Ontogeny and Regulation of IL-7-Expressing Thymic Epithelial Cells

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Fate of the mammalian cardiac neural crest

2000 • 1,123 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis

1988 • 845 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

Thymopoiesis independent of common lymphoid progenitors

2003 • 548 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Interleukin-7: from bench to clinic

2002 • 496 citations

Lymphostromal interactions in thymic development and function

2001 • 461 citations

The thymic microenvironment

1993 • 459 citations

Two Genetically Separable Steps in the Differentiation of Thymic Epithelium

1996 • 447 citations

The role of Hoxa-3 in mouse thymus and thyroid development

1995 • 421 citations

Heterogeneity among DN1 Prothymocytes Reveals Multiple Progenitors with Different Capacities to Generate T Cell and Non-T Cell Lineages

2004 • 417 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Mapping Precursor Movement through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development

2001 • 394 citations

Cytokines and immunodeficiency diseases

2001 • 380 citations

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1993 • 359 citations

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

1995 • 295 citations

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells

2002 • 290 citations

Identification and Characterization of Thymic Epithelial Progenitor Cells

2002 • 269 citations

Characterization and Developmental Expression of Pax9, a Paired-Box-Containing Gene Related to Pax1

1995 • 263 citations

The Fetal Liver Counterpart of Adult Common Lymphoid Progenitors Gives Rise to All Lymphoid Lineages, CD45+CD4+CD3− Cells, As Well As Macrophages

2001 • 240 citations

Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch

2001 • 237 citations

The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

1996 • 225 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets

2000 • 219 citations

Isolation and characterization of mammalian homologs of the Drosophila gene glial cells missing

1998 • 201 citations

Cutting Edge: Thymocyte-Independent and Thymocyte-Dependent Phases of Epithelial Patterning in the Fetal Thymus

2002 • 195 citations

Dissecting NK cell development using a novel alymphoid mouse model: investigating the role of the c-abl proto-oncogene in murine NK cell differentiation.

1999 • 186 citations

Different gamma delta T-cell receptors are expressed on thymocytes at different stages of development.

1989 • 183 citations

The IL-7 Receptor Controls the Accessibility of the TCRγ Locus by Stat5 and Histone Acetylation

2001 • 176 citations

Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction.

1991 • 175 citations

T Cell Progenitors Emerge Earlier Than B Cell Progenitors in the Murine Fetal Liver

2000 • 164 citations

Dissecting NK Cell Development Using a Novel Alymphoid Mouse Model: Investigating the Role of the c-abl Proto-Oncogene in Murine NK Cell Differentiation

1999 • 163 citations

Hoxa3 and Pax1 Regulate Epithelial Cell Death and Proliferation during Thymus and Parathyroid Organogenesis

2001 • 151 citations

Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction

1993 • 138 citations

In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8+ T Cells

2003 • 137 citations

Induction of TCR Gene Rearrangements in Uncommitted Stem Cells by a Subset of IL-7 Producing, MHC Class II–Expressing Thymic Stromal Cells

1997 • 119 citations

Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled.

1987 • 112 citations

Interleukin‐7 expression during mouse thymus development

1992 • 112 citations

Role of thymic organ structure and stromal composition in steady‐state postnatal T‐cell production

2002 • 99 citations

Bax Deficiency Partially Corrects Interleukin-7 Receptor α Deficiency

2002 • 95 citations

Stromal Cells Provide the Matrix for Migration of Early Lymphoid Progenitors Through the Thymic Cortex

2002 • 91 citations

A developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from?

2003 • 89 citations

Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes

1994 • 79 citations

A dose effect of IL-7 on thymocyte development

2004 • 78 citations

An Essential Role for the IL-7 Receptor During Intrathymic Expansion of the Positively Selected Neonatal T Cell Repertoire

2000 • 73 citations

Lymphoid precursors

2000 • 67 citations

Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection

2002 • 64 citations

Death and Baxes: mechanisms of lymphotrophic cytokines

2003 • 64 citations

Transgenic Expression of Cyclin D1 in Thymic Epithelial Precursors Promotes Epithelial and T Cell Development

2000 • 62 citations

Identification of the earliest prethymic T-cell progenitors in murine fetal blood

2003 • 55 citations

Pre‐TCR signaling regulates IL‐7 receptor α expression promoting thymocyte survival at the transition from the double‐negative to double‐positive stage

2003 • 54 citations

Cutting Edge: Histone Acetylation and Recombination at the TCRγ Locus Follows IL-7 Induction

2001 • 54 citations

IL-7 activates alpha4beta1 integrin in murine thymocytes.

1997 • 50 citations

Distinct roles of the interleukin-7 receptor α chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor α-deficient mice

1998 • 50 citations

Studies on thymic epithelial cells in vitro

1998 • 47 citations

Studies on the role of IL-7 presentation by mesenchymal fibroblasts during early thymocyte development

2000 • 46 citations

Thymic and intestinal intraepithelial T lymphocyte development are each regulated by the c-dependent cytokines IL-2, IL-7, and IL-15

2000 • 41 citations

Studies on the phenotype of migrant thymic stem cells

1999 • 41 citations

Control of T Cell Development In Vivo by Subdomains Within the IL-7 Receptor α-Chain Cytoplasmic Tail

2001 • 38 citations

Distinct Requirements for IL-7 in Development of TCRγδ Cells During Fetal and Adult Life

2003 • 33 citations

Studies on the role of IL-7 presentation by mesenchymal fibroblasts during early thymocyte development

2000 • 2 citations