Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)

1983 • 2,305 citations

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

1979 • 2,285 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

The induction of differentiation in teratocarcinoma stem cells by retinoic acid

1978 • 1,459 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS

1967 • 1,116 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

1986 • 1,063 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Identification of a second human retinoic acid receptor

1988 • 1,049 citations

Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth Factor

1986 • 1,032 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions

1949 • 974 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death

1987 • 942 citations

Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.

1985 • 941 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells.

1982 • 791 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

The Coupling of Neurotransmitter Receptors to Ion Channels in the Brain

1988 • 732 citations

NGF-Mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?

1983 • 725 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

Transforming growth factor α

1988 • 707 citations

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease

1981 • 698 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain

1986 • 659 citations

Cell death in the development of the lateral motor column of the chick embryo

1975 • 658 citations

Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons

1988 • 657 citations

Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma

1985 • 644 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

Cholinergic function and intellectual decline in Alzheimer's disease

1986 • 605 citations

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

1986 • 604 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat

1984 • 598 citations

Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation.

1983 • 564 citations

The physiological function of nerve growth factor in the central nervous system: Comparison with the periphery

1987 • 558 citations

Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

1987 • 555 citations

Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding properties

1988 • 539 citations

Pedunculopontine tegmental nucleus of the rat: Cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum

1987 • 537 citations

Bioerodible polyanhydrides as drug‐carrier matrices. I: Characterization, degradation, and release characteristics

1985 • 532 citations

Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy.

1987 • 532 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons.

1986 • 528 citations

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.

1986 • 525 citations

Neuronal Chemotaxis: Chick Dorsal-Root Axons Turn Toward High Concentrations of Nerve Growth Factor

1979 • 522 citations

Purification of the Chick Eye Ciliary Neuronotrophic Factor

1984 • 519 citations

Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs.

1984 • 519 citations

Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells

1986 • 519 citations

Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression

1988 • 508 citations

Dorsal Root Ganglion Neurons Are Destroyed by Exposure in Utero to Maternal Antibody to Nerve Growth Factor

1980 • 500 citations

Thyroid Hormones and Brain Development

1987 • 497 citations

The expression, localization and functional significance of β-nerve growth factor in the central nervous system

1987 • 496 citations

Monomeric insulins obtained by protein engineering and their medical implications

1988 • 493 citations

Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons

1985 • 491 citations

Brain-derived neurotrophic factor prevents neuronal death in vivo

1988 • 490 citations

Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor

1985 • 483 citations

Differential expression of insulin-like growth factor genes in rat central nervous system.

1988 • 477 citations

Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cells

1986 • 472 citations

Gene Transfer and Molecular Cloning of the Human NGF Receptor

1986 • 447 citations

Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions

1984 • 446 citations

Nerve Growth Factor Gene Expression in the Developing Rat Brain

1986 • 436 citations

Adhesion molecules and the hierarchy of neural development

1988 • 431 citations

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

1986 • 426 citations

Nerve growth factor (NGF) in the rat CNS: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra

1979 • 422 citations

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

1986 • 416 citations

In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor

1988 • 408 citations

Distribution of neuronal receptors for nerve growth factor in the rat

1986 • 398 citations

Retinoic Acid-Induced Growth Inhibition and Morphologic Differentiation of Human Neuroblastoma Cells In Vitro<xref ref-type="fn" rid="fn2">2</xref>

1982 • 384 citations

Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development.

1986 • 383 citations

Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds

1988 • 382 citations

Nerve growth factor and Alzheimer's disease

1986 • 378 citations

Purification and characterization of a neurite extension factor from bovine brain.

1985 • 378 citations

Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons

1986 • 377 citations

Fibroblast growth factor

1986 • 367 citations

Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues.

1984 • 359 citations

Expression of the β-Nerve Growth Factor Gene in Hippocampal Neurons

1988 • 356 citations

Neurochemical Studies of Early-Onset Alzheimer's Disease

1985 • 356 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

New Perspectives on Alzheimer's Disease

1986 • 349 citations

Cellular localization of nerve growth factor synthesis by in situ hybridization.

