Nerve Growth Factor Function in the Central Nervous System

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

A rapid radiochemical method for the determination of choline acetyltransferase

1975 • 2,406 citations

Nerve growth factor.

1968 • 2,025 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Regressive Events in Neurogenesis

1984 • 1,330 citations

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

1986 • 1,063 citations

Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities

1969 • 1,043 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death

1987 • 942 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

Hippocampal connections and spatial discrimination

1978 • 836 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

Local control of neurite development by nerve growth factor

1977 • 732 citations

NGF-Mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?

1983 • 725 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease

1981 • 698 citations

An analysis of the origins of the cholinergic and noncholinergic septal projections to the hippocampal formation of the rat

1985 • 676 citations

Trophic Interactions Between Astroglial Cells and Hippocampal Neurons in Culture

1980 • 672 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

Induction of nerve growth factor receptor in Schwann cells after axotomy.

1986 • 614 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat

1984 • 598 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding properties

1988 • 539 citations

Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons.

1986 • 528 citations

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.

1986 • 525 citations

Neuronal Chemotaxis: Chick Dorsal-Root Axons Turn Toward High Concentrations of Nerve Growth Factor

1979 • 522 citations

Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons

1985 • 491 citations

Characterization of the turning response of dorsal root neurites toward nerve growth factor.

1980 • 487 citations

Human β-nerve growth factor gene sequence highly homologous to that of mouse

1983 • 486 citations

Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor

1985 • 483 citations

Confirmation from choline acetylase analyses of a massive cholinergic innervation to the rat hippocampus

1967 • 469 citations

Evidence for a cholinergic projection to neocortex from neurons in basal forebrain.

1979 • 459 citations

In Vitro Experiments on the Effects of Mouse Sarcomas 180 and 37 on the Spinal and Sympathetic Ganglia of the Chick Embryo

1997 • 449 citations

Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions

1984 • 446 citations

Neocortical cholinergic innervation: A description of extrinsic and intrinsic components in the rat

1981 • 442 citations

Nerve Growth Factor Gene Expression in the Developing Rat Brain

1986 • 436 citations

Nerve growth factor (NGF) in the rat CNS: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra

1979 • 422 citations

Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro

1963 • 417 citations

Distribution of neuronal receptors for nerve growth factor in the rat

1986 • 398 citations

Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity

1983 • 389 citations

Naturally Occurring Neuronal Death in Vertebrates

1990 • 389 citations

Adult rat brain astrocytes support survival of both NGF-dependent and NGF-insensitive neurones

1979 • 378 citations

Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons

1986 • 377 citations

Degenerative Changes in Forebrain Cholinergic Nuclei Correlate with Cognitive Impairments in Aged Rats

1989 • 335 citations

Morphological response of axotomized septal neurons to nerve growth factor

1988 • 323 citations

Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes

1988 • 321 citations

Laminin is induced in astrocytes of adult brain by injury.

1984 • 315 citations

STUDIES OF THE CONNEXIONS OF THE FORNIX SYSTEM

1954 • 312 citations

Naturally Occurring Neuron Death and Its Regulation by Developing Neural Pathways

1982 • 306 citations

Metabolic Compartmentation and Neurotransmission

1975 • 301 citations

Cholinergic and non-cholinergic septohippocampal pathways

1985 • 297 citations

Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures

1982 • 291 citations

Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro

1988 • 286 citations

Chemotactic response of nerve fiber elongation to nerve growth factor

1978 • 279 citations

New Neuronal Growth Factors

1984 • 269 citations

Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: Response to fimbria‐fornix transection

1989 • 255 citations

An anatomical study of the development of the septo-hippocampal projection in the rat

1983 • 251 citations

Regeneration of the septohippocampal pathways in adult rats is promoted by utilizing embryonic hippocampal implants as bridges

1981 • 249 citations

Nerve growth factor promotes cholinergic development in brain striatal cultures.

1985 • 245 citations

NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum

1989 • 241 citations

Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain

1987 • 237 citations

Retrograde cell changes in medial septum and diagonal band following fimbria-fornix transection: Quantitative temporal analysis

1986 • 235 citations

Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage

1988 • 233 citations

Astrocytes are important for sprouting in the septohippocampal circuit

1988 • 230 citations

Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism

1986 • 224 citations

Role of nerve growth factor in the development of rat sympathetic neurons in vitro. I. Survival, growth, and differentiation of catecholamine production.

1977 • 218 citations

Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment

1988 • 213 citations

Molecular characteristics of nerve growth factor receptors on PC12 cells.

