The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 • 2,814 citations

Batf3 Deficiency Reveals a Critical Role for CD8α ⁺ Dendritic Cells in Cytotoxic T Cell Immunity

2008 • 1,781 citations

Differential Antigen Processing by Dendritic Cell Subsets in Vivo

2007 • 1,378 citations

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

2000 • 1,286 citations

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

2007 • 1,133 citations

Immunogenic and tolerogenic cell death

2009 • 1,075 citations

Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

2010 • 954 citations

Toll-like receptor 3 promotes cross-priming to virus-infected cells

2005 • 902 citations

NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells

2006 • 824 citations

Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

2006 • 794 citations

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells

2010 • 755 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate

2005 • 722 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming

2006 • 716 citations

CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses

2009 • 701 citations

The origin and development of nonlymphoid tissue CD103+ DCs

2009 • 690 citations

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

2009 • 680 citations

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

2009 • 679 citations

Localization, Quantitation, and In Situ Detection of Specific Peptide–MHC Class I Complexes Using a Monoclonal Antibody

1997 • 679 citations

Mincle is an ITAM-coupled activating receptor that senses damaged cells

2008 • 677 citations

Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo

2007 • 668 citations

Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells

2010 • 650 citations

The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo

2002 • 641 citations

Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells

2010 • 639 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation

2007 • 592 citations

Epidermal Viral Immunity Induced by CD8α ⁺ Dendritic Cells But Not by Langerhans Cells

2003 • 580 citations

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+ dendritic cells

2010 • 568 citations

Cutting Edge: Generation of Splenic CD8+ and CD8− Dendritic Cell Equivalents in Fms-Like Tyrosine Kinase 3 Ligand Bone Marrow Cultures

2005 • 520 citations

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

2008 • 492 citations

The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens

2002 • 468 citations

Clearance of influenza virus from the lung depends on migratory langerin+CD11b− but not plasmacytoid dendritic cells

2008 • 465 citations

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

2008 • 436 citations

CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens

2010 • 410 citations

Dendritic cell subsets in primary and secondary T cell responses at body surfaces

2009 • 409 citations

Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens.

1992 • 407 citations

Dendritic cell homeostasis

2009 • 383 citations

The dominant role of CD8⁺dendritic cells in cross-presentation is not dictated by antigen capture

2006 • 377 citations

Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus

2004 • 374 citations

F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells

2012 • 362 citations

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

2009 • 348 citations

CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

1997 • 320 citations

Cutting Edge: Conventional CD8α+ Dendritic Cells Are Generally Involved in Priming CTL Immunity to Viruses

2004 • 298 citations

CLEC9A Is a Novel Activation C-type Lectin-like Receptor Expressed on BDCA3+ Dendritic Cells and a Subset of Monocytes

2008 • 297 citations

Dendritic cells: versatile controllers of the immune system

2007 • 295 citations

Sec22b Regulates Phagosomal Maturation and Antigen Crosspresentation by Dendritic Cells

2011 • 290 citations

Dendritic Cells In Vivo: A Key Target for a New Vaccine Science

2008 • 265 citations

Two-Helper RNA System for Production of Recombinant Semliki Forest Virus Particles

1999 • 258 citations

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.

1982 • 252 citations

Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes

2007 • 232 citations

DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues

2012 • 226 citations

The C-type Lectin Receptors CLEC-2 and Dectin-1, but Not DC-SIGN, Signal via a Novel YXXL-dependent Signaling Cascade

2007 • 215 citations

Cross‐presentation of cell‐associated antigens by CD8α⁺ dendritic cells is attributable to their ability to internalize dead cells

2002 • 214 citations

Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype

2011 • 212 citations

Origin and functional heterogeneity of non‐lymphoid tissue dendritic cells in mice

2010 • 207 citations

Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo

2005 • 204 citations

Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis

2006 • 197 citations

Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells

2009 • 193 citations

Uptake of Apoptotic Antigen-Coupled Cells by Lymphoid Dendritic Cells and Cross-Priming of CD8+ T Cells Produce Active Immune Unresponsiveness

2002 • 193 citations

Novel Subset of CD8α+ Dendritic Cells Localized in the Marginal Zone Is Responsible for Tolerance to Cell-Associated Antigens

2009 • 188 citations

Antigen presentation by dendritic cells in vivo

2009 • 164 citations

The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice

2012 • 159 citations

Constitutive Crosspresentation of Tissue Antigens by Dendritic Cells Controls CD8+ T Cell Tolerance In Vivo

2008 • 131 citations

Efficient and versatile manipulation of the peripheral CD4⁺ T‐cell compartment by antigen targeting to DNGR‐1/CLEC9A

2010 • 127 citations

Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation

2009 • 116 citations

Existence of CD8α-Like Dendritic Cells with a Conserved Functional Specialization and a Common Molecular Signature in Distant Mammalian Species

2010 • 105 citations

Lasker Basic Medical Research Award

2002 • 100 citations

Apoptotic Cells Induce Tolerance by Generating Helpless CD8+ T Cells That Produce TRAIL

2007 • 87 citations

Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation

2011 • 80 citations

NK cells contribute to the early clearance of HSV‐1 from the lung but cannot control replication in the central nervous system following intranasal infection

2006 • 49 citations

Targeting to Static Endosome Is Required for Efficient Cross-Presentation of Endoplasmic Reticulum-Resident Oxygen-Regulated Protein 150-Peptide Complexes

2009 • 25 citations

Death, danger, and immunity: an infernal trio

2007 • 22 citations