1987 • 345 citations

Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

1988 • 343 citations

Molecular Characterization of Fibroblast Growth Factor: Distribution and Biological Activities in Various Tissues

1986 • 340 citations

Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

1986 • 340 citations

Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro

1987 • 336 citations

Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease

1986 • 335 citations

Insulin and insulin-like growth factors in the CNS

1988 • 334 citations

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase

1983 • 332 citations

The Biology and Mechanism of Action of Nerve Growth Factor

1982 • 324 citations

Morphological response of axotomized septal neurons to nerve growth factor

1988 • 323 citations

Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes

1988 • 321 citations

Receptor- and heparin-binding domains of basic fibroblast growth factor.

1988 • 318 citations

Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury

1987 • 316 citations

STUDIES OF THE CONNEXIONS OF THE FORNIX SYSTEM

1954 • 312 citations

Rat β‐nerve growth factor sequence and site of synthesis in the adult hippocampus

1988 • 309 citations

Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor

1987 • 297 citations

A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins

1986 • 297 citations

Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures

1982 • 291 citations

Developmental Neurobiology and the Natural History of Nerve Growth Factor

1982 • 289 citations

Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain

1986 • 289 citations

Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia

1987 • 285 citations

Cholinergic systems in mammalian brain identified with antibodies against choline acetyltransferase

1984 • 285 citations

Thyroid Hormones and Brain Development

1977 • 279 citations

The brain fibroblast growth factor (FGF) is localized in neurons

1986 • 276 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system

1987 • 268 citations

Epidermal Growth Factor Immunoreactive Material in the Central Nervous System: Location and Development

1984 • 266 citations

HYPOTHESES CONCERNED WITH AXONAL REGENERATION IN THE MAMMALIAN NERVOUS SYSTEM

1979 • 264 citations

A glia-derived neurite-promoting factor with protease inhibitory activity.

1985 • 263 citations

Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.

1988 • 262 citations

Bioerodible polyanhydrides as drug‐carrier matrices. II. Biocompatibility and chemical reactivity

1986 • 258 citations

Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: Response to fimbria‐fornix transection

1989 • 255 citations

Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease

1988 • 254 citations

Purification of adult rat sciatic nerve ciliary neuronotrophic factor

1986 • 253 citations

Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development

1988 • 252 citations

Expression of NGF receptor in the developing and adult primate central nervous system

1988 • 251 citations

The response of chick sensory neurons to brain-derived neurotrophic factor

1986 • 251 citations

An anatomical study of the development of the septo-hippocampal projection in the rat

1983 • 251 citations

Type-2 astrocyte development in rat brain cultures is initiated by a CNTF like protein produced by type-1 astrocytes

1988 • 249 citations

Developmental and regional expression of β-nerve growth factor receptor mRNA in the chick and rat

1988 • 245 citations

NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum

1989 • 241 citations

Nerve growth factor promotes human hemopoietic colony growth and differentiation.

1988 • 241 citations

Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts.

1988 • 239 citations

Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain

1987 • 237 citations

Retrograde cell changes in medial septum and diagonal band following fimbria-fornix transection: Quantitative temporal analysis

1986 • 235 citations

The role of NGF in sensory neurons in vivo

1986 • 233 citations

Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage

1988 • 233 citations

Neurotrophic Factors

1985 • 230 citations

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

1983 • 230 citations

Glia-Induced Morphological Differentiation in Neuroblastoma Cells

1973 • 228 citations

Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism

1986 • 224 citations

Specificity of retrograde transport of nerve growth factor (NGF) in sensory neurons: A biochemical and morphological study

1975 • 221 citations

Experimental autoimmune model of nerve growth factor deprivation: Effects on developing peripheral sympathetic and sensory neurons

1979 • 220 citations

Reduction of Naturally Occurring Motoneuron Death in Vivo by a Target-Derived Neurotrophic Factor

1988 • 213 citations

Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment

1988 • 213 citations

Developmental change in the nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats

1988 • 208 citations

Grafting genetically modified cells to the brain: Possibilities for the future

1987 • 206 citations

Insulin-like growth factor II (IGF II) in human brain: regional distribution of IGF II and of higher molecular mass forms.

1985 • 205 citations

Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat.

1988 • 200 citations

Some characteristics of histamine secretion from rat peritoneal mast cells stimulated with nerve growth factor.

1986 • 199 citations

Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.

1984 • 197 citations

Retrograde changes in cholinergic neurons in the basal forebrain of the rat following cortical damage

1983 • 197 citations

Quantitative demonstration of the retrograde axonal transport of endogenous nerve growth factor

1983 • 195 citations

Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain.

