Fas (CD95)-related apoptosis and rheumatoid arthritis

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

Inhibition of T cell apoptosis in the rheumatoid synovium.

1997 • 474 citations

NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

1998 • 462 citations

Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells.

1998 • 453 citations

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

2000 • 440 citations

Apoptosis in rheumatoid arthritis synovium.

1995 • 378 citations

Apoptosis as a therapeutic tool in rheumatoid arthritis

2002 • 377 citations

Evidence that anti–tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis joints: Extended report

2005 • 257 citations

Apoptosis and functional fas antigen in rheumatoid arthritis synoviocytes

1995 • 234 citations

A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis

2002 • 222 citations

Inflammatory arthritis requires Foxo3a to prevent Fas ligand–induced neutrophil apoptosis

2005 • 203 citations

Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer.

1997 • 196 citations

Chronic neutropenia mediated by Fas ligand

2000 • 160 citations

Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis

2000 • 159 citations

Fas ligation on macrophages enhances IL-1R1–Toll-like receptor 4 signaling and promotes chronic inflammation

2004 • 128 citations

Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice.

1996 • 121 citations

Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases

1999 • 120 citations

Rheumatoid arthritis synovial macrophages express the Fas-associated death domain-like interleukin-1?-converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis

2001 • 112 citations

ONCOGENES IN RHEUMATOID ARTHRITIS

1995 • 104 citations

Accumulation of soluble fas in inflamed joints of patients with rheumatoid arthritis

1997 • 104 citations

Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand.

2001 • 102 citations

Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer

1998 • 99 citations

Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia

2002 • 99 citations

Effective Treatment of Established Mouse Collagen-Induced Arthritis by Systemic Administration of Dendritic Cells Genetically Modified to Express FasL

2002 • 98 citations

Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis

1998 • 90 citations

Effective Treatment of Established Mouse Collagen-Induced Arthritis by Systemic Administration of Dendritic Cells Genetically Modified to Express FasL

2002 • 87 citations

FLICE‐inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis

2002 • 87 citations

Evaluation of a new Apo-1/Fas promoter polymorphism in rheumatoid arthritis and systemic lupus erythematosus patients

1999 • 81 citations

Inhibition of fas antigen‐mediated apoptosis of rheumatoid synovial cells in vitro by transforming growth factor β1

1996 • 80 citations

Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium

2002 • 78 citations

CD44 Is the Physiological Trigger of Fas Up-Regulation on Rheumatoid Synovial Cells

2001 • 74 citations

Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes

1998 • 70 citations

Impaired Fas Signaling Pathway Is Involved in Defective T Cell Apoptosis in Autoimmune Murine Arthritis

2001 • 69 citations

Tumor necrosis factor ? regulation of the Fas-mediated apoptosis-signaling pathway in synovial cells

1999 • 66 citations

Rheumatic diseases in an MRL strain of mice with a deficit in the functional Fas ligand

1997 • 65 citations

Down‐regulation of FLIP sensitizes rheumatoid synovial fibroblasts to Fas‐mediated apoptosis

2004 • 61 citations

Novel gene therapy for rheumatoid arthritis by FADD gene transfer: induction of apoptosis of rheumatoid synoviocytes but not chondrocytes

2000 • 60 citations

Modulation by proinflammatory cytokines of Fas/Fas ligand-mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis (RA)

1998 • 59 citations

Differential regulation of FAS-mediated apoptosis of rheumatoid synoviocytes by tumor necrosis factor α and basic fibroblast growth factor is associated with the expression of apoptosis-related molecules

2000 • 58 citations

Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis

1997 • 56 citations

TUMOUR NECROSIS FACTOR α (TNF-α) INTERFERES WITH Fas-MEDIATED APOPTOTIC CELL DEATH ON RHEUMATOID ARTHRITIS (RA) SYNOVIAL CELLS: A POSSIBLE MECHANISM OF RHEUMATOID SYNOVIAL HYPERPLASIA AND A CLINICAL BENEFIT OF ANTI-TNF-α THERAPY FOR RA

2000 • 56 citations

Potential withdrawal of rheumatoid synovium by the induction of apoptosis using a novel in vivo model of rheumatoid arthritis

1998 • 54 citations

Gene Transfer of Tissue Inhibitor of Metalloproteinases-3 Reverses the Inhibitory Effects of TNF-α on Fas-Induced Apoptosis in Rheumatoid Arthritis Synovial Fibroblasts

2005 • 53 citations

Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts

2003 • 43 citations

Selective activation of the JNK/AP‐1 pathway in FAS‐mediated apoptosis of rheumatoid arthritis synoviocytes

1997 • 42 citations

Nitric oxide protects cultured rheumatoid synovial cells from Fas‐induced apoptosis by inhibiting caspase‐3

2001 • 41 citations

Amelioration of systemic autoimmune disease by the stimulation of apoptosis-promoting receptor Fas with anti-Fas mAb

1997 • 37 citations

FAS Antigen Expression on Synovial Cells Was Down-Regulated by Interleukin 1β

1996 • 35 citations

β1 integrin–mediated signaling induces intercellular adhesion molecule 1 and Fas on rheumatoid synovial cells and Fas‐mediated apoptosis

2003 • 35 citations

Antirheumatic effects of humanized anti-Fas monoclonal antibody in human rheumatoid arthritis/SCID mouse chimera.

2003 • 34 citations

Expression of Fas ligand improves the effect of IL-4 in collagen-induced arthritis

2000 • 33 citations

Apomodulation as a novel therapeutic concept for the regulation of apoptosis in rheumatoid synoviocytes

1999 • 33 citations

T cell receptor of Fas-sensitive T cells in rheumatoid synovium.

1997 • 32 citations

Fas‐associated death domain protein is a Fas‐mediated apoptosis modulator in synoviocytes

2000 • 30 citations

Ceramide, a mediator of interleukin 1, tumour necrosis factor alpha , as well as Fas receptor signalling, induces apoptosis of rheumatoid arthritis synovial cells

1998 • 30 citations

A proinflammatory role for Fas in joints of mice with collagen-induced arthritis

2004 • 30 citations

Apoptosis induction in synovial fibroblasts by ceramide: In vitro and in vivo effects

1998 • 26 citations

The Development of Autoimmune Inflammatory Arthropathy in Mice Transgenic for the Human T Cell Leukemia Virus Type-1env-pXRegion Is Not Dependent on H-2 Haplotypes and Modified by the Expression Levels of Fas Antigen

1998 • 21 citations

Chronic neutropenia mediated by Fas ligand

2000 • 16 citations

Therapeutic effect of anti-Fas antibody on a collagen induced arthritis model.

2001 • 15 citations

CD4⁺ T‐cell‐mediated cytotoxicity against staphylococcal enterotoxin B‐pulsed synovial cells

1998 • 3 citations

A single cell analysis of Fas ligand positive T cells in rheumatoid synovial fluid.

2000 • 2 citations