Human CD8+ T-cell differentiation in response to viruses

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Effector and memory T-cell differentiation: implications for vaccine development

2002 • 1,757 citations

The lineage decisions of helper T cells

2002 • 1,678 citations

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

2003 • 1,623 citations

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

2002 • 1,583 citations

Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

2003 • 1,466 citations

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

1997 • 1,391 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

2000 • 1,270 citations

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

2003 • 1,220 citations

Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection

2001 • 1,183 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

Skewed maturation of memory HIV-specific CD8 T lymphocytes

2001 • 1,025 citations

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

2003 • 999 citations

Molecular and Functional Profiling of Memory CD8 T Cell Differentiation

2002 • 962 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

1998 • 902 citations

Cytokine control of memory T-cell development and survival

2003 • 885 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

1994 • 788 citations

Cytomegalovirus Seropositivity Drives the CD8 T Cell Repertoire Toward Greater Clonality in Healthy Elderly Individuals

2002 • 753 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

CD27 is required for generation and long-term maintenance of T cell immunity

2000 • 726 citations

Cellular immune responses to HIV

2001 • 639 citations

Programmed contraction of CD8+ T cells after infection

2002 • 586 citations

Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines

2003 • 582 citations

Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy

2001 • 535 citations

Understanding dendritic cell and T‐lymphocyte traffic through the analysis of chemokine receptor expression

2000 • 526 citations

Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.

1986 • 515 citations

The CTL's kiss of death

1995 • 504 citations

Sticky sugars for selectins

1991 • 456 citations

CD8 T Cell Responses to Infectious Pathogens

2003 • 433 citations

Quantitative analysis of hepatitis C virus-specific CD8⁺T cells in peripheral blood and liver using peptide-MHC tetramers

1999 • 421 citations

Primary immune responses to human CMV: a critical role for IFN-γ–producing CD4+ T cells in protection against CMV disease

2003 • 421 citations

CD28- T lymphocytes. Antigenic and functional properties.

1993 • 403 citations

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts.

1996 • 378 citations

Interconversion of CD45R subsets of CD4 T cells in vivo

1990 • 371 citations

CCR7 Expression and Memory T Cell Diversity in Humans

2001 • 342 citations

Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens.

1987 • 327 citations

CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained

2000 • 313 citations

Epitope-specific Evolution of Human CD8+ T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection

2002 • 310 citations

Cytomegalovirus (CMV) Phosphoprotein 65 Makes a Large Contribution to Shaping the T Cell Repertoire in CMV‐Exposed Individuals

2002 • 285 citations

Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor

1993 • 280 citations

Attrition of T Cell Memory

1999 • 278 citations

Human atopen-specific types 1 and 2 T helper cell clones.

1991 • 273 citations

Cutting Edge: Cytolytic Effector Function in Human Circulating CD8+ T Cells Closely Correlates with CD56 Surface Expression

2000 • 263 citations

Human CD8+ T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations.

1996 • 249 citations

Regulation of CD27 expression on subsets of mature T-lymphocytes.

1993 • 247 citations

Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNγ-Mediated B Cell Depletion

2001 • 237 citations

Mature CD8+ T lymphocyte response to viral infection during fetal life

2003 • 237 citations

Differentiation of Human CD8+ T Cells from a Memory to Memory/Effector Phenotype

2002 • 224 citations

EBV-Specific CD8+ T Cell Memory: Relationships Between Epitope Specificity, Cell Phenotype, and Immediate Effector Function

2001 • 223 citations

Mature CD8+ T lymphocyte response to viral infection during fetal life

2003 • 219 citations

Identification of Naive or Antigen-Experienced Human CD8+ T Cells by Expression of Costimulation and Chemokine Receptors: Analysis of the Human Cytomegalovirus-Specific CD8+ T Cell Response

2002 • 216 citations

Differentiation of cytomegalovirus-specific CD8+ T cells in healthy and immunosuppressed virus carriers

2001 • 215 citations

Cutting Edge: CCR7+ and CCR7− Memory T Cells Do Not Differ in Immediate Effector Cell Function

2002 • 204 citations

Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions

2003 • 191 citations

Evidence that human CD8+CD45RA+CD27– cells are induced by antigen and evolve through extensive rounds of division

1999 • 190 citations

Virus-Specific CD8⁺Lymphocytes Share the Same Effector-Memory Phenotype but Exhibit Functional Differences in Acute Hepatitis B and C

2002 • 174 citations

Premature ageing of the immune system: the cause of AIDS?