1985 • 195 citations

Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence

1987 • 194 citations

Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain

1988 • 189 citations

Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content

1986 • 188 citations

In vivo effect of brain-derived neurotrophic factor on the survival of developing dorsal root ganglion cells.

1987 • 187 citations

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

1988 • 186 citations

Insulin-Mediated Regulation of Neuronal Maturation

1984 • 184 citations

Loss of pedunculopontine neurons in progressive supranuclear palsy

1987 • 184 citations

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

1987 • 180 citations

Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography

1988 • 179 citations

Is Alzheimer disease caused by lack of nerve growth factor?

1983 • 178 citations

Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): Distribution, morphology, and colocalization with cholinergic enzymes

1988 • 176 citations

Characterization of the binding properties and retrograde axonal transport of a monoclonal antibody directed against the rat nerve growth factor receptor.

1985 • 175 citations

Potential use of nerve growth factor to treat Alzheimer's disease

1989 • 174 citations

Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation.

1985 • 174 citations

Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions

1985 • 172 citations

Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease

1989 • 168 citations

Nerve Growth Factor: Biological Significance, Measurement and Distribution

1980 • 163 citations

Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs

1982 • 163 citations

The cholinergic nuclei of the basal forebrain of the rat: normal structure, development and experimentally induced degeneration

1987 • 161 citations

Senile plaques as aberrant sprout-stimulating structures

1986 • 161 citations

A single Mr approximately 103,000 125I-beta-nerve growth factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptor.

1986 • 159 citations

Developmentally regulated expression of the nerve growth factor receptor gene in the periphery and brain.

1987 • 157 citations

Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick spinal motor neurons in culture

1986 • 157 citations

Neurotrophic effects of basic and acidic fibroblast growth factors are not mediated through glial cells

1988 • 156 citations

Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury

1988 • 153 citations

Stabilizing basic fibroblast growth factor using protein engineering

1988 • 153 citations

Developmental changes of nerve growth factor and its mRNA in the rat hippocampus: Comparison with choline acetyltransferase

1987 • 152 citations

Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury

1984 • 152 citations

Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: Assessment of potential neurotrophic effects

1988 • 151 citations

Basic fibroblast growth factor and epidermal growth factor exert differential trophic effects on CNS neurons

1988 • 149 citations

Experimental approaches to age-related cognitive impairments

1988 • 149 citations

The effect of platelet-derived growth factor on morphology and motility of human glial cells

1983 • 148 citations

Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo

1988 • 142 citations

Choline acetyltransferase activity of spinal cord cell cultures increased by co-culture with muscle and by muscle-conditioned medium

1977 • 141 citations

Insulin-like growth factor I in cultured rat astrocytes: expression of the gene, and receptor tyrosine kinase.

1987 • 141 citations

Neurite outgrowth from embryonic chicken spinal neurons is promoted by media conditioned by muscle cells.

1981 • 141 citations

Sympathetic sprouting in the central nervous system: a model for studies of axonal growth in the mature mammalian brain

1987 • 139 citations

Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: I. Effects of cell density and of an adult mammalian striatal-derived neuronotrophic factor (SDNF)

1988 • 134 citations

Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor.

1987 • 134 citations

Extracts of Skeletal Muscle Increase Neurite Outgrowth and Cholinergic Activity of Fetal Rat Spinal Motor Neurons

1983 • 134 citations

Transient expression of NGF-receptor-like immunoreactivity in postnatal rat brain and spinal cord

1988 • 134 citations

Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region.

1984 • 133 citations

Characterization of a neuronal subtype of insulin-like growth factor I receptor.

1987 • 132 citations

Production of insulin‐like growth factors and their carrier by rat pituitary gland and brain explants in culture

1981 • 132 citations

Characterization of a thyroid hormone receptor expressed in human kidney and other tissues.

1988 • 132 citations

Neurite outgrowth induced by an endothelial cell mitogen isolated from retina.

1986 • 131 citations

A thyromimetic that decreases plasma cholesterol levels without increasing cardiac activity

1986 • 129 citations

Age-related loss of nerve growth factor sensitivity in rat basal forebrain neurons

1988 • 128 citations

Developing dorsal root ganglion neurons require trophic support from their central processes: evidence for a role of retrogradely transported nerve growth factor from the central nervous system to the periphery.

