Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Angiogenesis.

1992 • 2,581 citations

Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.

1986 • 1,408 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

Chapter 1: Interferons (IFNs)

1986 • 793 citations

Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases.

1992 • 429 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells

1988 • 352 citations

The role of matrix metalloproteases and their inhibitors in tumour invasion, metastasis and angiogenesis

1994 • 333 citations

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

1992 • 331 citations

Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary adenocarcinoma cell clones of differing metastatic potentials.

1987 • 315 citations

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

1988 • 312 citations

Matrix metalloproteinase inhibitor BB-94 (batimastat)inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

1994 • 254 citations

Inhibition of Angiogenesis and Murine Hemangioma Growth by Batimastat, a Synthetic Inhibitor of Matrix Metalloproteinases

1995 • 234 citations

Inhibition of Collagenolytic Activity and Metastasis of Tumor Cells by a Recombinant Human Tissue Inhibitor of Metalloproteinases

1990 • 233 citations

Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.

1987 • 226 citations

Suppression of the Tumorigenic and Metastatic Abilities of Murine B16-F10 Melanoma Cells In Vivo by the Overexpression of the Tissue Inhibitor of the Metalloproteinases-1

1994 • 221 citations

Inhibition of the metastatic spread and growth of B16‐BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor

1994 • 218 citations

Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression.

1993 • 209 citations

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.

1990 • 202 citations

Cathepsin B and its endogenous inhibitors: the role in tumor malignancy

1990 • 187 citations

Type IV collagenase (M(r) 72,000) expression in human prostate: benign and malignant tissue.

1993 • 181 citations

Use of a reconstituted basement membrane to measure cell invasiveness and select for highly invasive tumor cells.

1986 • 172 citations

Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide.

1994 • 141 citations

Breast-Cancer-Associated Stromelysin-3 Gene Is Expressed in Basal Cell Carcinoma and During Cutaneous Wound Healing

1992 • 127 citations

Detection and localization of mRNAs encoding matrix metalloproteinases and their tissue inhibitor in human breast pathology.

1993 • 115 citations

Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential.

1992 • 112 citations

Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor.

1995 • 109 citations

A High Throughput Fluorogenic Substrate for Interstitial Collagenase (MMP-1) and Gelatinase (MMP-9)

1993 • 103 citations

Inhibitions by E-64 Derivatives of Rat Liver Cathepsin B and Cathepsin L In Vitro and In Vivo 1

1980 • 99 citations

Synthetic substrates of vertebrate collagenase

1985 • 84 citations

Inhibition of cysteine proteinases in lysosomes and whole cells

1992 • 84 citations

Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor

1994 • 65 citations

The Effect of Lethally Irradiated Cells on the Transplantability of Murine Tumours

1973 • 63 citations

A quantitative model for the study of the growth and treatment of a tumor and its metastases with correlation between proliferative state and sensitivity to cyclophosphamide.

1972 • 52 citations

Selective inhibition of proteolytic enzymes in an in vivo mouse model for experimental metastasis.

1986 • 43 citations

Stromelysin-3 mRNA expression and malignancy: comparison with clinicopathological features and type IV collagenase mRNA expression in breast tumors.

1993 • 24 citations

Marked induction of gelatinases, especially type B, in host fibroblasts by human ovarian cancer cells in athymic mice

1995 • 21 citations

Growth support of small B16 melanoma implants with nitrosourea-sterilized fractions of the same tumor.

1976 • 10 citations