2002 • 173 citations

Frequencies of Circulating Cytolytic, CD45RA+CD27−, CD8+ T Lymphocytes Depend on Infection with CMV

2003 • 169 citations

CD27: marker and mediator of T-cell activation?

1994 • 169 citations

CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection

2001 • 166 citations

Regulatory roles of carbohydrate ligands for selectins in the homing of lymphocytes

2002 • 164 citations

IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro

2003 • 164 citations

CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus.

1995 • 160 citations

Altered representation of naive and memory CD8 T cell subsets in HIV-infected children.

1995 • 160 citations

Functional Heterogeneity of Cytokines and Cytolytic Effector Molecules in Human CD8+ T Lymphocytes

2001 • 158 citations

Longitudinal Phenotypic Analysis of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes: Correlation with Disease Progression

1999 • 157 citations

The CD27⁻ subset of peripheral blood memory CD4⁺ lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo

1992 • 157 citations

The Repertoires of Circulating Human CD8+ Central and Effector Memory T Cell Subsets Are Largely Distinct

2003 • 154 citations

Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms

1999 • 152 citations

Proliferation Requirements of Cytomegalovirus-Specific, Effector-Type Human CD8+ T Cells

2002 • 149 citations

Dynamics of T Cell Responses in HIV Infection

2002 • 145 citations

A Shift in the Phenotype of Melan-A-Specific CTL Identifies Melanoma Patients with an Active Tumor-Specific Immune Response

2000 • 138 citations

Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: human CD8 memory CTLp selectively express CD45R0 (UCHL1)

1989 • 138 citations

Increased Activated Human T Cell Lymphotropic Virus Type I (HTLV‐I) Tax11‐19–Specific Memory and Effector CD8⁺Cells in Patients with HTLV‐I–Associated Myelopathy/Tropical Spastic Paraparesis: Correlation with HTLV‐I Provirus Load

2001 • 128 citations

A role for antigen in the maintenance of immunological memory

2002 • 126 citations

Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue

2002 • 119 citations

Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation.

1991 • 118 citations

CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling.

1993 • 116 citations

Both CD45RA+ and CD45RA- subpopulations of CD8+ T cells contain cells with high levels of lymphocyte function-associated antigen-1 expression, a phenotype of primed T cells.

1993 • 112 citations

Changes in the Composition of Circulating CD8⁺T Cell Subsets during Acute Epstein‐Barr and Human Immunodeficiency Virus Infections in Humans

2000 • 105 citations

Isoforms of the transmembrane tyrosine phosphatase cd45 differentially affect T cell recognition

1994 • 105 citations

Immediate Early Effector Functions of Virus-Specific CD8+CCR7+ Memory Cells in Humans Defined by HLA and CC Chemokine Ligand 19 Tetramers

2003 • 97 citations

The Activatory Receptor 2B4 Is Expressed In Vivo by Human CD8+ Effector αβ T Cells

2001 • 94 citations

Distribution and functional analysis of memory antiviral CD8 T cell responses in HIV-1 and cytomegalovirus infections

2002 • 93 citations

Phenotypic and Functional Heterogeneity of EBV Epitope-Specific CD8+ T Cells

2002 • 87 citations

Cytolytic Mechanisms and Expression of Activation-Regulating Receptors on Effector-Type CD8+CD45RA+CD27− Human T Cells

2000 • 77 citations

Phenotype and function of human B cells expressing CD70 (CD27 ligand)

1996 • 75 citations

T cell selection during the evolution of CD8+ T cell memoryin vivo

1998 • 70 citations

Lack of Epstein-Barr virus- and HIV-specific CD27− CD8+ T cells is associated with progression to viral disease in HIV-infection

2002 • 68 citations

Antigen Burden Is a Major Determinant of Human Immunodeficiency Virus–Specific CD8⁺T Cell Maturation State: Potential Implications for Therapeutic Immunization

2003 • 65 citations

Cytotoxic T Cells Specific for Cytomegalovirus: A Potential Therapy for Immunocompromised Patients

1991 • 65 citations

Analysis of the Frequencies and of the Memory T Cell Phenotypes of Human CD8⁺T Cells Specific for Influenza A Viruses

2003 • 64 citations

Detection of virus-specific T cells and CD8+ T-cell epitopes by acquisition of peptide–HLA-GFP complexes: analysis of T-cell phenotype and function in chronic viral infections

2003 • 63 citations

Latent Herpesviruses of Humans

1984 • 56 citations