Urokinase plasminogen activator (uPA) and its type 1 inhibitor (PAI-1): Regulators of proteolysis during cancer invasion and prognostic parameters in Breast cancer

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.

1985 • 731 citations

Antibodies to plasminogen activator inhibit human tumor metastasis

1983 • 651 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1991 • 578 citations

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

1990 • 545 citations

Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor

1991 • 509 citations

Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules

1985 • 492 citations

Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).

1988 • 484 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.

1987 • 479 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

1991 • 440 citations

Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue

1979 • 437 citations

Plasminogen activator inhibitors: hormonally regulated serpins

1990 • 409 citations

High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis.

1993 • 396 citations

The activation of pro-urokinase by plasma kallikrein and its inactivation by thrombin.

1986 • 391 citations

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.

1990 • 374 citations

Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).

1991 • 347 citations

Growth factors in the regulation of pericellular proteolysis: a review.

1989 • 342 citations

Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.

1992 • 333 citations

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

1992 • 331 citations

Invasion of the trophoblasts

1992 • 305 citations

Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report

1988 • 294 citations

Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer.

1990 • 294 citations

Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos.

1989 • 287 citations

Messenger RNA for two type IV collagenases is located in stromal cells in human colon cancer.

1993 • 283 citations

The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.

1990 • 278 citations

A 55,000-60,000 Mr receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification.

1988 • 275 citations

In vivo invasion of modified chorioallantoic membrane by tumor cells: the role of cell surface-bound urokinase.

1988 • 273 citations

Protease nexin. Properties and a modified purification procedure.

1985 • 272 citations

The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator.

1991 • 256 citations

Type IV collagenases in invasive tumors

1993 • 256 citations

Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain.

1992 • 253 citations

Urokinase- and Tissue-Type Plasminogen Activators in Keratinocytes During Wound Reepithelialization In Vivo

1988 • 246 citations

Clinical Relevance of the Urokinase-Type and Tissue-Type Plasminogen Activators and of Their Type 1 Inhibitor in Breast Cancer

1991 • 236 citations

Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA.

1984 • 229 citations

In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion.

1991 • 216 citations

Plasminogen Activation by Receptor-Bound Urokinase

1991 • 214 citations

Cell‐induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH₂‐terminal domain of the urokinase receptor

1991 • 194 citations

Receptor for urokinase is present in tumor-associated macrophages in ductal breast carcinoma.

1993 • 192 citations

Binding of single-chain prourokinase to the urokinase receptor of human U937 cells.

1986 • 191 citations

Urokinase-type plasminogen activator (u-PA) antigen is a predictor of early relapse in breast cancer

1990 • 189 citations

Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.

1992 • 184 citations

Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse.

1991 • 179 citations

Localization of urokinase-type plasminogen activator in stromal cells in adenocarcinomas of the colon in humans.

1991 • 179 citations

Immunocytochemical localization of urokinase-type plasminogen activator in Lewis lung carcinoma.

1984 • 173 citations

Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B.

1992 • 168 citations

The Urokinase Receptor: Involvement in Cell Surface Proteolysis and Cancer Invasion

1992 • 165 citations

Differential Expression of Urokinase-Type Plasminogen Activator and Its Type-1 Inhibitor During Healing of Mouse Skin Wounds

1991 • 159 citations

Tissue-Type Plasminogen Activator

1989 • 159 citations

The plasminogen activation system in human colon cancer: messenger RNA for the inhibitor PAI-1 is located in endothelial cells in the tumor stroma.

1991 • 147 citations

Physiological mechanisms for metalloproteinase activation.

1992 • 142 citations

Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex.

1992 • 141 citations

Plasminogen-activator inhibitor type 1 is a potent natural inhibitor of extracellular matrix degradation by fibrosarcoma and colon carcinoma cells.

1990 • 131 citations

Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines.

1988 • 128 citations

Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer.

1991 • 123 citations

Expression of the stromelysin-3 gene in fibroblastic cells of invasive carcinomas of the breast and other human tissues: a review

1993 • 123 citations

Expression of Human Recombinant Plasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells

1989 • 120 citations

Urokinase-receptor biosynthesis, mRNA level and gene transcription are increased by transforming growth factor beta 1 in human A549 lung carcinoma cells.

1991 • 117 citations

Urokinase receptor mRNA level and gene transcription are strongly and rapidly increased by phorbol myristate acetate in human monocyte-like U937 cells.

1991 • 111 citations

Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract.

1991 • 110 citations

Type‐1 plasminogen activator inhibitor in human breast carcinomas

1992 • 100 citations

The receptor for urokinase‐plasminogen activator

1986 • 95 citations

Differential protease expression by cutaneous squamous and basal cell carcinomas.

1991 • 95 citations

Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells.

1989 • 95 citations

Complementation between urokinase-producing and receptor-producing cells in extracellular matrix degradation.

1991 • 87 citations

Plasminogen activators, plasminogen activator inhibitors and procoagulant analyzed in twenty human tumor cell lines

1986 • 84 citations

Plasminogen activator inhibitor-type 1 in Lewis lung carcinoma

1990 • 74 citations

The matrix metalloproteinase pump-1 catalyzes formation of low molecular weight (pro)urokinase in cultures of normal human kidney cells.

1992 • 69 citations

Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex

1992 • 64 citations

Enzyme-linked immunosorbent assay of urokinase-type plasminogen activator (uPA) in cytosolic extracts of human breast cancer tissue

1993 • 31 citations