1985 • 200 citations

Neuronotrophic activity in brain wounds of the developing rat. Correlation with implant survival in the wound cavity

1983 • 197 citations

Proliferative and migratory activity of glial cells in the partially deafferented hippocampus

1979 • 197 citations

Retrograde changes in cholinergic neurons in the basal forebrain of the rat following cortical damage

1983 • 197 citations

Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.

1984 • 197 citations

Basal forebrain magnocellular neurons stain for nerve growth factor receptor: Correlation with cholinergic cell bodies and effects of axotomy

1987 • 193 citations

TOPOGRAPHICAL AND SUBCELLULAR LOCALIZATION OF CHOLINE ACETYLTRANSFERASE IN RAT HIPPOCAMPAL REGION

1970 • 191 citations

New Neurotrophic Factors

1983 • 190 citations

Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content

1986 • 188 citations

Anomalous innervation of the hippocampal formation by peripheral sympathetic axons following mechanical injury

1977 • 185 citations

An immunohistochemical study on the location of GABAergic neurons in rat septum

1984 • 180 citations

In Vitro Evidence for Two Distinct Hippocampal Growth Factors: Basis of Neuronal Plasticity?

1982 • 177 citations

Characterization of the binding properties and retrograde axonal transport of a monoclonal antibody directed against the rat nerve growth factor receptor.

1985 • 175 citations

Quantitative in vitro studies on the nerve growth factor (NGF) requirement of neurons

1977 • 173 citations

Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions

1985 • 172 citations

The localization and distribution of high affinity β-nerve growth factor binding sites in the central nervous system of the adult rat. A light microscopic autoradiographic study using [125I]β-nerve growth factor

1987 • 169 citations

Rat astrocytes and Schwann cells in culture synthesize nerve growth factor-like neurite-promoting factors

1987 • 165 citations

Astroglial cells provide a template for the positioning of developing cerebellar neurons in vitro.

1981 • 163 citations

The cholinergic nuclei of the basal forebrain of the rat: normal structure, development and experimentally induced degeneration

1987 • 161 citations

Enhanced graft survival in the hippocampus following selective denervation

1986 • 158 citations

Tissue explants affecting extension and orientation of axons in cultured chick embryo ganglia*1

1977 • 158 citations

Developmentally regulated expression of the nerve growth factor receptor gene in the periphery and brain.

1987 • 157 citations

Denervation releases a neuronal survival factor in adult rat hippocampus

1984 • 154 citations

Interactions between neurons and their targets during in vivo synaptogenesis.

1978 • 152 citations

The output of neuronotrophic and neurite-promoting agents from rat brain astroglial cells: a microculture method for screening potential regulatory molecules

1985 • 148 citations

Activity and the control of ganglion cell death in the rat retina.

1984 • 147 citations

Sympathetic sprouting in the central nervous system: a model for studies of axonal growth in the mature mammalian brain

1987 • 139 citations

Transient expression of NGF-receptor-like immunoreactivity in postnatal rat brain and spinal cord

1988 • 134 citations

Choline acetyltransferase and acetylcholinesterase in fascia dentata following lesion of the entorhinal afferents

1974 • 129 citations

Retrograde cell degeneration in the basal nucleus in monkey and man

1983 • 125 citations

Functional correlates of compensatory collateral sprouting by aminergic and cholinergic afferents in the hippocampal formation

1983 • 125 citations

beta-Nerve growth factor (beta NGF) receptors on glial cells. Cell-cell interaction between neurones and Schwann cells in cultures of chick sensory ganglia.

1983 • 125 citations

Selective growth of sympathetic nerve fibers to explants of normally densely innervated autonomic effector organs in tissue culture

1973 • 122 citations

NGF effects on developing forebrain cholinergic neurons are regionally specific

1987 • 120 citations

Neurotrophic activity in the adult rat hippocampal formation: regional distribution and increase after septal lesion

1985 • 118 citations

Selective induction of tyrosine hydroxylase and dopamine β-hydroxylase by nerve growth factor: comparison between adrenal medulla and sympathetic ganglia of adult and newborn rats

1977 • 113 citations

Nerve growth factor selectively increases cholinergic markers but not neuropeptides in rat basal forebrain in culture

1987 • 113 citations

Nerve growth factor infusions combined with fetal hippocampal grafts enhance reconstruction of the lesioned septohippocampal projection

1990 • 113 citations

Response of septal cholinergic neurons to axotomy

1987 • 108 citations

Differential effects of nerve-growth factor and glioma-conditioned medium on neurons cultured from various regions of fetal rat central nervous system

1986 • 94 citations

Sensory neurite growth cone guidance by substrate adsorbed nerve growth factor

1985 • 91 citations

Effect of Unilateral Decortication on Choline Acetyltransferase Activity in the Nucleus Basalis and Other Areas of the Rat Brain

1985 • 91 citations

Role of nerve growth factor in the development of rat sympathetic neurons in vitro. II. Developmental studies.

