Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells.

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

1986 • 1,453 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1996 • 1,001 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Efficacy of Low-Dose Methotrexate in Rheumatoid Arthritis

1985 • 861 citations

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

1997 • 749 citations

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

1993 • 658 citations

Comparison of low‐dose oral pulse methotrexate and placebo in the treatment of rheumatoid arthritis. A Controlled Clinical Trial

1985 • 462 citations

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1985 • 460 citations

Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells.

1986 • 416 citations

Acute graft-versus-host disease: analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexate [see comments]

1992 • 367 citations

Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.

1985 • 345 citations

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.

1991 • 336 citations

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

1985 • 312 citations

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

1995 • 294 citations

Cyclosporine, Methotrexate, and Prednisone Compared with Cyclosporine and Prednisone for Prophylaxis of Acute Graft-versus-Host Disease

1993 • 266 citations

Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides.

1998 • 260 citations

Anti‐immunoglobulins induce death by apoptosis in WEHI‐231 B lymphoma cells

1990 • 239 citations

Advances in Chemotherapy of Cancer in Man

1956 • 193 citations

Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

1982 • 184 citations

FK506 in combination with methotrexate for the prevention of graft- versus-host disease after marrow transplantation from matched unrelated donors

1996 • 156 citations

Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes. A potential role for the acidic sphingomyelinase pathway in normal immunoregulation.

1996 • 124 citations

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.

1983 • 105 citations

Toxicity and serum levels of methotrexate in children with juvenile rheumatoid arthritis

1989 • 103 citations

Human T cells require IL-2 but not G1/S transition to acquire susceptibility to Fas-mediated apoptosis.

1996 • 80 citations

Apoptosis without decrease of cell DNA content

1995 • 50 citations

Methotrexate pharmacokinetics in patients with rheumatoid arthritis.

1989 • 47 citations

Fas-Independent Apoptosis of Activated T Cells Induced by Antibodies to the HLA Class I α1 Domain

1997 • 44 citations

Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in plasma and bone marrow of children receiving low-dose oral methotrexate

1986 • 37 citations

METHOTREXATE AS AN ADJUNCT IN THE TREATMENT OF PERSISTENT MILD CARDIAC ALLOGRAFT REJECTION

1990 • 36 citations

In vitro cell death of activated lymphocytes in Omenn's syndrome

1997 • 26 citations

Specific hyporesponsiveness of alloreactive peripheral T cells induced by CD4 antibodies

1995 • 17 citations

A Noncomitogenic CD2R Monoclonal Antibody Induces Apoptosis of Activated T Cells by a CD95/CD95-L-Dependent Pathway

1998 • 13 citations

Adenosine and Host Defense

1990 • 9 citations