The Development of Autoimmune Inflammatory Arthropathy in Mice Transgenic for the Human T Cell Leukemia Virus Type-1env-pXRegion Is Not Dependent on H-2 Haplotypes and Modified by the Expression Levels of Fas Antigen

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The Fas Death Factor

1995 • 4,070 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis

1990 • 963 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

1988 • 838 citations

Cloning and expression of murine interleukin-1 cDNA in Escherichia coli

1984 • 820 citations

Negative selection of lymphocytes

1994 • 810 citations

Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.

1981 • 705 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

1993 • 506 citations

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering

1987 • 438 citations

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

1987 • 413 citations

HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.

1989 • 376 citations

c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

1988 • 361 citations

Induction of Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Mice Transgenic for HTLV-I

1991 • 344 citations

Type ii collagen—induced arthritis in mice

1984 • 281 citations

The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens.

1983 • 280 citations

Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts.

1991 • 263 citations

Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.

1983 • 245 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia.

1990 • 229 citations

Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritis

1976 • 205 citations

Polymorphism of murine Fas ligand that affects the biological activity

1997 • 201 citations

Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis

1989 • 190 citations

T-Cell Activation Signals and Human T-Cell Leukemia Virus Type I-Encoded p40^x Protein Activate the Mouse Granulocyte-Macrophage Colony-Stimulating Factor Gene Through a Common DNA Element

1988 • 171 citations

Cloning of two members of the SIRPα family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells

1998 • 152 citations

Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: An in vivo approach to investigate la gene function

1987 • 134 citations

Autoimmunity induction by human T cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans.

1995 • 117 citations

Incidence of serum antibodies to native type I and type II collagens in patients with inflammatory arthritis.

1980 • 91 citations

Immune response of HLA-DQ8 transgenic mice to peptides from the third hypervariable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis.

1996 • 87 citations

trans activation of granulocyte-macrophage colony-stimulating factor and the interleukin-2 receptor in transgenic mice carrying the human T-lymphotropic virus type 1 tax gene.

1989 • 80 citations

HTLV-1 tax: regulation of gene expression and disease

1993 • 73 citations

Pathogenetic concepts and origins of rheumatoid factor in rheumatoid arthritis

1993 • 70 citations

Protective role of major histocompatibility complex class II Ebd transgene on collagen-induced arthritis.

1994 • 65 citations

Resistance to Fas-mediated Apoptosis of Peripheral T Cells in Human T Lymphocyte Virus Type I (HTLV-I) Transgenic Mice with Autoimmune Arthropathy

1997 • 63 citations

Human Retroviruses: HTLV-I and HTLV-II

1993 • 49 citations

HLA Class II Polymorphism: Implications for Genetic Susceptibility to Autoimmune Disease

1990 • 46 citations

Inflammatory polyarthritis in mice transgenic for human t cell leukemia virus type i

1993 • 45 citations

In vivo administration of interleukin‐2 turns on anergic self‐reactive T cells and leads to autoimmune disease

1992 • 44 citations

Human T lymphotropic virus type I in arthropathy and autoimmune disorders

1996 • 42 citations

Collagen-induced arthritis in T cell receptor V beta congenic B10.Q mice.

1994 • 34 citations

Multiple cytokine activities and loss of interleukin 2 inhibitor in synovial fluids of patients with rheumatoid arthritis.

1988 • 31 citations

Administration of recombinant human IL-1 by Staphylococcus enterotoxin B prevents tolerance induction in vivo.

1995 • 21 citations

Involvement of autoimmunity against type II collagen in the development of arthritis in mice transgenic for the human T cell leukemia virus type Itax gene

1999 • 21 citations

Augmentation of c-fos and c-jun expression in transgenic mice carrying the human T-cell leukemia virus type-Itax gene

1995 • 17 citations

Structural-Changes in the N-Linked Sugar Chains of Serum Immunoglobulin G of HTLV-I Transgenic Mice

1993 • 14 citations