionary and ecological process

2006 • 1,658 citations

Adoptive immunotherapy for cancer: harnessing the T cell response

2012 • 1,570 citations

Immunological aspects of cancer chemotherapy

2007 • 1,535 citations

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

2011 • 1,515 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 1,499 citations

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

2012 • 1,160 citations

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

2010 • 1,030 citations

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

2009 • 1,027 citations

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

2012 • 960 citations

Ipilimumab in Combination With Paclitaxel and Carboplatin As First-Line Treatment in Stage IIIB/IV Non–Small-Cell Lung Cancer: Results From a Randomized, Double-Blind, Multicenter Phase II Study

2012 • 953 citations

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

2011 • 859 citations

Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues

2004 • 853 citations

Dendritic-Cell-Based Therapeutic Cancer Vaccines

2013 • 779 citations

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

2009 • 744 citations

The immunosuppressive tumour network: myeloid‐derived suppressor cells, regulatory T cells and natural killer T cells

2012 • 721 citations

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

2009 • 694 citations

Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

2006 • 681 citations

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

2009 • 679 citations

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

2012 • 674 citations

Ipilimumab (Anti-CTLA4 Antibody) Causes Regression of Metastatic Renal Cell Cancer Associated With Enteritis and Hypophysitis

2007 • 673 citations

CONTRIBUTION TO THE KNOWLEDGE OF SARCOMA

1891 • 656 citations

Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells

1999 • 580 citations

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

2012 • 559 citations

Deciphering and Reversing Tumor Immune Suppression

2013 • 535 citations

Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression

2006 • 531 citations

Expression of tumour-specific antigens underlies cancer immunoediting

2012 • 501 citations

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

2009 • 489 citations

Identification and manipulation of tumor associated macrophages in human cancers

2011 • 423 citations

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon–independent apoptosis in human melanoma cells

2009 • 421 citations

CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes

2010 • 390 citations

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

2008 • 376 citations

Interleukin-6 as a Therapeutic Target in Human Ovarian Cancer

2011 • 361 citations

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans

2008 • 331 citations

Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model

2011 • 326 citations

‘Cancer associated fibroblasts’ – more than meets the eye

2013 • 317 citations

IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors

2011 • 316 citations

Radiation as an immunological adjuvant: current evidence on dose and fractionation

2012 • 302 citations

The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice

2012 • 251 citations

Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

2012 • 239 citations

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

2010 • 238 citations

Antigen-Antibody Immune Complexes Empower Dendritic Cells to Efficiently Prime Specific CD8+ CTL Responses In Vivo

2002 • 235 citations

CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

2011 • 230 citations

Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell–licensed DCs

2010 • 224 citations

Phase II Randomized, Double-Blind, Placebo-Controlled Study of Tasquinimod in Men With Minimally Symptomatic Metastatic Castrate-Resistant Prostate Cancer

2011 • 207 citations

Programming for CD8 T Cell Memory Development Requires IL-12 or Type I IFN

2009 • 202 citations

Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory

2009 • 197 citations

Superior induction of anti‐tumor CTL immunity by extended peptide vaccines involves prolonged, DC‐focused antigen presentation

2008 • 197 citations

Part I: Vaccines for solid tumours

2004 • 197 citations

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients

2004 • 182 citations

The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells

2013 • 173 citations

Distinct Uptake Mechanisms but Similar Intracellular Processing of Two Different Toll-like Receptor Ligand-Peptide Conjugates in Dendritic Cells

2007 • 171 citations

The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice

2012 • 159 citations

Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity

2009 • 141 citations

Immunization with a P53 synthetic long peptide vaccine induces P53‐specific immune responses in ovarian cancer patients, a phase II trial

2009 • 139 citations

Therapeutic Efficacy of Bifunctional siRNA Combining TGF-β1 Silencing with RIG-I Activation in Pancreatic Cancer

2013 • 139 citations

Tumor-Specific CD4+ T Cells Render the Tumor Environment Permissive for Infiltration by Low-Avidity CD8+ T Cells

2008 • 137 citations

Efficient and versatile manipulation of the peripheral CD4⁺ T‐cell compartment by antigen targeting to DNGR‐1/CLEC9A

2010 • 127 citations

In situStimulation of CD40 and Toll-like Receptor 3 Transforms Ovarian Cancer–Infiltrating Dendritic Cells from Immunosuppressive to Immunostimulatory Cells

2009 • 127 citations

Anti‐<scp>IL</scp>‐6 receptor m<scp>A</scp>b eliminates myeloid‐derived suppressor cells and inhibits tumor growth by enhancing <scp>T</scp>‐cell responses

2012 • 121 citations

The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis

2011 • 119 citations

Protective CD8 T Cell Immunity Triggered by CpG-Protein Conjugates Competes with the Efficacy of Live Vaccines

2005 • 104 citations

Activation of Virus-Specific CD8+ T Cells by Lipopolysaccharide-Induced IL-12 and IL-18

2004 • 101 citations

Potentiation of a p53‐SLP vaccine by cyclophosphamide in ovarian cancer: A single‐arm phase II study

2011 • 89 citations

An Oncolytic Adenovirus Enhanced for Toll-like Receptor 9 Stimulation Increases Antitumor Immune Responses and Tumor Clearance

2012 • 89 citations

Cytokine-Mediated Programmed Proliferation of Virus-Specific CD8+ Memory T Cells

2012 • 83 citations

Increased primary cell-mediated immunity in culture subsequent to adriamycin or daunorubicin treatment of spleen donor mice.

1977 • 83 citations

TLR Ligand–Peptide Conjugate Vaccines

2012 • 79 citations

Activation of the NLRP3 inflammasome by intracellular poly I:C

2010 • 71 citations

NK Cell Response to Vaccinia Virus Is Regulated by Myeloid-Derived Suppressor Cells

2012 • 70 citations

Cancer immunotherapy

2012 • 69 citations

Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells

2012 • 66 citations

Long‐term clinical and immunological effects of p53‐SLP® vaccine in patients with ovarian cancer

2011 • 54 citations

Addition of interferon‐α to the p53‐SLP® vaccine results in increased production of interferon‐γ in vaccinated colorectal cancer patients: A phase I/II clinical trial

2012 • 53 citations

Complete Regression of Advanced Primary and Metastatic Mouse Melanomas following Combination Chemoimmunotherapy

2009 • 51 citations

IFN-α boosts epitope cross-presentation by dendritic cells via modulation of proteasome activity

2010 • 44 citations

Experience with Synthetic Vaccines for Cancer and Persistent Virus Infections in Nonhuman Primates and Patients

2012 • 35 citations

Autochthonous primary and metastatic melanomas in Hgf‐Cdk4^R24C mice evade T‐cell‐mediated immune surveillance

2010 • 34 citations

TRAIL/DR5 Plays a Critical Role in NK Cell-Mediated Negative Regulation of Dendritic Cell Cross-Priming of T Cells

2011 • 29 citations

Molecular mechanisms of radiation resistance in doxorubicin-resistant breast adenocarcinoma cells

2013 • 14 citations

Immunochemotherapy against colon cancer by gene transfer of interleukin-12 in combination with oxaliplatin

2012 • 11 citations

Negative Regulation of the Type I Interferon Signaling Pathway by Synthetic Toll-Like Receptor 7 Ligands

2012 • 8 citations