The Inability of the Nonobese Diabetic Class II Molecule to Form Stable Peptide Complexes Does Not Reflect a Failure to Interact Productively with DM

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Mediation by HLA-DM of dissociation of peptides from HLA-DR

1995 • 555 citations

The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

1986 • 424 citations

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

1987 • 402 citations

Acceleration of Diabetes in Young Nod Mice with a CD4 ⁺ Islet-specific T Cell Clone

1990 • 385 citations

An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules

1994 • 378 citations

Invariant Chain Structure and MHC Class II Function

1996 • 374 citations

Enhanced Dissociation of HLA-DR-Bound Peptides in the Presence of HLA-DM

1996 • 327 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Editing of the HLA-DR-peptide repertoire by HLA-DM.

1996 • 273 citations

HLA-DMA and DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1994 • 247 citations

Genetic control of autoimmunity in type 1 diabetes

1990 • 238 citations

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

1990 • 236 citations

The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.

1996 • 217 citations

Association Between HLA-DM and HLA-DR In Vivo

1996 • 149 citations

Analysis of the roles of CD4⁺ and CD8⁺ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice

1992 • 145 citations

Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody

1982 • 145 citations

Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells

1994 • 135 citations

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

1992 • 124 citations

Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs.

1996 • 121 citations

Autoimmune Diabetes in NOD Mouse Is L3T4 T-Lymphocyte Dependent

1987 • 115 citations

Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigen.

1994 • 113 citations

The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent.

1995 • 112 citations

Structural Intermediates in the Reactions of Antigenic Peptides with MHC Molecules

1989 • 107 citations

Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules.

1996 • 102 citations

Developing and shedding inhibitions: how MHC class II molecules reach maturity

1996 • 97 citations

The NOD mouse as a model of type I diabetes.

1987 • 96 citations

Self peptides isolated from MHC glycoproteins of non-obese diabetic mice.

1994 • 92 citations

A Peptide-binding Motif for I-Ag7, the Class II Major Histocompatibility Complex (MHC) Molecule of NOD and Biozzi AB/H Mice

1997 • 90 citations

Polymorphic Amino Acid Variations in HLA-DQ Are Associated With Systematic Physical Property Changes and Occurrence of IDDM

1995 • 89 citations

The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants.

1986 • 83 citations

Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7

1997 • 81 citations

Cross‐blocking studies with monoclonal antibodies against I‐A molecules of haplotypes b, d and k

1982 • 81 citations

Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM genes.

1994 • 78 citations

Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of IDDM. Members of the Swedish Childhood Diabetes Study

1995 • 75 citations

The genetics and epidemiology of diabetes in NOD mice

1990 • 71 citations

Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways.

1993 • 65 citations

Studies on Autoimmunity for T-Cell-Mediated β-Cell Destruction: Distinct Difference in β-Cell Destruction Between CD4+ and CD8+ T-Cell Clones Derived From Lymphocytes Infiltrating the Islets of NOD Mice

1992 • 60 citations

Epitope-specific enhancement of antigen presentation by invariant chain.

1993 • 52 citations

Autoimmune diabetes in NOD mouse is L3T4 T-lymphocyte dependent

1987 • 49 citations

Role of HLA Genes in Predisposition to Develop Insulin-dependent Diabetes Mellitus

1992 • 43 citations

DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules.

1996 • 42 citations

POPULATION ANALYSIS OF PROTECTION BY HLA‐DR AND DQ GENES FROM INSULIN‐DEPENDENT DIABETES MELLITUS IN SWEDISH CHILDREN WITH INSULIN‐DEPENDENT DIABETES AND CONTROLS

1995 • 41 citations

The function of invariant chain in class II-restricted antigen presentation

1995 • 33 citations

How HLA-DM Affects the Peptide Repertoire Bound to HLA-DR Molecules

1997 • 33 citations

Studies on autoimmunity for T-cell-mediated beta-cell destruction. Distinct difference in beta-cell destruction between CD4+ and CD8+ T-cell clones derived from lymphocytes infiltrating the islets of NOD mice

1992 • 27 citations

Mutations affecting antigen processing impair class II-restricted allorecognition.

1991 • 26 citations

Polymorphic structural features of modelled HLA-DQ molecules segregate according to susceptibility or resistance to IDDM

1995 • 25 citations

The Role of MHC Class II Genes in Susceptibility and Resistance to Type I Diabetes Mellitus in the NOD Mouse

1996 • 16 citations

An Ion Pair in Class II Major Histocompatibility Complex Heterodimers Critical for Surface Expression and Peptide Presentation

1995 • 15 citations

Distribution of HLA‐DQA1 and ‐DQB1 alleles and DQA1‐DQB1 genotypes among Senegalese patients with insulin‐dependent diabetes mellitus

1996 • 11 citations