Cytokine-Mediated Programmed Proliferation of Virus-Specific CD8+ Memory T Cells

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

T Cell Activation

2009 • 1,898 citations

Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

2003 • 1,466 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

2003 • 1,220 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

2006 • 1,092 citations

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

2006 • 1,081 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

2010 • 721 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

2008 • 594 citations

Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4

2004 • 547 citations

IL-21 Is Required to Control Chronic Viral Infection

2009 • 536 citations

Early Programming of T Cell Populations Responding to Bacterial Infection

2000 • 492 citations

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

2009 • 490 citations

Cutting Edge: Naive T Cells Masquerading as Memory Cells

2000 • 476 citations

Dynamic programming of CD8+ T lymphocyte responses

2003 • 401 citations

Linear Differentiation of Cytotoxic Effectors into Memory T Lymphocytes

1999 • 393 citations

T Cell Stimulation In Vivo by Lipopolysaccharide (LPS)

1997 • 335 citations

Memory CD8+ T Cells Provide Innate Immune Protection against Listeria monocytogenes in the Absence of Cognate Antigen

2003 • 326 citations

CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

1996 • 300 citations

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge

1996 • 287 citations

Bystander Activation of CD8+ T Cells Contributes to the Rapid Production of IFN-γ in Response to Bacterial Pathogens

2001 • 284 citations

Cutting Edge: Antigen-Independent CD8 T Cell Proliferation

2001 • 277 citations

T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens

2002 • 259 citations

Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells

2011 • 234 citations

Diversity of Epitope and Cytokine Profiles for Primary and Secondary Influenza A Virus-Specific CD8+ T Cell Responses

2001 • 207 citations

Regulation of innate CD8 ⁺ T-cell activation mediated by cytokines

2012 • 203 citations

The role of programming in memory T-cell development

2004 • 195 citations

Bystander Activation of Cytotoxic T Cells: Studies on the Mechanism and Evaluation of In Vivo Significance in a Transgenic Mouse Model

1997 • 176 citations

Activated and Memory CD8+ T Cells Can Be Distinguished by Their Cytokine Profiles and Phenotypic Markers

2000 • 174 citations

Contribution of CD8+ T cells to innate immunity: IFN-γ secretion induced by IL-12 and IL-18

2002 • 168 citations

CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection

1996 • 154 citations

Memory CD8+ T Cells Provide an Early Source of IFN-γ

2003 • 141 citations

Role of CD40 Ligand and CD28 in Induction and Maintenance of Antiviral CD8+ Effector T Cell Responses

2000 • 126 citations

Quantitating the Magnitude of the Lymphocytic Choriomeningitis Virus-Specific CD8 T-Cell Response: It Is Even Bigger than We Thought

2006 • 109 citations

An IFN-γ-Dependent Pathway Controls Stimulation of Memory Phenotype CD8+ T Cell Turnover In Vivo by IL-12, IL-18, and IFN-γ

2001 • 106 citations

Repeated Antigen Exposure Is Necessary for the Differentiation, But Not the Initial Proliferation, of Naive CD4+ T Cells

2002 • 102 citations

Activation of Virus-Specific CD8+ T Cells by Lipopolysaccharide-Induced IL-12 and IL-18

2004 • 101 citations

IL-6, in Synergy with IL-7 or IL-15, Stimulates TCR-Independent Proliferation and Functional Differentiation of CD8+ T Lymphocytes

2008 • 99 citations

Dynamics of Memory T Cell Proliferation Under Conditions of Heterologous Immunity and Bystander Stimulation

2002 • 93 citations

Synergism for cytokine-mediated disease during concurrent endotoxin and viral challenges: roles for NK and T cell IFN-gamma production.

1999 • 82 citations

Signalling, inflammation and arthritis: Crossed signals: the role of interleukin-15 and -18 in autoimmunity

2008 • 70 citations

Synergism for Cytokine-Mediated Disease During Concurrent Endotoxin and Viral Challenges: Roles for NK and T Cell IFN-γ Production

1999 • 69 citations

Distinct Thresholds for CD8 T Cell Activation Lead to Functional Heterogeneity: CD8 T Cell Priming Can Occur Independently of Cell Division

2003 • 53 citations

Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines

2004 • 50 citations

Disparate In Vitro and In Vivo Requirements for IL-2 During Antigen-Independent CD8 T Cell Expansion

2004 • 36 citations

Temporal cross‐talk between TCR and STAT signals for CD8 T cell effector differentiation

2006 • 24 citations

Duration of CTL activation regulates IL‐2 production required for autonomous clonal expansion

2006 • 18 citations