T Cell Response in Experimental Autoimmune Encephalomyelitis (EAE): Role of Self and Cross-Reactive Antigens in Shaping, Tuning, and Regulating the Autopathogenic T Cell Repertoire

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Amino Acid Homology Between the Encephalitogenic Site of Myelin Basic Protein and Virus: Mechanism for Autoimmunity

1985 • 941 citations

A very high level of crossreactivity is an essential feature of the T-cell receptor

1998 • 930 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Negative selection of lymphocytes

1994 • 810 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

1998 • 669 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.

1994 • 599 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

Positive selection of lymphocytes

1994 • 563 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

IL-10 Is Critical in the Regulation of Autoimmune Encephalomyelitis as Demonstrated by Studies of IL-10- and IL-4-Deficient and Transgenic Mice

1998 • 558 citations

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

1997 • 558 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

1985 • 522 citations

Molecular Mimicry by Herpes Simplex Virus-Type 1: Autoimmune Disease After Viral Infection

1998 • 505 citations

An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease

1998 • 479 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1995 • 422 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

Cytokine regulation of T-cell function: potential for therapeutic intervention

1993 • 412 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

1984 • 340 citations

Essential flexibility in the T-cell recognition of antigen

1996 • 330 citations

Functional Responses and Costimulator Dependence of Memory CD4+ T Cells

2000 • 318 citations

Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice.

1992 • 299 citations

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity

1999 • 284 citations

High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice

2000 • 275 citations

Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells.

1982 • 261 citations

The fine specificity of antigen and la determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c

1982 • 244 citations

Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses.

1992 • 230 citations

Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis

1999 • 219 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire.

1994 • 216 citations

Lymphocyte Targeting of the Central Nervous System: A Review of Afferent and Efferent CNS‐Immune Pathways

1996 • 210 citations

Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous Ligands

1995 • 209 citations

Transgenic Interleukin 10 Prevents Induction of Experimental Autoimmune Encephalomyelitis

1999 • 203 citations

A virus-induced molecular mimicry model of multiple sclerosis

2001 • 197 citations

The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems.

1993 • 194 citations

Thymic expression of autoantigens correlates with resistance to autoimmune disease.

1997 • 193 citations

Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell Repertoire

1998 • 188 citations

Differential Tolerance Is Induced in T Cells Recognizing Distinct Epitopes of Myelin Basic Protein

1998 • 182 citations

IL-12 unmasks latent autoimmune disease in resistant mice.

1996 • 182 citations

Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells.

1995 • 178 citations

Transcription of a Broad Range of Self-Antigens in Human Thymus Suggests a Role for Central Mechanisms in Tolerance Toward Peripheral Antigens

1998 • 173 citations

A virus-induced molecular mimicry model of multiple sclerosis

2001 • 171 citations

Microbial products induce autoimmune disease by an IL-12-dependent pathway.

1997 • 170 citations

Negative Selection during the Peripheral Immune Response to Antigen

2000 • 165 citations

The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases

1994 • 165 citations

Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor

2000 • 158 citations

A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens

1997 • 158 citations

Intrathymic Expression of Genes Involved in Organ Specific Autoimmune Disease

1998 • 155 citations

Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage.

1992 • 135 citations

The Shaping of the T Cell Repertoire

2001 • 134 citations

Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis.

1991 • 130 citations

The Thymus Contains a High Frequency of Cells that Prevent Autoimmune Diabetes on Transfer into Prediabetic Recipients

1996 • 128 citations

Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells.

1995 • 127 citations

T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

1994 • 123 citations

T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.

1995 • 121 citations

Autoreactivity of T cells from nonobese diabetic mice: An I-A^g7-dependent reaction

1998 • 115 citations

Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice.

1996 • 115 citations

Age-Dependent T Cell Tolerance and Autoimmunity to Myelin Basic Protein

2001 • 109 citations

CD4⁺ suppressor cells of autoimmune encephalomyelitis respond to T cell receptor‐associated determinants on effector cells by interleukin‐4 secretion

1992 • 108 citations

A New Look at MHC and Autoimmune Disease

1999 • 105 citations

Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo.

1993 • 104 citations

Immunology of multiple sclerosis.

1994 • 100 citations

Traffic of Hematogenous Cells Through the Central Nervous System

1995 • 98 citations

Passive Transfer of Adjuvant-induced Arthritis and Allergic Encephalomyelitis in Rats using Thoracic Duct Lymphocytes

1969 • 96 citations

Breaking self-tolerance in nonobese diabetic mice.

1996 • 88 citations

Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7

1997 • 81 citations

Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: Implications for autoimmunity

1998 • 80 citations

pH-dependent Peptide Binding Properties of the Type I Diabetes–associated I-Ag7 Molecule: Rapid Release of CLIP at an Endosomal pH

1999 • 79 citations

Analysis of the Role of Variation of Major Histocompatibility Complex Class II Expression on Nonobese Diabetic (NOD) Peripheral T Cell Response

1998 • 76 citations

The genetics and epidemiology of diabetes in NOD mice

1990 • 71 citations

Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4⁺T cells

2000 • 68 citations

Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines

1999 • 67 citations

Autopathogenic T Helper Cell Type 1 (Th1) and Protective Th2 Clones Differ in Their Recognition of the Autoantigenic Peptide of Myelin Proteolipid Protein

1997 • 66 citations

The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. T cell receptors in inflammatory lesions.

1992 • 66 citations

Myelin protein expression in lymphoid tissues: implications for peripheral tolerance

1998 • 64 citations

Expression of Thyroid-Related Genes in Human Thymus

1999 • 62 citations

Thymic expression of myelin basic protein (MBP). Activation of MBP-specific T cells by thymic cells in the absence of exogenous MBP.

1996 • 59 citations

Microbial Epitopes Act as Altered Peptide Ligands to Prevent Experimental Autoimmune Encephalomyelitis

1999 • 59 citations

Expression of the myelin proteolipid protein gene in the human fetal thymus

1996 • 59 citations

Expansion by Self Antigen Is Necessary for the Induction of Experimental Autoimmune Encephalomyelitis by T Cells Primed with a Cross-Reactive Environmental Antigen

1998 • 56 citations

Formation of synaptic endings by colossal fibers in the vestibular epithelium of the chick embryo

1977 • 45 citations

Tuning T cell activation threshold and effector function with cross-reactive peptide ligands

2000 • 41 citations

Altered peptide ligand modulation of experimental allergic encephalomyelitis: immune responses within the CNS

1998 • 40 citations

T cell recognition of self and altered self antigens.

1997 • 32 citations

Expression of ocular autoantigens in the mouse thymus

1998 • 29 citations

The Inability of the Nonobese Diabetic Class II Molecule to Form Stable Peptide Complexes Does Not Reflect a Failure to Interact Productively with DM

1998 • 28 citations

Fine specificity of CD4+ T cell responses to the dominant encephalitogenic PLP 139-151 peptide in SJL/J mice

1994 • 23 citations

The T cell receptor as a diverse signal transduction machine.

1996 • 22 citations

Polarized patterns of cytokine secretion

1993 • 13 citations

Myelin Proteolipid Protein-Induced Th1 and Th2 Clones Express TCR with Similar Fine Specificity for Peptide and CDR3 Homology Despite Diverse Vβ Usage

1995 • 12 citations

Differential recognition of MBP epitopes in BALB/c mice determines the site of inflammatory disease induction

1998 • 9 citations