γδ T cells: an important source of IL-17

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

Interleukin-17 Family Members and Inflammation

2004 • 2,340 citations

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

2006 • 2,234 citations

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

2007 • 2,031 citations

Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

2003 • 1,828 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

2006 • 1,806 citations

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

2007 • 1,446 citations

STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells

2007 • 1,418 citations

A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

2007 • 1,359 citations

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

2003 • 1,280 citations

Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17

2005 • 895 citations

IL-17 Production Is Dominated by γδ T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection

2006 • 748 citations

Th17: the third member of the effector T cell trilogy

2007 • 642 citations

Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.

1993 • 612 citations

Microbial Lipopeptides Induce the Production of IL-17 in Th Cells

2000 • 589 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epithelia

1990 • 533 citations

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease

2008 • 523 citations

IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guérin Infection

2007 • 511 citations

Resident Vδ1+ γδ T Cells Control Early Infiltration of Neutrophils after Escherichia coli Infection via IL-17 Production

2007 • 478 citations

Transcriptional regulation of Th17 cell differentiation

2007 • 469 citations

Basophils Produce IL-4 and Accumulate in Tissues after Infection with a Th2-inducing Parasite

2004 • 430 citations

An IL-17F/A Heterodimer Protein Is Produced by Mouse Th17 Cells and Induces Airway Neutrophil Recruitment

2007 • 355 citations

The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation

2006 • 295 citations

Exacerbation of Collagen-Induced Arthritis by Oligoclonal, IL-17-Producing γδ T Cells

2007 • 290 citations

Helper T cells regulate type-2 innate immunity in vivo

2002 • 195 citations

Adverse functions of IL‐17A in experimental sepsis

2008 • 193 citations

IL-17B and IL-17C Are Associated with TNF-α Production and Contribute to the Exacerbation of Inflammatory Arthritis

2007 • 183 citations

Characterization of gamma delta T lymphocytes at the maternal-fetal interface.

1992 • 122 citations

Evidence that the same gamma delta T cells respond during infection-induced and autoimmune inflammation.

1997 • 72 citations

Involvement of IL-17 in Fas ligand-induced inflammation

2004 • 56 citations

Response of a gamma delta+ T cell receptor invariant subset during bacterial infection.

1996 • 50 citations

Inflammation alone evokes the response of a TCR-invariant mouse gamma delta T cell subset.

1999 • 49 citations

Inflammation Alone Evokes the Response of a TCR-Invariant Mouse γδ T Cell Subset

1999 • 38 citations

Modulation of experimental allergic encephalomyelitis in mice by immunization with a peptide specific for the γδ T cell receptor

1997 • 23 citations

Persistent infection with Listeria monocytogenes in the kidney induces anti‐inflammatory invariant fetal‐type γδ T cells

2001 • 19 citations