Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

2002 • 1,583 citations

Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

1998 • 1,426 citations

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

1997 • 1,391 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients

1998 • 1,103 citations

Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes

1996 • 1,085 citations

Skewed maturation of memory HIV-specific CD8 T lymphocytes

2001 • 1,025 citations

Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

1998 • 902 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.

1995 • 650 citations

High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors

1995 • 519 citations

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.

1996 • 515 citations

CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.

1997 • 493 citations

Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8⁺T Lymphocytes in Healthy Seropositive Donors

2000 • 438 citations

CD28- T lymphocytes. Antigenic and functional properties.

1993 • 403 citations

In vivo migration and function of transferred HIV-1-specific cytotoxic T cells

1999 • 341 citations

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice

1994 • 321 citations

Epitope-specific Evolution of Human CD8+ T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection

2002 • 310 citations

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge

1996 • 287 citations

Accessing Complexity: The Dynamics of Virus-Specific T Cell Responses

2000 • 283 citations

Regulation of CD27 expression on subsets of mature T-lymphocytes.

1993 • 247 citations

Differentiation of Human CD8+ T Cells from a Memory to Memory/Effector Phenotype

2002 • 224 citations

EBV-Specific CD8+ T Cell Memory: Relationships Between Epitope Specificity, Cell Phenotype, and Immediate Effector Function

2001 • 223 citations

Identification of Naive or Antigen-Experienced Human CD8+ T Cells by Expression of Costimulation and Chemokine Receptors: Analysis of the Human Cytomegalovirus-Specific CD8+ T Cell Response

2002 • 216 citations

Differentiation of cytomegalovirus-specific CD8+ T cells in healthy and immunosuppressed virus carriers

2001 • 215 citations

Evidence that human CD8+CD45RA+CD27– cells are induced by antigen and evolve through extensive rounds of division

1999 • 190 citations

Faces and phases of human CD8+ T-cell development

1999 • 187 citations

Persistent numbers of tetramer+ CD8+ T cells, but loss of interferon-γ+ HIV-specific T cells during progression to AIDS

2002 • 186 citations

High viral burden in the presence of major HIV-specific CD8+ T cell expansions: evidence for impaired CTL effector function

2001 • 185 citations

Dysfunctional Epstein-Barr virus (EBV)–specific CD8+T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma

2001 • 169 citations

CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection

2001 • 166 citations

Longitudinal Phenotypic Analysis of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes: Correlation with Disease Progression

1999 • 157 citations

The importance of lytic and nonlytic immune responses in viral infections

2002 • 156 citations

Epstein-Barr virus–specific CD8+ T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential

2002 • 151 citations

A Shift in the Phenotype of Melan-A-Specific CTL Identifies Melanoma Patients with an Active Tumor-Specific Immune Response

2000 • 138 citations

Increased Activated Human T Cell Lymphotropic Virus Type I (HTLV‐I) Tax11‐19–Specific Memory and Effector CD8⁺Cells in Patients with HTLV‐I–Associated Myelopathy/Tropical Spastic Paraparesis: Correlation with HTLV‐I Provirus Load

2001 • 128 citations

Critical Role for CD4⁺T Cells in Controlling Retrovirus Replication and Spread in Persistently Infected Mice

1998 • 125 citations

Changes in the Composition of Circulating CD8⁺T Cell Subsets during Acute Epstein‐Barr and Human Immunodeficiency Virus Infections in Humans

2000 • 105 citations

Longitudinal Analysis of Human Immunodeficiency Virus Type 1‐Specific Cytotoxic T Lymphocyte Responses: A Predominant Gag‐Specific Response Is Associated with Nonprogressive Infection

1998 • 102 citations

HIV: current opinion in escapology

2002 • 94 citations

Phenotypic and Functional Heterogeneity of EBV Epitope-Specific CD8+ T Cells

2002 • 87 citations

Epstein-Barr virus-specific cytotoxic T cell responses in HIV-1 infection: different kinetics in patients progressing to opportunistic infection or non-Hodgkin's lymphoma.

1997 • 84 citations

Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection

2000 • 82 citations

Absolute Level of Epstein‐Barr Virus DNA in Human Immunodeficiency Virus Type 1 Infection Is Not Predictive of AIDS‐Related Non‐Hodgkin Lymphoma

2002 • 80 citations

Analysis of the cytolytic T lymphocyte response of melanoma patients to the naturally HLA-A*0201-associated tyrosinase peptide 368-376.

1999 • 71 citations

Frequent cytolytic T-cell responses to peptide MAGE-A10(254-262) in melanoma.

2001 • 70 citations

Lack of Epstein-Barr virus- and HIV-specific CD27− CD8+ T cells is associated with progression to viral disease in HIV-infection

2002 • 68 citations

High Frequency of Cytomegalovirus‐Specific Cytotoxic T‐Effector Cells in HLA‐A*0201–Positive Subjects during Multiple Viral Coinfections

2000 • 67 citations

Avoiding the kiss of death: how HIV and other chronic viruses survive

2002 • 37 citations