The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

The nerve growth factor: thirty-five years later.

1987 • 720 citations

Characterization and isolation of proteolytically modified nerve growth factor

1976 • 677 citations

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

1989 • 470 citations

Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line

1977 • 395 citations

A rat brain na+ channel α subunit with novel gating properties

1988 • 359 citations

Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development.

1989 • 356 citations

The sodium channel from rat brain. Purification and subunit composition.

1984 • 352 citations

Primary structure of rat brain sodium channel III deduced from the cDNA sequence

1988 • 334 citations

Regulation of the differentiation of PC12 pheochromocytoma cells.

1989 • 296 citations

Neuron-specific expression of the rat brain type II sodium channel gene is directed by upstream regulatory elements

1990 • 227 citations

Biosynthesis and processing of the α subunit of the voltage-sensitive sodium channel in rat brain neurons

1986 • 208 citations

Differential effects of NGF, FGF, EGF, cAMP, and dexamethasone on neurite outgrowth and sodium channel expression in PC12 cells

1990 • 181 citations

Tissue-specific expression of the RI and RII sodium channel subtypes.

1987 • 171 citations

Selective phosphorylation of the alpha subunit of the sodium channel by cAMP-dependent protein kinase.

1982 • 168 citations

The saxitoxin receptor of the sodium channel from rat brain. Evidence for two nonidentical beta subunits.

1982 • 163 citations

Functional expression of cloned cDNA encoding sodium channel III

1988 • 160 citations

NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells

1989 • 140 citations

Probing the Molecular Structure of the Voltage-Dependent Sodium Channel

1988 • 140 citations

Selective induction of brain type II Na+ channels by nerve growth factor.

1988 • 139 citations

A large intracellular pool of inactive Na channel alpha subunits in developing rat brain.

1985 • 137 citations

Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms.

1990 • 121 citations

Nerve growth factor acts through cAMP-dependent protein kinase to increase the number of sodium channels in PC12 cells

1990 • 120 citations

Clonal variants of PC12 pheochromocytoma cells with defects in cAMP-dependent protein kinases induce ornithine decarboxylase in response to nerve growth factor but not to adenosine agonists.

1985 • 113 citations

Regulation of ionic currents in pheochromocytoma cells by nerve growth factor and dexamethasone

1989 • 110 citations

Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent protein kinase activities

1991 • 106 citations

Identification of an intracellular domain of the sodium channel having multiple cAMP-dependent phosphorylation sites.

1987 • 106 citations

Cyclic-AMP-dependent phosphorylation of voltage-sensitive sodium channels in primary cultures of rat brain neurons.

1987 • 105 citations

Molecular Diversity of Voltage-Sensitive Na Channels

1989 • 96 citations

The Fibroblast Growth Factors: An Emerging Family of Neural Growth Factors

1991 • 96 citations

Expression and Characterization of Mutant Forms of the Type I Regulatory Subunit of cAMP-dependent Protein Kinase

1989 • 78 citations

Developmental Regulation of Sodium Channel Expression in the Rat Forebrain

1989 • 75 citations

Nerve growth factor-induced increase in saxitoxin binding to rat PC12 pheochromocytoma cells

1982 • 75 citations

Efficiency of acetylcholine receptor subunit assembly and its regulation by cAMP.

1991 • 74 citations

Tissue Localization of Nerve Growth Factor and Nerve Growth Factor Receptors

1991 • 63 citations

Sodium channel expression and assembly during development of retinal ganglion cells

1988 • 59 citations

NGF-induction of the metalloproteinase-transin/stromelysin in PC12 cells: involvement of multiple protein kinases.

1991 • 48 citations

Regulation of sodium currents and acetylcholine responses in PC12 cells

1990 • 38 citations

Nerve Growth Factor‐Induced Down‐Regulation of Calmodulin‐Dependent Protein Kinase III in PC12 Cells Involves Cyclic AMP‐Dependent Protein Kinase

1990 • 37 citations

Nerve Growth Factor Function in the Central Nervous System

1991 • 36 citations

Trophic Factors in Neurologic Disease

1988 • 34 citations

Clonal Variants of PC12 Pheochromocytoma Cells with Defects in cAMP-Dependent Protein Kinases Induce Ornithine Decarboxylase in Response to Nerve Growth Factor but not to Adenosine Agonists

1985 • 27 citations

Regulation of neural cell survival and differentiation by peptide growth factors

1990 • 26 citations

Voltage-sensitive Na+ channels: motifs, modes and modulation

1991 • 20 citations

Identification and partial purification of fibroblast growth factor from the brains of developing rats and leucodystrophic mutant mice

1985 • 19 citations