Voltage-sensitive Na+ channels: motifs, modes and modulation

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

1990 • 1,528 citations

Primary structure of the receptor for calcium channel blockers from skeletal muscle

1987 • 1,359 citations

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1984 • 1,339 citations

Structural parts involved in activation and inactivation of the sodium channel

1989 • 1,189 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

1989 • 922 citations

Existence of distinct sodium channel messenger RNAs in rat brain

1986 • 909 citations

Primary structure and functional expression from complementary DNA of a brain calcium channel

1991 • 871 citations

Mutations Affecting Internal TEA Blockade Identify the Probable Pore-Forming Region of a K ⁺ Channel

1991 • 634 citations

Mutations Affecting Tea Blockade and Ion Permeation in Voltage-activated K ⁺ Channels

1990 • 569 citations

Primary structure and functional expression of a mammalian skeletal muscle sodium channel

1989 • 561 citations

Sodium channels and gating currents.

1981 • 541 citations

Expression of functional sodium channels from cloned cDNA

1986 • 537 citations

Molecular model of the action potential sodium channel.

1986 • 525 citations

Molecular analysis of the para locus, a sodium channel gene in Drosophila

1989 • 501 citations

Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform.

1989 • 388 citations

Exchange of Conduction Pathways Between Two Related K ⁺ Channels

1991 • 387 citations

Identification of an Intracellular Peptide Segment Involved in Sodium Channel Inactivation

1988 • 382 citations

A rat brain na+ channel α subunit with novel gating properties

1988 • 359 citations

The sodium channel from rat brain. Purification and subunit composition.

1984 • 352 citations

Mutant Potassium Channels with Altered Binding of Charybdotoxin, a Pore-Blocking Peptide Inhibitor

1989 • 351 citations

A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II

1989 • 336 citations

Primary structure of rat brain sodium channel III deduced from the cDNA sequence

1988 • 334 citations

Pursuing the structure and function of voltage-gated channels

1990 • 323 citations

Hyperkalemic Periodic Paralysis and the Adult Muscle Sodium Channel α-Subunit Gene

1990 • 304 citations

Primary structure and expression of a sodium channel characteristic of denervated and immature rat skeletal muscle

1990 • 297 citations

The receptor for tetrodotoxin and saxitoxin. A structural hypothesis

1975 • 295 citations

Principal glycopeptide of the tetrodotoxin/saxitoxin binding protein from Electrophorus electricus: isolation and partial chemical and physical characterization

1983 • 264 citations

Genomic Organization and Deduced Amino Acid Sequence of a Putative Sodium Channel Gene in Drosophila

1987 • 244 citations

Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor

1990 • 220 citations

A sodium channel defect in hyperkalemic periodic paralysis: Potassium-induced failure of inactivation

1991 • 213 citations

A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel.

1990 • 186 citations

Two modes of gating during late Na+ channel currents in frog sartorius muscle.

1986 • 182 citations

Fast and slow steps in the activation of sodium channels.

1979 • 178 citations

The nonlinear pathway of Y ganglion cells in the cat retina.

1979 • 176 citations

The sodium channel from rat brain. Separation and characterization of subunits.

1985 • 176 citations

Fast and slow gating of sodium channels encoded by a single mRNA

1990 • 162 citations

Functional expression of cloned cDNA encoding sodium channel III

1988 • 160 citations

Multiple gating modes and the effect of modulating factors on the μI sodium channel

1991 • 158 citations

Multiple oligosaccharide chains in the voltage-sensitive Na channel from Electrophorus electricus: Evidence for α-2,8-linked polysialic acid

1987 • 111 citations

Identification of an intracellular domain of the sodium channel having multiple cAMP-dependent phosphorylation sites.

1987 • 106 citations

Two sodium-channel genes in Drosophila: implications for channel diversity.

1989 • 98 citations

Evidence for the involvement of more than one mRNA species in controlling the inactivation process of rat and rabbit brain Na channels expressed in Xenopus oocytes

1988 • 97 citations

Modal gating behavior of cardiac sodium channels in cell-free membrane patches

1988 • 96 citations

Molecular Diversity of Voltage-Sensitive Na Channels

1989 • 96 citations

Voltage-operated channels induced by foreign messenger RNA in Xenopus oocytes

1983 • 95 citations

Changes in Sodium Channel Gating Produced by Point Mutations in a Cytoplasmic Linker

1990 • 93 citations

Purification and functional reconstitution of the voltage-sensitive sodium channel from rabbit T-tubular membranes.

1985 • 88 citations

Batrachotoxin-modified sodium channels in planar lipid bilayers. Characterization of saxitoxin- and tetrodotoxin-induced channel closures.

1987 • 81 citations

Analysis in a large hyperkalemic periodic paralysis pedigree supports tight linkage to a sodium channel locus.

1991 • 69 citations

Interactions of Scorpion Toxins with the Sodium Channel

1986 • 69 citations

Functional expression of the rat heart I Na⁺ channel isoform Demonstration of properties characteristic of native cardiac Na⁺ channels

1990 • 68 citations

Phosphorylation of the α Subunit of Rat Brain Sodium Channels by cAMP-dependent Protein Kinase at a New Site Containing Ser686 and Ser687

1989 • 66 citations

Competitive binding interaction between Zn2+ and saxitoxin in cardiac Na+ channels. Evidence for a sulfhydryl group in the Zn2+/saxitoxin binding site

1991 • 60 citations

Immunoaffinity isolation of Na+ channels from rat skeletal muscle. Analysis of subunits.

1986 • 57 citations

High resolution ¹H NMR study of the solution structure of the S4 segment of the sodium channel protein

1989 • 45 citations

Identification of phosphorylation sites for adenosine 3',5'-cyclic phosphate dependent protein kinase on the voltage-sensitive sodium channel from Electrophorus electricus

1989 • 33 citations

Kinetic diversity of Na+ channel bursts in frog skeletal muscle.

1989 • 33 citations

Affinity purification of the voltage-sensitive sodium channel from electroplax with resins selective for sialic acid

1989 • 23 citations

Voltage activation of purified eel sodium channels reconstituted into artificial liposomes

1990 • 17 citations

α-(2 → 8)-Polysialic acid immunoreactivity in voltage-sensitive sodium channel of eel electric organ

1989 • 15 citations

Batrachotoxin‐Modified Sodium Channels in Lipid Bilayers^a

1984 • 15 citations

Chapter 17 Voltage-Sensitive Sodium Channels: Molecular Structure and Function

1988 • 6 citations

Chapter 12 Molecular Characteristics of Sodium Channels in Skeletal Muscle

1988 • 4 citations