Nuclear Factor-κB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

Foxp3 in control of the regulatory T cell lineage

2007 • 690 citations

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

2005 • 583 citations

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

2007 • 567 citations

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

2008 • 501 citations

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

2003 • 458 citations

Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen

2001 • 429 citations

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

2008 • 405 citations

Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

2000 • 365 citations

Regulatory T cells – a brief history and perspective

2007 • 351 citations

DNA methylation: Bisulphite modification and analysis

2006 • 346 citations

A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

2006 • 339 citations

Antigen-Receptor Signaling to Nuclear Factor κB

2006 • 320 citations

The Role of Erk1 and Erk2 in Multiple Stages of T Cell Development

2005 • 319 citations

NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

2000 • 280 citations

The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function

2006 • 254 citations

Requirement for CARMA1 in Antigen Receptor-Induced NF-κB Activation and Lymphocyte Proliferation

2003 • 253 citations

A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells

2009 • 250 citations

Differential dependence of CD4 ⁺ CD25 ⁺ regulatory and natural killer-like T cells on signals leading to NF-κB activation

2004 • 228 citations

Calcineurin B1 Is Essential for Positive but Not Negative Selection during Thymocyte Development

2004 • 216 citations

Mature T Cells Depend on Signaling through the IKK Complex

2003 • 210 citations

The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes

2006 • 186 citations

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

2001 • 165 citations

Thymic development and peripheral homeostasis of regulatory T cells

2007 • 160 citations

STAT5 Interaction with the T Cell Receptor Complex and Stimulation of T Cell Proliferation

1999 • 132 citations

RelA Is a Potent Transcriptional Activator of the CD28 Response Element within the Interleukin 2 Promoter

1995 • 131 citations

Differential requirement of PKC-θ in the development and function of natural regulatory T cells

2008 • 129 citations

Signals from CD28 Induce Stable Epigenetic Modification of the IL-2 Promoter

2005 • 125 citations

LAT-mediated signaling in CD4+CD25+ regulatory T cell development

2005 • 121 citations

c-Rel Is Required for Chromatin Remodeling Across the IL-2 Gene Promoter

2003 • 120 citations

Differential requirement for CARMA1 in agonist‐selected T‐cell development

2009 • 65 citations

Differential Role of the Transcription Factor NF-κB in Selection and Survival of CD4+ and CD8+ Thymocytes

2008 • 54 citations

Cutting Edge: Paracrine, but Not Autocrine, IL-2 Signaling Is Sustained during Early Antiviral CD4 T Cell Response

2006 • 53 citations

Rel/NF-κB family member RelA regulates NK1.1− to NK1.1+ transition as well as IL-15-induced expansion of NKT cells

2008 • 51 citations

Stimulation of thymocytes before and after positive selection results in the induction of different NF-kappa B/Rel protein complexes.

1995 • 41 citations

Biphasic Regulation of Il2 Transcription in CD4+ T Cells: Roles for TNF-α Receptor Signaling and Chromatin Structure

2008 • 24 citations

T-bet Down-Modulation in Tolerized Th1 Effector CD4 Cells Confers a TCR-Distal Signaling Defect That Selectively Impairs IFN-γ Expression

2006 • 17 citations