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2009 • 6,165 citations

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

2006 • 3,428 citations

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2006 • 2,050 citations

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

2009 • 1,676 citations

Immunosuppressive Strategies that are Mediated by Tumor Cells

2006 • 1,662 citations

Regulation of immune responses by L-arginine metabolism

2005 • 1,636 citations

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

2008 • 1,597 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

Altered macrophage differentiation and immune dysfunction in tumor development

2007 • 1,196 citations

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity

2008 • 1,185 citations

Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy

2008 • 1,184 citations

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

2010 • 1,128 citations

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

2007 • 1,079 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

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2008 • 865 citations

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

2009 • 836 citations

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2004 • 825 citations

Arginase-Producing Myeloid Suppressor Cells in Renal Cell Carcinoma Patients: A Mechanism of Tumor Evasion

2005 • 811 citations

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2009 • 706 citations

Modulation of the antitumor immune response by complement

2008 • 694 citations

Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives

2008 • 660 citations

Myeloid-derived suppressor cell heterogeneity and subset definition

2010 • 617 citations

Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice

2008 • 532 citations

All-trans-Retinoic Acid Improves Differentiation of Myeloid Cells and Immune Response in Cancer Patients

2006 • 529 citations

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

2005 • 462 citations

Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer

2004 • 458 citations

STAT1 Signaling Regulates Tumor-Associated Macrophage-Mediated T Cell Deletion

2005 • 431 citations

Immune Stimulatory Receptor CD40 Is Required for T-Cell Suppression and T Regulatory Cell Activation Mediated by Myeloid-Derived Suppressor Cells in Cancer

2009 • 429 citations

Macrophage Responses to Hypoxia

2005 • 405 citations

Mechanism of All-TransRetinoic Acid Effect on Tumor-Associated Myeloid-Derived Suppressor Cells

2007 • 391 citations

Role Of Immature Myeloid Cells in Mechanisms of Immune Evasion In Cancer

2005 • 352 citations

Tumor-Associated CD8+ T Cell Tolerance Induced by Bone Marrow-Derived Immature Myeloid Cells

2005 • 302 citations

Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species

2003 • 289 citations

Reversal of Myeloid Cell–Mediated Immunosuppression in Patients with Metastatic Renal Cell Carcinoma

2008 • 278 citations

Pathways Mediating the Expansion and Immunosuppressive Activity of Myeloid-Derived Suppressor Cells and Their Relevance to Cancer Therapy

2007 • 265 citations

Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer

2010 • 261 citations

Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma.

2002 • 214 citations

Cutting Edge: Hypoxia-Inducible Factor 1α and Its Activation-Inducible Short Isoform I.1 Negatively Regulate Functions of CD4+ and CD8+ T Lymphocytes

2006 • 197 citations

Vascular Endothelial Growth Factor-Trap Overcomes Defects in Dendritic Cell Differentiation but Does Not Improve Antigen-Specific Immune Responses

2007 • 177 citations

Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress–induced cell death

2008 • 176 citations

Tumor-induced interleukin 10 suppresses the ability of splenic dendritic cells to stimulate CD4 and CD8 T-cell responses.

2003 • 168 citations

Targeted Deletion of HIF-1α Gene in T Cells Prevents their Inhibition in Hypoxic Inflamed Tissues and Improves Septic Mice Survival

2007 • 166 citations

Expression and activity of signaling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after interleukin 2 therapy.

1996 • 111 citations

Mice Bearing Late-Stage Tumors Have Normal Functional Systemic T Cell Responses In Vitro and In Vivo

2000 • 79 citations

Suppression of Proximal T Cell Receptor Signaling and Lytic Function in CD8+ Tumor-Infiltrating T Cells

2007 • 65 citations

Conversion of Tyrosine to the Inflammation-Associated Analog 3′-Nitrotyrosine at Either TCR- or MHC-Contact Positions Can Profoundly Affect Recognition of the MHC Class I-Restricted Epitope of Lymphocytic Choriomeningitis Virus Glycoprotein 33 by CD8 T Cells

2008 • 55 citations

Cyclin-dependent kinase inhibitor expression in pulmonary Clara cells transformed with SV40 large T antigen in transgenic mice.

1997 • 45 citations

Oxygen and the regulation of gene expression in wounds

2003 • 42 citations

NO‐Mediated Chemoresistance in C6 Glioma Cells

2002 • 33 citations

Repression of Interleukin-2 mRNA Translation in Primary Human Breast Carcinoma Tumor-Infiltrating Lymphocytes

1998 • 33 citations

Analysis of splenic Gr‐1^int immature myeloid cells in tumor‐bearing mice

2008 • 22 citations

Myeloid suppressor cell‐associated immune dysfunction in CSA1M fibrosarcoma tumor‐bearing mice

2007 • 19 citations

Hypoxia, HIFs, and Cardiovascular Development

2002 • 17 citations