‘Cancer associated fibroblasts’ – more than meets the eye

Fibroblasts in cancer

2006 • 4,177 citations

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

2009 • 2,945 citations

The Extended Phenotype

1982 • 2,559 citations

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

2012 • 1,673 citations

Stromal gene expression predicts clinical outcome in breast cancer

2008 • 1,633 citations

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

2000 • 1,445 citations

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

2010 • 1,359 citations

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

2004 • 1,346 citations

Molecular characterization of the tumor microenvironment in breast cancer

2004 • 1,278 citations

Interactions between cancer stem cells and their niche govern metastatic colonization

2011 • 1,246 citations

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

2012 • 1,204 citations

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α

2010 • 1,004 citations

Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival

2005 • 956 citations

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

2012 • 945 citations

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

2011 • 942 citations

Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts

2007 • 881 citations

Carcinoma-Associated Fibroblast–Like Differentiation of Human Mesenchymal Stem Cells

2008 • 849 citations

PAR1 Is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells

2005 • 808 citations

A Pericyte Origin of Spinal Cord Scar Tissue

2011 • 789 citations

Reconstruction of functionally normal and malignant human breast tissues in mice

2004 • 777 citations

Identification of fibroblast heterogeneity in the tumor microenvironment

2006 • 657 citations

Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

2011 • 618 citations

Cancer associated fibroblasts (CAFs) in tumor microenvironment

2009 • 608 citations

Gene expression profiling of the tumor microenvironment during breast cancer progression

2009 • 602 citations

PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment

2009 • 579 citations

Role of chemokines in tumor growth

2007 • 553 citations

PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

2005 • 538 citations

Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts

2004 • 515 citations

Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity

1994 • 431 citations

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

2002 • 424 citations

A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer.

2003 • 404 citations

Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis.

2000 • 400 citations

Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury

2012 • 382 citations

Cancer associated fibroblasts in cancer pathogenesis

2009 • 378 citations

Role of the stromal microenvironment in carcinogenesis of the prostate

2003 • 362 citations

Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer.

2003 • 344 citations

Stromal cells can contribute oncogenic signals

2001 • 326 citations

The Tumor Microenvironment Contribution to Development, Growth, Invasion and Metastasis of Head and Neck Squamous Cell Carcinomas

2013 • 325 citations

Breast-Cancer Stromal Cells withTP53Mutations and Nodal Metastases

2007 • 293 citations

Epithelial to Mesenchymal Transition in Human Breast Cancer Can Provide a Nonmalignant Stroma

2003 • 291 citations

Cross-talk between Paracrine-Acting Cytokine and Chemokine Pathways Promotes Malignancy in Benign Human Prostatic Epithelium

2007 • 277 citations

Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction

2003 • 276 citations

Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis

2012 • 264 citations

Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs

2007 • 252 citations

Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer

2011 • 237 citations

Adipose tissue-derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor-derived factors.

2010 • 225 citations

Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer

2008 • 219 citations

Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.

1991 • 217 citations

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

2011 • 194 citations

PT-100, a Small Molecule Dipeptidyl Peptidase Inhibitor, Has Potent Antitumor Effects and Augments Antibody-Mediated Cytotoxicity via a Novel Immune Mechanism

2004 • 179 citations

Stromal Fibroblasts in Colorectal Liver Metastases Originate From Resident Fibroblasts and Generate an Inflammatory Microenvironment

2007 • 171 citations

Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors

2011 • 165 citations

Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers

2010 • 161 citations

Precise microdissection of human prostate cancers reveals genotypic heterogeneity.

1998 • 159 citations

Inflammation, carcinogenesis and cancer

2001 • 149 citations

Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts

1993 • 146 citations

Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy?