1984 • 125 citations

Soluble striatal extracts enhance development of mesencephalic dopaminergic neurons in vitro

1986 • 124 citations

A Glia-Derived Nexin Promotes Neurite Outgrowth in Cultured Chick Sympathetic Neurons

1988 • 122 citations

Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro

1988 • 122 citations

NGF effects on developing forebrain cholinergic neurons are regionally specific

1987 • 120 citations

cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily

1987 • 119 citations

Triiodothyronine enhancement of neuronal differentiation in aggregating fetal rat brain cells cultured in a chemically defined medium

1980 • 118 citations

Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases.

1987 • 117 citations

Nerve growth factor selectively increases cholinergic markers but not neuropeptides in rat basal forebrain in culture

1987 • 113 citations

Nerve growth factor mRNA in brain: Localization by in situ hybridization

1986 • 110 citations

Changes in insulin and transferrin requirements of pure brain neuronal cultures during embryonic development.

1986 • 109 citations

Detection of glia-derived nexin in the olfactory system of the rat

1988 • 108 citations

What, if anything, is a neurotrophic factor?

1988 • 108 citations

Characterization of somatomedin/insulin-like growth factor receptors and correlation with biologic action in cultured neonatal rat astroglial cells

1987 • 107 citations

Insulin and insulinlike growth factor receptors regulating neurite formation in cultured human neuroblastoma cells

1988 • 106 citations

Epidermal growth factor receptor immunoreactivity in rat brain astrocytes. Response to injury

1988 • 106 citations

A study of the de- and regenerative changes in the sympathetic nervous system of the adult mouse after treatment with the antiserum to nerve growth factor

1975 • 96 citations

Chapter 15 Brain derived neurotrophic factor

1987 • 94 citations

Biochemical effects of antibodies against nerve growth factor on developing and differentiated sympathetic ganglia

1978 • 94 citations

Early release of glia maturation factor and acidic fibroblast growth factor after rat brain injury

1988 • 94 citations

Specific influence of striatal target neurons on the in vitro outgrowth of mesencephalic dopaminergic neurites: a morphological quantitative study

1983 • 93 citations

Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse

1975 • 91 citations

Natural and synthetic forms of insulin-like growth factor-1 (IGF-1) and the potent derivative, destripeptide IGF-1: Biological activities and receptor binding

1987 • 90 citations

Effect of retinoic acid on nerve growth factor receptors

1987 • 90 citations

Insulin and somatemedin MSA promote nerve growth factor‐independent neurite formation by cultured chick dorsal root ganglionic sensory neurons

1982 • 89 citations

Cholinergic System in Behavior: The Search for Mechanisms of Action

1982 • 89 citations

Selective effects of skeletal muscle extract fractions on motoneuron development in vitro

1986 • 87 citations

Nerve growth factor as a paradigm for other polypeptide growth factors

1986 • 87 citations

Induction of neural-like cells and acetylcholinesterase activity in cultures of F9 teratocarcinoma treated with retinoic acid and dibutyryl cyclic adenosine monophosphate

1980 • 87 citations

Expression of nerve growth factor receptor in human peripheral neuropathies

1988 • 86 citations

Molecular Cloning and Expression of Two Forms of Human Protease Nexin I

1988 • 82 citations

A cell-free plant extract for accurate pre-tRNA processing, splicing and modification.

1987 • 82 citations

Receptors for nerve growth factor on rat spleen mononuclear cells

1987 • 81 citations

Effect of proteases and their inhibitors on neurite outgrowth from neonatal mouse sensory ganglia in culture

1986 • 80 citations

Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-I

1987 • 80 citations

Nerve growth factor promotes development of the rat septo-hippocampal cholinergic projection in vitro

1987 • 80 citations

Ultrastructural localization of fibroblast growth factor in neurons of rat brain

1987 • 77 citations

The trophic theory of neural concentrations

1986 • 77 citations

The effect of nerve growth factor and its antibody on mast cells in vivo

1988 • 76 citations

Differentiating effects of murine nerve growth factor in the peripheral and central nervous systems of Xenopus laevis tadpoles.

1985 • 76 citations

Purification and characterization of the human brain insulin receptor.

