The Thymus Contains a High Frequency of Cells that Prevent Autoimmune Diabetes on Transfer into Prediabetic Recipients

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

The route of re-circulation of lymphocytes in the rat

1964 • 1,449 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: Differentiation antigens of rat lymphocytes

1977 • 777 citations

Identification of Ia glycoproteins in rat thymus and purification from rat spleen

1979 • 682 citations

Two subsets of rat T lymphocytes defined with monoclonal antibodies

1980 • 678 citations

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1994 • 544 citations

Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells

1993 • 527 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

1990 • 399 citations

Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis.

1982 • 321 citations

Molecular and antigenic heterogeneity of the rat leukocyte‐common antigen from thymocytes and T and B lymphocytes

1985 • 286 citations

Tolerance of class I histocompatibility antigens expressed extrathymically

1989 • 251 citations

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

1995 • 248 citations

Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes

1994 • 246 citations

MRC OX-22, a monoclonal antibody that labels a new subset of T lymphocytes and reacts with the high molecular weight form of the leukocyte-common antigen.

1983 • 243 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

The binding of anti‐immunoglobulin antibodies to rat thymocytes and thoracic duct lymphocytes

1974 • 202 citations

Tolerance Induced by Thymic Epithelial Grafts in Birds

1987 • 167 citations

A Repopulation Assay For B and T Lymphocyte Stem Cells Employing Radiation Chimaeras

1981 • 158 citations

Spontaneous development of autoimmune thyroiditis in neonatally thymectomized mice.

1976 • 148 citations

Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice.

1993 • 136 citations

Autoimmune oophoritis in thymectomized mice: detection of circulating antibodies against oocytes.

1980 • 125 citations

Purification of human C3b inactivator by monoclonal-antibody affinity chromatography

1982 • 122 citations

The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: the Function of the Thymus in the Generation of the Regulatory T Cell Subset

1996 • 121 citations

Immunologic and clinical studies on murine experimental autoimmune gastritis induced by neonatal thymectomy

1988 • 113 citations

Evidence for a Thymus‐Dependent Form of Tolerance that is Not Based on Elimination or Anergy of Reactive T cells

1996 • 111 citations

Expression of soluble isoforms of rat CD45. Analysis by electron microscopy and use in epitope mapping of anti-CD45R monoclonal antibodies.

1992 • 87 citations

Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein

1995 • 74 citations

The Role of Thymic Epithelium in the Establishment of Transplantation Tolerance

1993 • 66 citations

Peripheral tolerance mechanisms prevent the development of autoreactive T cells in chimeras grafted with two minor incompatible thymuses

1989 • 44 citations

CD4⁺CD8⁻ thymocytes that express L‐selectin protect rats from diabetes upon adoptive transfer

1996 • 43 citations

Tolerance Induction as a Therapeutic Strategy for the Control of Autoimmune Endocrine Disease in Mouse Models

1995 • 30 citations

IDDM in Rats Induced by Thymectomy and Irradiation

1993 • 30 citations

Allelic exclusion of α chains in TCRs

1994 • 26 citations

The Role of Subsets of CD4 ⁺ T Cells in Autoimmunity

2007 • 21 citations

Acquisition of immunological self-recognition by the fetal rat.

1988 • 20 citations

Mice naturally tolerant to C5 have T cells that suppress the response to this antigen

1986 • 18 citations

The tolerization of rat thymocytes to xenogeneic erythrocytes: kinetics of induction and recovery

1981 • 11 citations

Cited By (0)

No citing papers found in database