2009 • 141 citations

Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 down-regulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy

2008 • 138 citations

Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients

2009 • 135 citations

Tumor-dependent activation of rodent hepatic stellate cells during experimental melanoma metastasis

1997 • 135 citations

CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesions

2001 • 132 citations

Cancer‐associated fibroblasts and epithelial‐mesenchymal transition in metastatic oral tongue squamous cell carcinoma

2010 • 122 citations

Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/ -catenin signalling pathway

2011 • 116 citations

Genomic Instability Within Tumor Stroma and Clinicopathological Characteristics of Sporadic Primary Invasive Breast Carcinoma

2007 • 113 citations

Leptin Mediates Tumor–Stromal Interactions That Promote the Invasive Growth of Breast Cancer Cells

2012 • 113 citations

Interleukin 1α Sustains the Expression of Inflammatory Factors in Human Pancreatic Cancer Microenvironment by Targeting Cancer-Associated Fibroblasts

2011 • 106 citations

Role of epithelial-mesenchymal interactions in the differentiation and spatial organization of visceral smooth muscle.

1992 • 102 citations

Paracrine/autocrine regulation of breast cancer by the insulin-like growth factors

1998 • 101 citations

Breast cancer stromal fibroblasts promote the generation of CD44+CD24- cells through SDF-1/CXCR4 interaction

2010 • 100 citations

Human Gastrointestinal Neoplasia-Associated Myofibroblasts Can Develop from Bone Marrow-Derived Cells Following Allogeneic Stem Cell Transplantation

2009 • 96 citations

Presence of genetic alterations in microdissected stroma of human colon and breast cancers.

2001 • 95 citations

Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1

2009 • 84 citations

CXCR4 and Matrix Metalloproteinase-1 Are Elevated in Breast Carcinoma–Associated Fibroblasts and in Normal Mammary Fibroblasts Exposed to Factors Secreted by Breast Cancer Cells

2009 • 83 citations

Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling

2012 • 83 citations

Breast Carcinoma–Associated Fibroblasts Rarely Contain p53 Mutations or Chromosomal Aberrations

2010 • 81 citations

Modulated expression of WFDC1 during carcinogenesis and cellular senescence

2008 • 78 citations

Cancer-Associated Fibroblasts Derived from EGFR-TKI–Resistant Tumors Reverse EGFR Pathway Inhibition by EGFR-TKIs

2010 • 77 citations

Tumor‐promoting phenotype of CD90^hi prostate cancer‐associated fibroblasts

2009 • 76 citations

Pancreatic cancer associated fibroblasts display normal allelotypes

2008 • 76 citations

Generation of a FasL-based Proapoptotic Fusion Protein Devoid of Systemic Toxicity due to Cell-surface Antigen-restricted Activation

2003 • 73 citations

Can cancer cells transform normal host cells into malignant cells?

1997 • 69 citations

Mesenchymal Stem Cells in drug/gene Delivery: Implications for Cell Therapy

2012 • 64 citations

Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast

2010 • 60 citations

Separation, cultivation and biological characteristics of oral carcinoma‐associated fibroblasts

2006 • 51 citations

TNF-α similarly induces IL-6 and MCP-1 in fibroblasts from colorectal liver metastases and normal liver fibroblasts

2010 • 50 citations

Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity

2012 • 46 citations

Imaging the recruitment of cancer‐associated fibroblasts by liver‐metastatic colon cancer

2010 • 44 citations

Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression

2011 • 42 citations

Expression and role of fibroblast activation protein-alpha in microinvasive breast carcinoma

2011 • 41 citations

Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta

2013 • 38 citations

Collective invasion of carcinoma cells

2008 • 36 citations

Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas

2006 • 36 citations

Stromal biomarkers in breast cancer development and progression

2012 • 35 citations

Differences in the Nemosis Response of Normal and Cancer-Associated Fibroblasts from Patients with Oral Squamous Cell Carcinoma

2009 • 35 citations

Functional characterization of cancer‐associated fibroblasts of human cutaneous squamous cell carcinoma

2011 • 33 citations

Biology of Stem Cells and the Molecular Basis of the Stem State

2009 • 26 citations

Creating a tumor-resistant microenvironment: Cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo

2013 • 26 citations

The Origin of Stroma Surrounding Epithelial Ovarian Cancer Cells

2012 • 13 citations

Ras Oncoproteins Transfer from Melanoma Cells to T Cells and Modulate Their Effector Functions

2012 • 8 citations

Functional Assessment of Fibroblast Heterogeneity by the Cell-Surface Glycoprotein Thy-1

2007 • 4 citations

Deleted Work

1955 • 0 citations