1986 • 76 citations

Long-term effects of nerve growth factor and neural transplants on behavior of rats with medial septal lesions

1986 • 76 citations

Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor

1986 • 75 citations

Purification of a skeletal muscle polypeptide which stimulates choline acetyltransferase activity in cultured spinal cord neurons.

1988 • 75 citations

An interaction between thyroid hormone and nerve growth factor in the regulation of choline acetyltransferase activity in neuronal cultures, derived from the septal-diagonal band region of the embryonic rat brain

1987 • 73 citations

Sympathetic noradrenergic sprouting in response to central cholinergic denervation

1981 • 72 citations

Intrahippocampal injections of antiserum to nerve growth factor inhibit sympathohippocampal sprouting

1985 • 72 citations

Alzheimer’s and Parkinson’s Disease

1986 • 67 citations

Insulin receptors in the brain: Structural and physiological characterization

1988 • 67 citations

Comparison between the time course of changes in nerve growth factor protein levels and those of its messenger RNA in the cultured rat iris.

1986 • 67 citations

Structural and functional analysis of the promoter region of the nerve growth factor gene

1988 • 66 citations

Insulin stimulates choline acetyltransferase activity in cultured embryonic chicken retina neurons.

1987 • 65 citations

Binding of nerve growth factor to its receptor

1987 • 65 citations

Interleukin-2-like activity in injured rat brain

1987 • 64 citations

Functional Properties of the Subtype of Insulin Receptor Found on Neurons

1988 • 64 citations

Growth factors in biology and medicine

1986 • 64 citations

Purification of basic FGF receptors from rat brain

1988 • 63 citations

Comparison of the morphological effects of acidic and basic fibroblast growth factors on rat astroblasts in culture

1988 • 63 citations

Failure of nerve growth factor to affect fetal mouse brain stem catecholaminergic neurons in culture

1980 • 62 citations

Alzheimer plaques and cortical cholinergic innervation

1986 • 62 citations

Trophic effects of skeletal muscle extracts on ventral spinal cord neurons in vitro: separation of a protein with morphologic activity from proteins with cholinergic activity.

1985 • 59 citations

Evaluation of the effects of nerve growth factor and anti-nerve growth factor on the development of central catecholamine-containing neurons

1978 • 59 citations

Effects of insulin and‐like growth factor (IGF‐I)on oligodendrocyte‐enriched glial culture

1988 • 59 citations

Development of cholinergic pedunculopontine neurons in vitro: Comparison with Cholinergic septal cells and response to nerve growth factor, ciliary neuronotrophic factor, and retinoic acid

1988 • 57 citations

Effect of thyroid hormone analogs on the activity of choline acetyltransferase in cultures of dissociated septal cells

1986 • 56 citations

Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System

1987 • 55 citations

Purification of a human red blood cell protein supporting the survival of cultured CNS neurons, and its identification as catalase

1986 • 55 citations

Insulin inhibits specific norepinephrine uptake in neuronal cultures from rat brain

1986 • 55 citations

Ciliary Neuronotrophic Factor Stimulates Choline Acetyltransferase Activity in Cultured Chicken Retina Neurons

1988 • 54 citations

Insulin receptors in the peripheral nervous system: a structural and functional analysis

1987 • 52 citations

Purification of a Ciliary Neurotrophic Factor from Bovine Heart

1987 • 50 citations

Retrograde Axonal Transport

1983 • 50 citations

Epidermal Growth Factor in Synaptosomal Fractions of Mouse Cerebral Cortex

1986 • 49 citations

Development of cholinergic retinal neurons from embryonic chicken in monolayer cultures: stimulation by glial cell-derived factors

1988 • 49 citations

Insulin dependent neurite outgrowth in cultured embryonic mouse brain cells

1983 • 48 citations

Internalization and cycling of nerve growth factor in PC12 cells: Interconversion of type II (fast) and type I (slow) nerve growth factor receptors

1988 • 47 citations

Adult-level insulin binding is present in term fetal rat CNS membranes

1982 • 45 citations

Fibroblast growth factors: Potential neurotrophic agents in the central nervous system

1987 • 45 citations

Characterization of tissue-derived macromolecules affecting transmitter synthesis in rat spinal cord neurons

1985 • 41 citations

Identification of insulin receptor-containing cells in primary cultures of rat brain

1982 • 41 citations

Epidermal growth factor is not detectable in developing and adult rodent brain by a sensitive double-site enzyme immunoassay

