Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

FVB/N: an inbred mouse strain preferable for transgenic analyses.

1991 • 600 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.

1993 • 277 citations

High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice

2000 • 275 citations

The V-region disease hypothesis: evidence from autoimmune encephalomyelitis

1989 • 190 citations

Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell Repertoire

1998 • 188 citations

Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a nonfunctional α‐mRNA of BW5147 origin

1989 • 188 citations

Differential Tolerance Is Induced in T Cells Recognizing Distinct Epitopes of Myelin Basic Protein

1998 • 182 citations

Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice.

1988 • 172 citations

Cassette vectors directing expression of T cell receptor genes in transgenic mice

1995 • 159 citations

Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

1990 • 140 citations

Gender differences in autoimmune demyelination in the mouse: Implications for multiple sclerosis

1996 • 135 citations

Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage.

1992 • 135 citations

Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice.

1992 • 134 citations

Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein.

1996 • 134 citations

Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis.

1991 • 130 citations

A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.

1988 • 126 citations

Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice.

1996 • 115 citations

CD4 Augments the Response of a T Cell to Agonist but Not to Antagonist Ligands

1997 • 114 citations

Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo.

1993 • 104 citations

The major myelin protein genes are expressed in the human thymus

1996 • 100 citations

Identification of a major encephalitogenic epitope of proteolipid protein (residues 56-70) for the induction of experimental allergic encephalomyelitis in Biozzi AB/H and nonobese diabetic mice.

1993 • 80 citations

Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice.

1991 • 72 citations

The immunopathology of acute experimental allergic encephalomyelitis induced with myelin proteolipid protein. T cell receptors in inflammatory lesions.

1992 • 66 citations

Myelin protein expression in lymphoid tissues: implications for peripheral tolerance

1998 • 64 citations

T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice.

1994 • 32 citations