1977 • 88 citations

Presence and disappearance of nerve growth factor receptors on sensory neurons in culture

1982 • 87 citations

Differential effects of nerve-growth factor and glioma-conditioned medium on neurons cultured from various regions of fetal rat central nervous system

1986 • 85 citations

Loss of GABAergic neurons in medial septum after fimbria-fornix transection

1987 • 80 citations

Nerve growth factor promotes development of the rat septo-hippocampal cholinergic projection in vitro

1987 • 80 citations

Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor

1986 • 75 citations

An effect of nerve growth factor on parasympathetic neurite outgrowth.

1983 • 74 citations

Localization of nerve growth factor-like immunoreactivity in rat nervous tissue.

1983 • 73 citations

Role of nerve growth factor in the development of rat sympathetic neurons in vitro. III. Effect on acetylcholine production.

1977 • 73 citations

Enhanced afferent synaptic functions in fetal mouse spinal cord-sensory ganglion explants following NGF-induced ganglion hypertrophy

1974 • 73 citations

Autoimmunity and autoimmune disease

1988 • 69 citations

THE ROLE OF NERVE GROWTH FACTOR IN THE RAMIFICATION OF SYMPATHETIC NERVE FIBRES INTO THE RAT IRIS IN ORGAN CULTURE

1972 • 68 citations

Nonneuronal cells from chick sympathetic and dorsal root sensory ganglia express catecholamine uptake and receptors for nerve growth factor during development

1985 • 67 citations

Nerve growth factor receptors

1997 • 66 citations

Simultaneous expression of neuronal and glial properties by chick ciliary ganglion cells during development

1983 • 64 citations

Cholinergic neurons within the rat hippocampus: Response to fimbria‐fornix transection

1988 • 63 citations

Release of nerve growth factor by human glial cells in culture

1980 • 62 citations

Failure of nerve growth factor to affect fetal mouse brain stem catecholaminergic neurons in culture

1980 • 62 citations

Induction of fibre outgrowth and choline acetyltransferase in PC12 pheochromocytoma cells by conditioned media from glial cells and organ extracts

1979 • 59 citations

ROLE OF NERVE GROWTH FACTOR IN THE DEVELOPMENT OF RAT SYMPATHETIC NEURONS IN VITRO

1977 • 57 citations

Receptor-Receptor Interactions

1987 • 53 citations

NGF and Anti-NGF: Evidence against Effects on Fiber Growth in Locus coeruleus from Cultures of Perinatal CNS Tissues

1979 • 51 citations

Neural Grafting in the Aged Rat Brain

1986 • 43 citations

Nerve growth factor-mediated induction of tyrosine hydroxylase in rat superior cervical ganglia in vitro.

1978 • 43 citations

Properties of receptors for nerve growth factor in the mature rat nervous system

1987 • 36 citations

NGF receptor increase in the olfactory bulb of the rat after early odor deprivation

1989 • 35 citations

Synthesis and Secretion of a Nerve Growth- Stimulating Factor by Neonatal Mouse Astrocyte Cells in Vitro

1986 • 35 citations

Human amnion membrane matrix as a substratum for axonal regeneration in the central nervous system

1988 • 33 citations

Lysosomal enzyme changes in young and aged control and entorhinal-lesioned rats

1983 • 29 citations

Cholinergic neurons of fetal rat telencephalon in aggregating cell culture respond to NGF as well as to protein kinase C-activating tumor promoters

1986 • 28 citations

Bioassay detection of mouse nerve growth factor (mNGF) in the brain of adult mice

1981 • 28 citations

DEGENERATION AND ORIENTED GROWTH OF AUTONOMIC NERVES IN RELATION TO SMOOTH MUSCLE IN JOINT TISSUE CULTURES AND ANTERIOR EYE CHAMBER TRANSPLANTS

1974 • 22 citations

THE DE NOVO SYNTHESIS OF TYROSINE HYDROXYLASE IN RAT SUPERIOR CERVICAL GANGLIA IN VITRO: THE EFFECT OF NERVE GROWTH FACTOR

1977 • 17 citations

Physiology of CNS Tissues in Culture

1975 • 8 citations

Receptor-Receptor Interactions

2013 • 5 citations

Cholinergic Neurons of the Rat Forebrain in Slice Cultures; Interactions with Target Tissue and Effects of Nerve Growth Factor

1988 • 4 citations