1986 • 40 citations

Nerve growth factor (NGF) is present in human placenta and semen, but undetectable in normal and Paget's disease blood: measurements with an anti-mouse-NGF enzyme immunoassay using a recombinant human NGF reference

1988 • 40 citations

Insulin-like immunoreactivity in the human brain

1982 • 40 citations

Retinoic acid increases the expression of NGF gene in mouse L cells

1987 • 39 citations

Comparative features of spinal neuronotrophic factors in fluids collected in vitro and in vivo

1982 • 39 citations

An examination of ciliary neuronotrophic factors from avian and rodent tissue extracts using a blot and culture technique

1987 • 38 citations

Characterization of an inhibitor of neuronal plasminogen activator released by heart cells

1987 • 38 citations

Insulin promotes electrical coupling between cultured sympathetic neurons

1985 • 37 citations

Presence of basic fibroblast growth factor receptors in bovine brain membranes.

1988 • 37 citations

Properties of receptors for nerve growth factor in the mature rat nervous system

1987 • 36 citations

An effect of nerve growth factor on the parasympathetic ciliary ganglion

1984 • 35 citations

High molecular weight immunoreactive basic fibroblast growth factor-like proteins in rat pituitary and brain

1988 • 33 citations

Nerve Growth Factor

1985 • 32 citations

Distribution of fibroblast growth factor in the central and peripheral nervous systems of various mammals

1986 • 31 citations

Release of dopamine from coaggregate cultures of mesencephalic tegmentum and corpus striatum

1983 • 30 citations

Continous intracerebroventricular infusion of dopamine and dopamine agonists through a totally implanted drug delivery system in animal models of Parkinson's disease

1987 • 29 citations

Insulin-like growth factor II in the rat choroid plexus

1988 • 29 citations

Retrograde transport of NGF by early chick embryo spinal cord motoneurons

1988 • 28 citations

Thyroid Function in the Elderly

1982 • 28 citations

Subcellular Localization of Rat Brain Insulin Binding Sites

1988 • 27 citations

Presence of immunoreactive insulin in neurons cultured from fetal rat brain

1983 • 27 citations

Dose- and time-dependent hippocampal cholinergic lesions induced by ethylcholine mustard aziridinium ion: Effects of nerve growth factor, GM1 ganglioside, and vitamin E

1988 • 25 citations

Differential Effects of Nerve Growth Factor and Ciliary Neuronotrophic Factor on Catecholamine Storage and Catecholamine Synthesizing Enzymes of Cultured Rat Chromaffin Cells

1987 • 23 citations

Role of protease inhibition in cellular migration and neuritic growth

1987 • 22 citations

Influence of nerve growth factor on chick trigeminal motor nucleus explants

1987 • 22 citations

Neonatal treatment with nerve growth factor antiserum eliminates cholinergic sympathetic innervation of rat sweat glands

1985 • 22 citations

Synthesis of the trypsin fragment 10–25/75–88 of mouse nerve growth factor.

1987 • 21 citations

Intracerebroventricular cholinergic drug administration in Alzheimer's disease: preliminary results of a double-blind study.

1987 • 20 citations

Response of human glioblastoma cells to recombinant interleukin-2

1988 • 20 citations

The effects of neonatal thyroid deficiency on acetylcholine synthesis and glucose oxidation in rat corpus striatum

1985 • 19 citations

Effect of thyroidectomy on choline acetyltransferase in rat hypothalamic nuclei

1981 • 16 citations

Developmental discord among markers for cholinergic differentiation: In vitro time courses for early expression and responses to skeletal muscle extract

1988 • 14 citations

Synthesis of the trypsin fragment 10–25/75–88 of mouse nerve growth factor*

1987 • 12 citations

Neurochemical studies of early-onset Alzheimerʼs disease

1987 • 10 citations

Neural development and regeneration

1989 • 8 citations

Nerve Growth Factor Promotes Survival of Septal Cholinergic Neurons After Injury

1986 • 6 citations

Brain-derived neurotrophic factor

2021 • 6 citations

Cholinergic Neurons of the Rat Forebrain in Slice Cultures; Interactions with Target Tissue and Effects of Nerve Growth Factor

1988 • 4 citations

Trophic Effects of Striatal Proteins on Central Dopaminergic Neurons in Culture

1988 • 3 citations