A proinflammatory role for Fas in joints of mice with collagen-induced arthritis

The Fas Death Factor

1995 • 4,070 citations

Autoimmunity to type II collagen an experimental model of arthritis.

1977 • 1,599 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

1992 • 1,002 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.

1981 • 705 citations

Development of anti-TNF therapy for rheumatoid arthritis

2002 • 673 citations

Interleukin 6 Is Required for the Development of Collagen-induced Arthritis

1998 • 605 citations

Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis

1997 • 584 citations

Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: A comparative study using anti-TNFα, anti-IL-1α/β and IL-1Ra

2008 • 514 citations

The Role of Fas in Autoimmune Diabetes

1997 • 503 citations

Inhibition of T cell apoptosis in the rheumatoid synovium.

1997 • 474 citations

Apoptosis in rheumatoid arthritis synovium.

1995 • 378 citations

Anticytokine treatment of established type II collagen–induced arthritis in DBA/1 mice: A comparative study using anti‐TNFα, anti–IL‐1α/β, and IL‐1Ra

1996 • 370 citations

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

1996 • 362 citations

Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen‐induced arthritis

1996 • 317 citations

Involvement of the CD95 (APO-1/Fas) receptor/ligand system in multiple sclerosis brain.

1996 • 283 citations

Type ii collagen—induced arthritis in mice

1984 • 281 citations

Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice.

1996 • 203 citations

INTERLEUKIN-6 (IL-6) INDUCES THE PROLIFERATION OF SYNOVIAL FIBROBLASTIC CELLS IN THE PRESENCE OF SOLUBLE IL-6 RECEPTOR

1995 • 202 citations

The apoptosis-1/Fas protein in human systemic lupus erythematosus.

1994 • 200 citations

Resistance to Apoptosis and Elevated Expression of Bcl-2 in Clonally Expanded CD4+CD28− T Cells from Rheumatoid Arthritis Patients

1998 • 192 citations

Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells.

1996 • 187 citations

Apoptosis and the maintenance of homoeostasis in the immune system

1996 • 178 citations

Fas and Fas ligand enhance the pathogenesis of experimental allergic encephalomyelitis, but are not essential for immune privilege in the central nervous system.

1997 • 155 citations

Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor

1995 • 132 citations

Fas ligation on macrophages enhances IL-1R1–Toll-like receptor 4 signaling and promotes chronic inflammation

2004 • 128 citations

The Immune Regulatory Function of Lymphoproliferative Double Negative T Cells In Vitro and In Vivo

2002 • 121 citations

Conversion in vivo from an early dominant Th0/Th1 response to a Th2 phenotype during the development of collagen‐induced arthritis

1997 • 110 citations

Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis.

1995 • 108 citations

Localisation of apoptosis and expression of apoptosis related proteins in the synovium of patients with rheumatoid arthritis.

1996 • 105 citations

The cell biology of CTL killing

1995 • 99 citations

Up-regulated expression of Fas antigen (CD95) by peripheral naive and memory T cell subsets in patients with systemic lupus erythematosus (SLE): a possible mechanism for lymphopenia

1995 • 98 citations

Evidence for Fas-Dependent and Fas-Independent Mechanisms in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

1999 • 98 citations

Cytokine expression in rheumatoid arthritis.

1991 • 94 citations

Early appearance of activated CD4+ T lymphocytes and class II antigen-expressing cells in joints of DBA/1 mice immunized with type II collagen.

1988 • 93 citations

B-cell activation and development within chronically inflamed synovium in rheumatoid and reactive arthritis

1997 • 80 citations

COLLAGEN ARTHRITIS—WHAT CAN IT TEACH US?

1994 • 63 citations

Collagen autoimmunity and arthritis

1988 • 62 citations

Regulation of CD95 (Fas/APO-1)-induced apoptosis in human chondrocytes

2001 • 59 citations

Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis

1997 • 56 citations

Apoptosis in rheumatoid arthritis - expression of Fas, Fas-L, p53, and Bcl-2 in rheumatoid synovial tissues

2001 • 55 citations

T-cells in the pathogenesis of rheumatoid arthritis Villains or accomplices?

1997 • 54 citations

Rheumatoid arthritis and its animal models: the role of TNF-α and the possible absence of specific immune reactions

1999 • 53 citations

Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains

2002 • 50 citations

In situ expression of protooncogenes and Fas/Fas ligand in rheumatoid arthritis synovium.

1997 • 41 citations

Induction of Fas-dependent apoptosis in synovial infiltrating cells in rheumatoid arthritis

1996 • 36 citations

Fas (CD95)-transduced signal preferentially stimulates lupus peripheral T lymphocytes

1998 • 30 citations