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Down‐regulation of FLIP sensitizes rheumatoid synovial fibroblasts to Fas‐mediated apoptosis

Data up to Jan 2025

Published2004
Citations61
References41

Total Citations Per Year

Abstract

References (41)

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Revised Criteria for the Classification of Rheumatoid Arthritis

1990 • 7,730 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

NF-κB Signals Induce the Expression of c-FLIP

2001 • 799 citations

NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling

2001 • 583 citations

c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

2002 • 565 citations

The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways

2000 • 556 citations

FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis

2001 • 550 citations

Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development

2000 • 509 citations

Membrane Fas Ligand Kills Human Peripheral Blood T Lymphocytes, and Soluble Fas Ligand Blocks the Killing

1997 • 503 citations

NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

1998 • 462 citations

Apoptosis in rheumatoid arthritis synovium.

1995 • 378 citations

Apoptosis and functional fas antigen in rheumatoid arthritis synoviocytes

1995 • 234 citations

Flice-Inhibitory Protein Expression during Macrophage Differentiation Confers Resistance to FAS-Mediated Apoptosis

1999 • 229 citations

Localization of tumor necrosis factor receptors in the synovial tissue and cartilage‐pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor α

1992 • 216 citations

Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression.

2000 • 206 citations

Local Proliferation of Fibroblast‐Like Synoviocytes Contributes to Synovial Hyperplasia

1994 • 201 citations

Apoptosis in rheumatoid arthritis

1999 • 197 citations

Non-apoptotic Fas signaling

2002 • 191 citations

Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis

2000 • 159 citations

Death receptors couple to both cell proliferation and apoptosis

2002 • 139 citations

Ultrastructural demonstration of apoptosis, Fas and Bcl-2 expression of rheumatoid synovial fibroblasts.

1996 • 138 citations

Death receptors couple to both cell proliferation and apoptosis

2002 • 127 citations

Bcl-2 Expression in Synovial Fibroblasts Is Essential for Maintaining Mitochondrial Homeostasis and Cell Viability

2000 • 122 citations

Proliferative activity of cells in the synovium as demonstrated by a monoclonal antibody, Ki67

1987 • 114 citations

Expression of c-FLIPL and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide

2000 • 112 citations

Rheumatoid arthritis synovial macrophages express the Fas-associated death domain-like interleukin-1?-converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis

2001 • 112 citations

TRAIL-R2 (DR5) Mediates Apoptosis of Synovial Fibroblasts in Rheumatoid Arthritis

2003 • 111 citations

Gene therapy that inhibits nuclear translocation of nuclear factor κB results in tumor necrosis factor α–induced apoptosis of human synovial fibroblasts

2000 • 104 citations

Expression of c-FLIPL and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide

2000 • 95 citations

Non-apoptotic Signaling Pathways Activated by Soluble Fas Ligand in Serum-starved Human Fibroblasts

2001 • 93 citations

FLICE‐inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis

2002 • 87 citations

Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium

2002 • 78 citations

Expression of Fas Antigen and Fas Ligand in the Rheumatoid Synovial Tissue

1996 • 73 citations

Differential regulation of FAS-mediated apoptosis of rheumatoid synoviocytes by tumor necrosis factor α and basic fibroblast growth factor is associated with the expression of apoptosis-related molecules

2000 • 58 citations

Intracellular Regulation of Fas-Induced Apoptosis in Human Fibroblasts by Extracellular Factors and Cycloheximide

2004 • 57 citations

Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts

2003 • 43 citations

Fas‐associated death domain protein is a Fas‐mediated apoptosis modulator in synoviocytes

2000 • 30 citations

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Down‐regulation of FLIP sensitizes rheumatoid synovial fibroblasts to Fas‐mediated… (2004) – Arthritis & Rheumatism | Metascience Observatory Explorer